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Title: Long non-coding RNA PCAT7 regulates ELF2 signaling through inhibition of miR-134-5p in nasopharyngeal carcinoma

Abstract

While some long noncoding RNAs (lncRNAs) might promote nasopharyngeal carcinoma (NPC) initiation and progression, the involved molecular mechanisms remain largely unclear. Here, we discovered the novel LncRNA, prostate cancer associated transcript 7 (PCAT7), which was overexpressed and associated with worse prognosis in NPC. Decreased PCAT7 expression was found to significantly suppress tumor cell proliferation in vitro, and inhibited tumor growth and reduced the expression of proliferation antigen Ki-67 in vivo. Rescue assay was performed to further confirm that PCAT7 contributed to the progression of NPC through regulating miR-134-5p/ELF2 signal pathway. These results indicated that PCAT7 might contribute to the tumor progression in NPC by functioning as a ceRNA to sponge miR-134-5p. - Highlights: • PCAT7 is up-regulated in human primary NPC tissues. • Expression of ELF2 is up-regulated in primary human NPC and negatively expressed related to miR-134-5p. • MiR-134-5p inhibits the tumorigenic potential of NPC cells by down-regulating oncogenic ELF2 gene. • PCAT7's oncogenic functions are partially through reverse regulation of miRNA-134-5p, and then activation of ELF2.

Authors:
; ; ; ;
Publication Date:
OSTI Identifier:
22719078
Resource Type:
Journal Article
Journal Name:
Biochemical and Biophysical Research Communications
Additional Journal Information:
Journal Volume: 491; Journal Issue: 2; Other Information: Copyright (c) 2017 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0006-291X
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; ANIMAL TISSUES; ANTIGENS; CARCINOMAS; CELL PROLIFERATION; IN VITRO; IN VIVO; INHIBITION; PROSTATE; RNA; TUMOR CELLS

Citation Formats

Liu, Yejun, Tao, Zezhang, Qu, Jining, Zhou, Xuhong, and Zhang, Chenghong. Long non-coding RNA PCAT7 regulates ELF2 signaling through inhibition of miR-134-5p in nasopharyngeal carcinoma. United States: N. p., 2017. Web. doi:10.1016/J.BBRC.2017.07.093.
Liu, Yejun, Tao, Zezhang, Qu, Jining, Zhou, Xuhong, & Zhang, Chenghong. Long non-coding RNA PCAT7 regulates ELF2 signaling through inhibition of miR-134-5p in nasopharyngeal carcinoma. United States. doi:10.1016/J.BBRC.2017.07.093.
Liu, Yejun, Tao, Zezhang, Qu, Jining, Zhou, Xuhong, and Zhang, Chenghong. Sat . "Long non-coding RNA PCAT7 regulates ELF2 signaling through inhibition of miR-134-5p in nasopharyngeal carcinoma". United States. doi:10.1016/J.BBRC.2017.07.093.
@article{osti_22719078,
title = {Long non-coding RNA PCAT7 regulates ELF2 signaling through inhibition of miR-134-5p in nasopharyngeal carcinoma},
author = {Liu, Yejun and Tao, Zezhang and Qu, Jining and Zhou, Xuhong and Zhang, Chenghong},
abstractNote = {While some long noncoding RNAs (lncRNAs) might promote nasopharyngeal carcinoma (NPC) initiation and progression, the involved molecular mechanisms remain largely unclear. Here, we discovered the novel LncRNA, prostate cancer associated transcript 7 (PCAT7), which was overexpressed and associated with worse prognosis in NPC. Decreased PCAT7 expression was found to significantly suppress tumor cell proliferation in vitro, and inhibited tumor growth and reduced the expression of proliferation antigen Ki-67 in vivo. Rescue assay was performed to further confirm that PCAT7 contributed to the progression of NPC through regulating miR-134-5p/ELF2 signal pathway. These results indicated that PCAT7 might contribute to the tumor progression in NPC by functioning as a ceRNA to sponge miR-134-5p. - Highlights: • PCAT7 is up-regulated in human primary NPC tissues. • Expression of ELF2 is up-regulated in primary human NPC and negatively expressed related to miR-134-5p. • MiR-134-5p inhibits the tumorigenic potential of NPC cells by down-regulating oncogenic ELF2 gene. • PCAT7's oncogenic functions are partially through reverse regulation of miRNA-134-5p, and then activation of ELF2.},
doi = {10.1016/J.BBRC.2017.07.093},
journal = {Biochemical and Biophysical Research Communications},
issn = {0006-291X},
number = 2,
volume = 491,
place = {United States},
year = {2017},
month = {9}
}