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Title: Astrocytes regulate the expression of Sp1R3 on oligodendrocyte progenitor cells through Cx47 and promote their proliferation

Abstract

Many degenerative diseases of the central nervous system are associated with demyelination. Oligodendrocyte progenitor cells (OPCs) are potential stem cells that can differentiate into various cell types, including oligodendrocytes (OLs). Promoting the proliferation and differentiation of OPCs into mature OLs that can myelinate axons is the key to stimulate remyelination. Here, we report that astrocytes (ASTs) increase the number of sphingosine-1-phosphate receptors 3 (S1pR3) on OPCs and promote OPCs proliferation through a direct contact via connexin 47 (Cx47). Our results demonstrate that ASTs can regulate the proliferation of OPCs through Cx47-mediated induction of S1pR3 expression on OPCs. Cx47/S1pR3 remarkably increases the number of OPCs and promotes cell transition from the G1 to the S phase. Furthermore, inhibiting either Cx47 or S1pR3 decreases OPC proliferation. In summary, ASTs regulate the expression of S1pR3 in OPCs via Cx47, which could be a valuable approach for promoting OPC proliferation. This strategy may therefore represent a potential treatment for neurological diseases caused by OLs death and demyelination. - Highlights: • Astrocytes through direct contact (connexin 47), can increase the number of OPCs surface proliferation receptors (S1pR3). • The increased number of OPCs on surface of proliferation receptors (S1pR3), promoted proliferation of OPCs. • Blockingmore » S1pR3 could decrease the proliferation of OPCs.« less

Authors:
 [1]; ; ;  [2];  [1]
  1. Department of Neurosurgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016 (China)
  2. Laboratory of Stem Cell and Tissue Engineering, Department of Histology and Embryology, Chongqing Medical University, Chongqing, 400016 (China)
Publication Date:
OSTI Identifier:
22719046
Resource Type:
Journal Article
Journal Name:
Biochemical and Biophysical Research Communications
Additional Journal Information:
Journal Volume: 490; Journal Issue: 3; Other Information: Copyright (c) 2017 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0006-291X
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; CENTRAL NERVOUS SYSTEM; DISEASES; NERVE CELLS; PHOSPHATES; RECEPTORS; STEM CELLS

Citation Formats

Xu, Dan, Liu, Zhaoyu, Wang, Shang, Peng, Yan, and Sun, Xiaochuan. Astrocytes regulate the expression of Sp1R3 on oligodendrocyte progenitor cells through Cx47 and promote their proliferation. United States: N. p., 2017. Web. doi:10.1016/J.BBRC.2017.06.099.
Xu, Dan, Liu, Zhaoyu, Wang, Shang, Peng, Yan, & Sun, Xiaochuan. Astrocytes regulate the expression of Sp1R3 on oligodendrocyte progenitor cells through Cx47 and promote their proliferation. United States. doi:10.1016/J.BBRC.2017.06.099.
Xu, Dan, Liu, Zhaoyu, Wang, Shang, Peng, Yan, and Sun, Xiaochuan. Sat . "Astrocytes regulate the expression of Sp1R3 on oligodendrocyte progenitor cells through Cx47 and promote their proliferation". United States. doi:10.1016/J.BBRC.2017.06.099.
@article{osti_22719046,
title = {Astrocytes regulate the expression of Sp1R3 on oligodendrocyte progenitor cells through Cx47 and promote their proliferation},
author = {Xu, Dan and Liu, Zhaoyu and Wang, Shang and Peng, Yan and Sun, Xiaochuan},
abstractNote = {Many degenerative diseases of the central nervous system are associated with demyelination. Oligodendrocyte progenitor cells (OPCs) are potential stem cells that can differentiate into various cell types, including oligodendrocytes (OLs). Promoting the proliferation and differentiation of OPCs into mature OLs that can myelinate axons is the key to stimulate remyelination. Here, we report that astrocytes (ASTs) increase the number of sphingosine-1-phosphate receptors 3 (S1pR3) on OPCs and promote OPCs proliferation through a direct contact via connexin 47 (Cx47). Our results demonstrate that ASTs can regulate the proliferation of OPCs through Cx47-mediated induction of S1pR3 expression on OPCs. Cx47/S1pR3 remarkably increases the number of OPCs and promotes cell transition from the G1 to the S phase. Furthermore, inhibiting either Cx47 or S1pR3 decreases OPC proliferation. In summary, ASTs regulate the expression of S1pR3 in OPCs via Cx47, which could be a valuable approach for promoting OPC proliferation. This strategy may therefore represent a potential treatment for neurological diseases caused by OLs death and demyelination. - Highlights: • Astrocytes through direct contact (connexin 47), can increase the number of OPCs surface proliferation receptors (S1pR3). • The increased number of OPCs on surface of proliferation receptors (S1pR3), promoted proliferation of OPCs. • Blocking S1pR3 could decrease the proliferation of OPCs.},
doi = {10.1016/J.BBRC.2017.06.099},
journal = {Biochemical and Biophysical Research Communications},
issn = {0006-291X},
number = 3,
volume = 490,
place = {United States},
year = {2017},
month = {8}
}