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Title: Cardiomyocyte-released factors stimulate oligodendrocyte precursor cells proliferation

Abstract

The heart produces multiple diffusible factors that are involved in a number of physiological processes, but the action of these factors on the central nervous system is not well understood. In this study, we found that one or more factors released by cardiomyocytes promote oligodendrocyte precursor cell (OPC) proliferation in vitro. Mouse OPCs co-cultured with mouse cardiomyocytes showed higher proliferative ability than OPCs cultured alone. In addition, cardiomyocyte-conditioned media was sufficient to promote OPC proliferation. The phosphorylation of phosphatidylinositol (PI) 3-kinase and extracellular signal-regulated kinase (ERK) in OPCs is necessary for the enhancement of OPC proliferation by cardiomyocyte-conditioned media. These data indicate that heart-derived factors have the ability to directly regulate the function of central nervous system (CNS) cells.

Authors:
 [1];  [1];  [2];  [1];  [3]
  1. Department of Molecular Neuroscience, Graduate School of Medicine, Osaka University, Suita, Osaka 565-0871 (Japan)
  2. (PRESTO), Japan Science and Technology Agency, 5, Sanbancho, Chiyoda-ku, Tokyo 102-0075 (Japan)
  3. (Japan)
Publication Date:
OSTI Identifier:
22696799
Resource Type:
Journal Article
Resource Relation:
Journal Name: Biochemical and Biophysical Research Communications; Journal Volume: 482; Journal Issue: 4; Other Information: Copyright (c) 2016 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; BRAIN; CELL PROLIFERATION; FUNCTIONS; HEART; IN VITRO; MICE; MYELIN; PHOSPHORYLATION; PHOSPHOTRANSFERASES; PRECURSOR; PROLIFERATION; SIGNALS

Citation Formats

Kuroda, Mariko, Muramatsu, Rieko, Precursory Research for Embryonic Science and Technology, Yamashita, Toshihide, and Graduate School of Frontier Biosciences, Osaka University, 1-3 Yamadaoka, Suita, Osaka 565-0871. Cardiomyocyte-released factors stimulate oligodendrocyte precursor cells proliferation. United States: N. p., 2017. Web. doi:10.1016/J.BBRC.2016.12.004.
Kuroda, Mariko, Muramatsu, Rieko, Precursory Research for Embryonic Science and Technology, Yamashita, Toshihide, & Graduate School of Frontier Biosciences, Osaka University, 1-3 Yamadaoka, Suita, Osaka 565-0871. Cardiomyocyte-released factors stimulate oligodendrocyte precursor cells proliferation. United States. doi:10.1016/J.BBRC.2016.12.004.
Kuroda, Mariko, Muramatsu, Rieko, Precursory Research for Embryonic Science and Technology, Yamashita, Toshihide, and Graduate School of Frontier Biosciences, Osaka University, 1-3 Yamadaoka, Suita, Osaka 565-0871. Sun . "Cardiomyocyte-released factors stimulate oligodendrocyte precursor cells proliferation". United States. doi:10.1016/J.BBRC.2016.12.004.
@article{osti_22696799,
title = {Cardiomyocyte-released factors stimulate oligodendrocyte precursor cells proliferation},
author = {Kuroda, Mariko and Muramatsu, Rieko and Precursory Research for Embryonic Science and Technology and Yamashita, Toshihide and Graduate School of Frontier Biosciences, Osaka University, 1-3 Yamadaoka, Suita, Osaka 565-0871},
abstractNote = {The heart produces multiple diffusible factors that are involved in a number of physiological processes, but the action of these factors on the central nervous system is not well understood. In this study, we found that one or more factors released by cardiomyocytes promote oligodendrocyte precursor cell (OPC) proliferation in vitro. Mouse OPCs co-cultured with mouse cardiomyocytes showed higher proliferative ability than OPCs cultured alone. In addition, cardiomyocyte-conditioned media was sufficient to promote OPC proliferation. The phosphorylation of phosphatidylinositol (PI) 3-kinase and extracellular signal-regulated kinase (ERK) in OPCs is necessary for the enhancement of OPC proliferation by cardiomyocyte-conditioned media. These data indicate that heart-derived factors have the ability to directly regulate the function of central nervous system (CNS) cells.},
doi = {10.1016/J.BBRC.2016.12.004},
journal = {Biochemical and Biophysical Research Communications},
number = 4,
volume = 482,
place = {United States},
year = {Sun Jan 22 00:00:00 EST 2017},
month = {Sun Jan 22 00:00:00 EST 2017}
}