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Title: MREG suppresses thyroid cancer cell invasion and proliferation by inhibiting Akt-mTOR signaling

Abstract

Thyroid cancer has long been considered to arise in middle age and progress to more aggressive and lethal cancers after its repeated proliferation. In this research, we aimed at investigating the biological function and the underlying molecular mechanism of Melanoregulin (MREG) in thyroid cancer. It was found that the expression of MREG was significantly downregulated in thyroid cancer tissues. The downregulation of MREG expression was caused by epigenetic methylation. MREG overexpression could suppress the invasion and proliferation of thyroid cancer cells. While MREG knockdown promoted the invasion and proliferation of thyroid cancer cells. Furthermore, the phosphorylation of Akt or mTOR was decreased by MREG overexpression and increased by MREG knockdown. Moreover, Dactolisib (the inhibitor of mTOR) could abrogate silenced MREG induced thyroid cancer cell invasion and proliferation. Taken together, MREG regulates thyroid cancer cell invasion and proliferation through PI3K/Akt-mTOR signaling pathway. MREG may serve as a promising therapeutic strategy for thyroid cancer.

Authors:
 [1];  [2];  [3]; ;  [4];  [5];  [4];  [1]
  1. Department of Endocrinology, Jinan Central Hospital Affiliated to Shandong University, Jinan, Shandong 250013 (China)
  2. (China)
  3. Department of Thoracic Surgery, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, Shandong 264000 (China)
  4. Department of Endocrinology, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, Shandong 264000 (China)
  5. Department of Gynecology, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, Shandong 264000 (China)
Publication Date:
OSTI Identifier:
22719066
Resource Type:
Journal Article
Journal Name:
Biochemical and Biophysical Research Communications
Additional Journal Information:
Journal Volume: 491; Journal Issue: 1; Other Information: Copyright (c) 2017 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0006-291X
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; ANIMAL TISSUES; BIOLOGICAL FUNCTIONS; CELL PROLIFERATION; METHYLATION; NEOPLASMS; PHOSPHORYLATION; THYROID

Citation Formats

Meng, Xiaomei, Department of Endocrinology, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, Shandong 264000, Dong, Yaozhong, Yu, Xiao, Wang, Daping, Wang, Shaoguang, Chen, Shulin, and Pang, Shuguang. MREG suppresses thyroid cancer cell invasion and proliferation by inhibiting Akt-mTOR signaling. United States: N. p., 2017. Web. doi:10.1016/J.BBRC.2017.07.044.
Meng, Xiaomei, Department of Endocrinology, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, Shandong 264000, Dong, Yaozhong, Yu, Xiao, Wang, Daping, Wang, Shaoguang, Chen, Shulin, & Pang, Shuguang. MREG suppresses thyroid cancer cell invasion and proliferation by inhibiting Akt-mTOR signaling. United States. doi:10.1016/J.BBRC.2017.07.044.
Meng, Xiaomei, Department of Endocrinology, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, Shandong 264000, Dong, Yaozhong, Yu, Xiao, Wang, Daping, Wang, Shaoguang, Chen, Shulin, and Pang, Shuguang. Sat . "MREG suppresses thyroid cancer cell invasion and proliferation by inhibiting Akt-mTOR signaling". United States. doi:10.1016/J.BBRC.2017.07.044.
@article{osti_22719066,
title = {MREG suppresses thyroid cancer cell invasion and proliferation by inhibiting Akt-mTOR signaling},
author = {Meng, Xiaomei and Department of Endocrinology, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, Shandong 264000 and Dong, Yaozhong and Yu, Xiao and Wang, Daping and Wang, Shaoguang and Chen, Shulin and Pang, Shuguang},
abstractNote = {Thyroid cancer has long been considered to arise in middle age and progress to more aggressive and lethal cancers after its repeated proliferation. In this research, we aimed at investigating the biological function and the underlying molecular mechanism of Melanoregulin (MREG) in thyroid cancer. It was found that the expression of MREG was significantly downregulated in thyroid cancer tissues. The downregulation of MREG expression was caused by epigenetic methylation. MREG overexpression could suppress the invasion and proliferation of thyroid cancer cells. While MREG knockdown promoted the invasion and proliferation of thyroid cancer cells. Furthermore, the phosphorylation of Akt or mTOR was decreased by MREG overexpression and increased by MREG knockdown. Moreover, Dactolisib (the inhibitor of mTOR) could abrogate silenced MREG induced thyroid cancer cell invasion and proliferation. Taken together, MREG regulates thyroid cancer cell invasion and proliferation through PI3K/Akt-mTOR signaling pathway. MREG may serve as a promising therapeutic strategy for thyroid cancer.},
doi = {10.1016/J.BBRC.2017.07.044},
journal = {Biochemical and Biophysical Research Communications},
issn = {0006-291X},
number = 1,
volume = 491,
place = {United States},
year = {2017},
month = {9}
}