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Title: LIGHT is increased in patients with coronary disease and regulates inflammatory response and lipid metabolism in oxLDL-induced THP-1 macrophages

Abstract

Inflammation is critical for the progression of hyperlipidemia. Although the exact mechanism through which inflammation affects hyperlipidemia is not very clear, evidence suggests that the tumor necrosis factor superfamily member 14 (TNFSF14/LIGHT)LIGHT might regulate lipid metabolism. In this study we investigated the expression of LIGHT in patients with different stages of coronary disease. The expression of lipid metabolism-related enzymes and inflammation-related proteins were further explored in oxidized low-density lipoproteins (oxLDL)-induced THP-1 macrophages. We found that LIGHT is highly expressed and companied with severe inflammations in patients with coronary disease. LIGHT significantly enhanced inflammation response in oxLDL-induced THP-1 macrophages. We further demonstrated that LIGHT markedly decreased the levels of lipolytic genes and increased the expressions of lipogenic genes in oxLDL-induced THP-1 macrophages. In addition, our results showed that LIGHT exerts its pro-inflammatory and pro-lipogenesis roles through activating nuclear factor-kappa B (NF-κB) signaling pathway. Taken together our study has demonstrated that LIGHT NF-κB-dependently exacerbates inflammation response and promotes lipid accumulation, and provided a new potential target for treatment of hyperlipidemia-related disease. - Highlights: • Patients with atherosclerosis display high levels of LIGHT expression. • LIGHT promotes inflammation and lipid accumulation in THP-1 macrophages. • LIGHT regulates lipid metabolism via NF-κB signaling.

Authors:
 [1];  [2];  [3];  [4]
  1. Heart Failure Center, Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital, Chengdu, 610072 (China)
  2. Department of Cardiology, Guang'an People's Hospital, Guang'an, 638099 (China)
  3. Department of Cardiology, Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital, Chengdu, 610072 (China)
  4. Department of Geriatric Medicine, Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital, Chengdu, 610072 (China)
Publication Date:
OSTI Identifier:
22719048
Resource Type:
Journal Article
Journal Name:
Biochemical and Biophysical Research Communications
Additional Journal Information:
Journal Volume: 490; Journal Issue: 3; Other Information: Copyright (c) 2017 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0006-291X
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; ARTERIOSCLEROSIS; CARNITINE; CHOLESTEROL; CORONARIES; IMMUNOGLOBULINS; INFLAMMATION; LIGASES; LIPOPROTEINS; LYMPHOKINES; MACROPHAGES; METABOLISM; NECROSIS; NEOPLASMS; NITRIC OXIDE; PATIENTS; RECEPTORS

Citation Formats

Yuan, Xiaomei, Gu, Yonglin, Lai, Xiaoyu, and Gu, Qing. LIGHT is increased in patients with coronary disease and regulates inflammatory response and lipid metabolism in oxLDL-induced THP-1 macrophages. United States: N. p., 2017. Web. doi:10.1016/J.BBRC.2017.06.110.
Yuan, Xiaomei, Gu, Yonglin, Lai, Xiaoyu, & Gu, Qing. LIGHT is increased in patients with coronary disease and regulates inflammatory response and lipid metabolism in oxLDL-induced THP-1 macrophages. United States. doi:10.1016/J.BBRC.2017.06.110.
Yuan, Xiaomei, Gu, Yonglin, Lai, Xiaoyu, and Gu, Qing. Sat . "LIGHT is increased in patients with coronary disease and regulates inflammatory response and lipid metabolism in oxLDL-induced THP-1 macrophages". United States. doi:10.1016/J.BBRC.2017.06.110.
@article{osti_22719048,
title = {LIGHT is increased in patients with coronary disease and regulates inflammatory response and lipid metabolism in oxLDL-induced THP-1 macrophages},
author = {Yuan, Xiaomei and Gu, Yonglin and Lai, Xiaoyu and Gu, Qing},
abstractNote = {Inflammation is critical for the progression of hyperlipidemia. Although the exact mechanism through which inflammation affects hyperlipidemia is not very clear, evidence suggests that the tumor necrosis factor superfamily member 14 (TNFSF14/LIGHT)LIGHT might regulate lipid metabolism. In this study we investigated the expression of LIGHT in patients with different stages of coronary disease. The expression of lipid metabolism-related enzymes and inflammation-related proteins were further explored in oxidized low-density lipoproteins (oxLDL)-induced THP-1 macrophages. We found that LIGHT is highly expressed and companied with severe inflammations in patients with coronary disease. LIGHT significantly enhanced inflammation response in oxLDL-induced THP-1 macrophages. We further demonstrated that LIGHT markedly decreased the levels of lipolytic genes and increased the expressions of lipogenic genes in oxLDL-induced THP-1 macrophages. In addition, our results showed that LIGHT exerts its pro-inflammatory and pro-lipogenesis roles through activating nuclear factor-kappa B (NF-κB) signaling pathway. Taken together our study has demonstrated that LIGHT NF-κB-dependently exacerbates inflammation response and promotes lipid accumulation, and provided a new potential target for treatment of hyperlipidemia-related disease. - Highlights: • Patients with atherosclerosis display high levels of LIGHT expression. • LIGHT promotes inflammation and lipid accumulation in THP-1 macrophages. • LIGHT regulates lipid metabolism via NF-κB signaling.},
doi = {10.1016/J.BBRC.2017.06.110},
journal = {Biochemical and Biophysical Research Communications},
issn = {0006-291X},
number = 3,
volume = 490,
place = {United States},
year = {2017},
month = {8}
}