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Title: Per- and polyfluoroalkyl substances (PFAS) in American Red Cross adult blood donors, 2000–2015

Abstract

In 2015, thirteen per- and polyfluoroalkyl substances (PFAS), including perfluorohexanesulfonate (PFHxS), perfluorooctanesulfonate (PFOS), perfluorooctanoate (PFOA), perfluorononanoate (PFNA), and perfluorodecanoate (PFDA) were analyzed in human plasma that were collected from a total of 616 American Red Cross male and female blood donors (ages 20–69) at 6 regional blood collection centers. Plasma samples were analyzed using a validated solvent precipitation-isotope dilution direction-liquid chromatography tandem mass spectrometry method. The data were analyzed in conjunction with prior cross-sectional investigations [2000–2001 (n =645), 2006 (n =600), and 2010 (n =600)] to determine PFAS trends. Age- and sex-adjusted geometric mean serum (2000–2001) and plasma (2006, 2010, 2015) concentrations (ng/mL) were, respectively: PFHxS (2.3, 1.5, 1.3, 0.9); PFOS (35.1, 14.5, 8.4, 4.3); PFOA (4.7, 3.4, 2.4, 1.1); PFNA (0.6, 1.0, 0.8, 0.4); and PFDA (0.2, 0.3, 0.3, 0.1). The percentage decline in these geometric mean concentrations from 2000–2001 to 2015 were: PFHxS (61%); PFOS (88%); PFOA (77%); PFNA (33%); and PFDA (50%). The results indicate a continued decline of PFHxS, PFOS, and PFOA concentrations in American Red Cross blood donors. For the remaining PFAS measured in 2015, including the shorter chain perfluoroalkyls perfluorobutanesulfonate (PFBS) and perfluorohexanoate (PFHxA), the majority of samples were below the lower limit ofmore » quantitation. - Highlights: • In 2015, plasma from 616 American Red Cross adult blood donors measured for PFAS. • Prior collections of other donor samples were measured in 2000–2001, 2006, and 2010. • Percentage declines 2000–2001 to 2015 were 61% (PFHxS), 88% (PFOS), and 77% (PFOA). • In 2015 shorter chain perfluoroalkyls PFBS and PFHxA remained primarily < LLOQ.« less

Authors:
 [1];  [2]; ;  [3];  [4];  [5];  [6];  [7];  [8];  [9];  [3];  [1]
  1. 3M Company, Medical Department, St. Paul, MN (United States)
  2. American Red Cross, North Central Region, St. Paul, MN (United States)
  3. 3M Company, Environmental Laboratory, St. Paul, MN (United States)
  4. University of Minnesota, Division of Environmental Health Sciences, Minneapolis, MN (United States)
  5. American Red Cross, Carolinas Region, Charlotte, NC (United States)
  6. American Red Cross, Southern California Region, Los Angeles, CA (United States)
  7. American Red Cross, Pacific Northwest Region, Portland, OR (United States)
  8. American Red Cross, Greater Alleghenies Region, Johnstown, PA (United States)
  9. American Red Cross, New England Region, Dedham, MA (United States)
Publication Date:
OSTI Identifier:
22708023
Resource Type:
Journal Article
Journal Name:
Environmental Research
Additional Journal Information:
Journal Volume: 157; Other Information: Copyright (c) 2017 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0013-9351
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; 54 ENVIRONMENTAL SCIENCES; ADULTS; BLOOD; FLUORINE COMPOUNDS; MASS SPECTROSCOPY; PLASMA; SAMPLING; SULFONATES

Citation Formats

Olsen, Geary W., E-mail: gwolsen@mmm.com, Mair, David C., Lange, Cleston C., Harrington, Laura M., Church, Timothy R., Goldberg, Corinne L., Herron, Ross M., Hanna, Hank, Nobiletti, John B., Rios, Jorge A., Reagen, William K., and Ley, Carol A. Per- and polyfluoroalkyl substances (PFAS) in American Red Cross adult blood donors, 2000–2015. United States: N. p., 2017. Web. doi:10.1016/J.ENVRES.2017.05.013.
Olsen, Geary W., E-mail: gwolsen@mmm.com, Mair, David C., Lange, Cleston C., Harrington, Laura M., Church, Timothy R., Goldberg, Corinne L., Herron, Ross M., Hanna, Hank, Nobiletti, John B., Rios, Jorge A., Reagen, William K., & Ley, Carol A. Per- and polyfluoroalkyl substances (PFAS) in American Red Cross adult blood donors, 2000–2015. United States. doi:10.1016/J.ENVRES.2017.05.013.
Olsen, Geary W., E-mail: gwolsen@mmm.com, Mair, David C., Lange, Cleston C., Harrington, Laura M., Church, Timothy R., Goldberg, Corinne L., Herron, Ross M., Hanna, Hank, Nobiletti, John B., Rios, Jorge A., Reagen, William K., and Ley, Carol A. Tue . "Per- and polyfluoroalkyl substances (PFAS) in American Red Cross adult blood donors, 2000–2015". United States. doi:10.1016/J.ENVRES.2017.05.013.
@article{osti_22708023,
title = {Per- and polyfluoroalkyl substances (PFAS) in American Red Cross adult blood donors, 2000–2015},
author = {Olsen, Geary W., E-mail: gwolsen@mmm.com and Mair, David C. and Lange, Cleston C. and Harrington, Laura M. and Church, Timothy R. and Goldberg, Corinne L. and Herron, Ross M. and Hanna, Hank and Nobiletti, John B. and Rios, Jorge A. and Reagen, William K. and Ley, Carol A.},
abstractNote = {In 2015, thirteen per- and polyfluoroalkyl substances (PFAS), including perfluorohexanesulfonate (PFHxS), perfluorooctanesulfonate (PFOS), perfluorooctanoate (PFOA), perfluorononanoate (PFNA), and perfluorodecanoate (PFDA) were analyzed in human plasma that were collected from a total of 616 American Red Cross male and female blood donors (ages 20–69) at 6 regional blood collection centers. Plasma samples were analyzed using a validated solvent precipitation-isotope dilution direction-liquid chromatography tandem mass spectrometry method. The data were analyzed in conjunction with prior cross-sectional investigations [2000–2001 (n =645), 2006 (n =600), and 2010 (n =600)] to determine PFAS trends. Age- and sex-adjusted geometric mean serum (2000–2001) and plasma (2006, 2010, 2015) concentrations (ng/mL) were, respectively: PFHxS (2.3, 1.5, 1.3, 0.9); PFOS (35.1, 14.5, 8.4, 4.3); PFOA (4.7, 3.4, 2.4, 1.1); PFNA (0.6, 1.0, 0.8, 0.4); and PFDA (0.2, 0.3, 0.3, 0.1). The percentage decline in these geometric mean concentrations from 2000–2001 to 2015 were: PFHxS (61%); PFOS (88%); PFOA (77%); PFNA (33%); and PFDA (50%). The results indicate a continued decline of PFHxS, PFOS, and PFOA concentrations in American Red Cross blood donors. For the remaining PFAS measured in 2015, including the shorter chain perfluoroalkyls perfluorobutanesulfonate (PFBS) and perfluorohexanoate (PFHxA), the majority of samples were below the lower limit of quantitation. - Highlights: • In 2015, plasma from 616 American Red Cross adult blood donors measured for PFAS. • Prior collections of other donor samples were measured in 2000–2001, 2006, and 2010. • Percentage declines 2000–2001 to 2015 were 61% (PFHxS), 88% (PFOS), and 77% (PFOA). • In 2015 shorter chain perfluoroalkyls PFBS and PFHxA remained primarily < LLOQ.},
doi = {10.1016/J.ENVRES.2017.05.013},
journal = {Environmental Research},
issn = {0013-9351},
number = ,
volume = 157,
place = {United States},
year = {2017},
month = {8}
}