Synthetic Biology Outside the Cell: Linking Computational Tools to Cell-Free Systems
- Integrative Genetics and Genomics, University of California Davis, Davis, CA (United States)
- Department of Biomedical Engineering, University of California Davis, Davis, CA (United States)
As mathematical models become more commonly integrated into the study of biology, a common language for describing biological processes is manifesting. Many tools have emerged for the simulation of in vivo synthetic biological systems, with only a few examples of prominent work done on predicting the dynamics of cell-free synthetic systems. At the same time, experimental biologists have begun to study dynamics of in vitro systems encapsulated by amphiphilic molecules, opening the door for the development of a new generation of biomimetic systems. In this review, we explore both in vivo and in vitro models of biochemical networks with a special focus on tools that could be applied to the construction of cell-free expression systems. We believe that quantitative studies of complex cellular mechanisms and pathways in synthetic systems can yield important insights into what makes cells different from conventional chemical systems.
- OSTI ID:
- 22688024
- Journal Information:
- Frontiers in Bioengineering and Biotechnology, Vol. 2; Other Information: Copyright (c) 2014 Lewis, Villarreal, Wu and Tan.; This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.; Country of input: International Atomic Energy Agency (IAEA); ISSN 2296-4185
- Country of Publication:
- Switzerland
- Language:
- English
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