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Title: Fibrosis biomarkers in workers exposed to MWCNTs

Abstract

Multi-walled carbon nanotubes (MWCNT) with their unique physico-chemical properties offer numerous technological advantages and are projected to drive the next generation of manufacturing growth. As MWCNT have already found utility in different industries including construction, engineering, energy production, space exploration and biomedicine, large quantities of MWCNT may reach the environment and inadvertently lead to human exposure. This necessitates the urgent assessment of their potential health effects in humans. The current study was carried out at NanotechCenter Ltd. Enterprise (Tambov, Russia) where large-scale manufacturing of MWCNT along with relatively high occupational exposure levels was reported. The goal of this small cross-sectional study was to evaluate potential biomarkers during occupational exposure to MWCNT. All air samples were collected at the workplaces from both specific areas and personal breathing zones using filter-based devices to quantitate elemental carbon and perform particle analysis by TEM. Biological fluids of nasal lavage, induced sputum and blood serum were obtained from MWCNT-exposed and non-exposed workers for assessment of inflammatory and fibrotic markers. It was found that exposure to MWCNTs caused significant increase in IL-1β, IL6, TNF-α, inflammatory cytokines and KL-6, a serological biomarker for interstitial lung disease in collected sputum samples. Moreover, the level of TGF-β1 was increasedmore » in serum obtained from young exposed workers. Overall, the results from this study revealed accumulation of inflammatory and fibrotic biomarkers in biofluids of workers manufacturing MWCNTs. Therefore, the biomarkers analyzed should be considered for the assessment of health effects of occupational exposure to MWCNT in cross-sectional epidemiological studies. - Highlights: • The effects of MWCNT exposure in humans remain unclear. • We found increased KL-6/TGF-β levels in the biofluids of MWCNT-exposed workers. • Inflammatory cytokines content was also increased in these workers. • The identified markers could be useful for potential health surveillance in exposed populations.« less

Authors:
Publication Date:
OSTI Identifier:
22689173
Resource Type:
Journal Article
Journal Name:
Toxicology and Applied Pharmacology
Additional Journal Information:
Journal Volume: 299; Other Information: Copyright (c) 2016 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0041-008X
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; BIOLOGICAL MARKERS; BLOOD SERUM; CARBON NANOTUBES; FIBROSIS; INFLAMMATION; LUNGS; LYMPHOKINES; OCCUPATIONAL EXPOSURE; PERSONNEL; TRANSMISSION ELECTRON MICROSCOPY

Citation Formats

Fatkhutdinova, Liliya M., E-mail: liliya.fatkhutdi. Fibrosis biomarkers in workers exposed to MWCNTs. United States: N. p., 2016. Web. doi:10.1016/J.TAAP.2016.02.016.
Fatkhutdinova, Liliya M., E-mail: liliya.fatkhutdi. Fibrosis biomarkers in workers exposed to MWCNTs. United States. doi:10.1016/J.TAAP.2016.02.016.
Fatkhutdinova, Liliya M., E-mail: liliya.fatkhutdi. Sun . "Fibrosis biomarkers in workers exposed to MWCNTs". United States. doi:10.1016/J.TAAP.2016.02.016.
@article{osti_22689173,
title = {Fibrosis biomarkers in workers exposed to MWCNTs},
author = {Fatkhutdinova, Liliya M., E-mail: liliya.fatkhutdi},
abstractNote = {Multi-walled carbon nanotubes (MWCNT) with their unique physico-chemical properties offer numerous technological advantages and are projected to drive the next generation of manufacturing growth. As MWCNT have already found utility in different industries including construction, engineering, energy production, space exploration and biomedicine, large quantities of MWCNT may reach the environment and inadvertently lead to human exposure. This necessitates the urgent assessment of their potential health effects in humans. The current study was carried out at NanotechCenter Ltd. Enterprise (Tambov, Russia) where large-scale manufacturing of MWCNT along with relatively high occupational exposure levels was reported. The goal of this small cross-sectional study was to evaluate potential biomarkers during occupational exposure to MWCNT. All air samples were collected at the workplaces from both specific areas and personal breathing zones using filter-based devices to quantitate elemental carbon and perform particle analysis by TEM. Biological fluids of nasal lavage, induced sputum and blood serum were obtained from MWCNT-exposed and non-exposed workers for assessment of inflammatory and fibrotic markers. It was found that exposure to MWCNTs caused significant increase in IL-1β, IL6, TNF-α, inflammatory cytokines and KL-6, a serological biomarker for interstitial lung disease in collected sputum samples. Moreover, the level of TGF-β1 was increased in serum obtained from young exposed workers. Overall, the results from this study revealed accumulation of inflammatory and fibrotic biomarkers in biofluids of workers manufacturing MWCNTs. Therefore, the biomarkers analyzed should be considered for the assessment of health effects of occupational exposure to MWCNT in cross-sectional epidemiological studies. - Highlights: • The effects of MWCNT exposure in humans remain unclear. • We found increased KL-6/TGF-β levels in the biofluids of MWCNT-exposed workers. • Inflammatory cytokines content was also increased in these workers. • The identified markers could be useful for potential health surveillance in exposed populations.},
doi = {10.1016/J.TAAP.2016.02.016},
journal = {Toxicology and Applied Pharmacology},
issn = {0041-008X},
number = ,
volume = 299,
place = {United States},
year = {2016},
month = {5}
}