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Title: Gene–arsenic interaction in longitudinal changes of blood pressure: Findings from the Health Effects of Arsenic Longitudinal Study (HEALS) in Bangladesh

Abstract

Cardiovascular disease (CVD) is the leading cause of morbidity and mortality worldwide and mounting evidence indicates that toxicant exposures can profoundly impact on CVD risk. Epidemiologic studies have suggested that arsenic (As) exposure is positively related to increases in blood pressure (BP), a primary CVD risk factor. However, evidence of whether genetic susceptibility can modify the association between As and BP is lacking. In this study, we used mixed effect models adjusted for potential confounders to examine the interaction between As exposure from well water and potential genetic modifiers on longitudinal change in BP over approximately 7 years of follow-up in 1137 subjects selected from the Health Effects of Arsenic Longitudinal Study (HEALS) cohort in Bangladesh. Genotyping was conducted for 235 SNPs in 18 genes related to As metabolism, oxidative stress and endothelial function. We observed interactions between 44 SNPs with well water As for one or more BP outcome measures (systolic, diastolic, or pulse pressure (PP)) over the course of follow-up. The interaction between CYBA rs3794624 and well water As on annual PP remained statistically significant after correction for multiple comparisons (FDR-adjusted p for interaction = 0.05). Among individuals with the rs3794624 variant genotype, well water As was associatedmore » with a 2.23 mm Hg (95% CI: 1.14–3.32) greater annual increase in PP, while among those with the wild type, well water As was associated with a 0.13 mm Hg (95% CI: 0.02–0.23) greater annual increase in PP. Our results suggest that genetic variability may contribute to As-associated increases in BP over time. - Highlights: • Arsenic (As) exposure has been associated with blood pressure increases over time. • Genetic polymorphisms may modify the association between As and blood pressure. • An interaction between CYBA rs3794624 and well As increased annual pulse pressure. • Genetic variants may contribute to As-related blood pressure increases over time.« less

Authors:
 [1];  [2];  [1]; ; ;  [3];  [4]; ; ;  [5];  [2];  [2];  [6]; ; ; ; ; ; ; more »;  [5];  [2];  [2]; ;  [6]; « less
  1. Department of Epidemiology, Geisel School of Medicine at Dartmouth, Lebanon, NH (United States)
  2. (United States)
  3. Department of Population Health, New York University School of Medicine, New York, NY (United States)
  4. The Leon H. Charney Division of Cardiology, Department of Medicine, New York University School of Medicine, New York, NY (United States)
  5. Department of Health Studies, The University of Chicago, Chicago, IL (United States)
  6. Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY (United States)
Publication Date:
OSTI Identifier:
22687770
Resource Type:
Journal Article
Journal Name:
Toxicology and Applied Pharmacology
Additional Journal Information:
Journal Volume: 288; Journal Issue: 1; Other Information: Copyright (c) 2015 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0041-008X
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; ARSENIC; BLOOD; BLOOD PRESSURE; CARDIOVASCULAR DISEASES; CHEMICAL VAPOR DEPOSITION; DISEASE INCIDENCE; GENES; GENETIC VARIABILITY; GENETICS; GENOTYPE; HEALTH HAZARDS

Citation Formats

Farzan, Shohreh F., Department of Population Health, New York University School of Medicine, New York, NY, Karagas, Margaret R., Jiang, Jieying, Wu, Fen, Liu, Mengling, Newman, Jonathan D., Jasmine, Farzana, Kibriya, Muhammad G., Paul-Brutus, Rachelle, Department of Medicine and Human Genetics, The University of Chicago, Chicago, IL, Department of Comprehensive Cancer Center, The University of Chicago, Chicago, IL, Parvez, Faruque, Argos, Maria, Bryan, Molly Scannell, Eunus, Mahbub, Ahmed, Alauddin, Islam, Tariqul, Rakibuz-Zaman, Muhammad, Hasan, Rabiul, Sarwar, Golam, Department of Medicine and Human Genetics, The University of Chicago, Chicago, IL, Department of Comprehensive Cancer Center, The University of Chicago, Chicago, IL, Slavkovich, Vesna, Graziano, Joseph, and and others. Gene–arsenic interaction in longitudinal changes of blood pressure: Findings from the Health Effects of Arsenic Longitudinal Study (HEALS) in Bangladesh. United States: N. p., 2015. Web. doi:10.1016/J.TAAP.2015.07.017.
Farzan, Shohreh F., Department of Population Health, New York University School of Medicine, New York, NY, Karagas, Margaret R., Jiang, Jieying, Wu, Fen, Liu, Mengling, Newman, Jonathan D., Jasmine, Farzana, Kibriya, Muhammad G., Paul-Brutus, Rachelle, Department of Medicine and Human Genetics, The University of Chicago, Chicago, IL, Department of Comprehensive Cancer Center, The University of Chicago, Chicago, IL, Parvez, Faruque, Argos, Maria, Bryan, Molly Scannell, Eunus, Mahbub, Ahmed, Alauddin, Islam, Tariqul, Rakibuz-Zaman, Muhammad, Hasan, Rabiul, Sarwar, Golam, Department of Medicine and Human Genetics, The University of Chicago, Chicago, IL, Department of Comprehensive Cancer Center, The University of Chicago, Chicago, IL, Slavkovich, Vesna, Graziano, Joseph, & and others. Gene–arsenic interaction in longitudinal changes of blood pressure: Findings from the Health Effects of Arsenic Longitudinal Study (HEALS) in Bangladesh. United States. doi:10.1016/J.TAAP.2015.07.017.
Farzan, Shohreh F., Department of Population Health, New York University School of Medicine, New York, NY, Karagas, Margaret R., Jiang, Jieying, Wu, Fen, Liu, Mengling, Newman, Jonathan D., Jasmine, Farzana, Kibriya, Muhammad G., Paul-Brutus, Rachelle, Department of Medicine and Human Genetics, The University of Chicago, Chicago, IL, Department of Comprehensive Cancer Center, The University of Chicago, Chicago, IL, Parvez, Faruque, Argos, Maria, Bryan, Molly Scannell, Eunus, Mahbub, Ahmed, Alauddin, Islam, Tariqul, Rakibuz-Zaman, Muhammad, Hasan, Rabiul, Sarwar, Golam, Department of Medicine and Human Genetics, The University of Chicago, Chicago, IL, Department of Comprehensive Cancer Center, The University of Chicago, Chicago, IL, Slavkovich, Vesna, Graziano, Joseph, and and others. Thu . "Gene–arsenic interaction in longitudinal changes of blood pressure: Findings from the Health Effects of Arsenic Longitudinal Study (HEALS) in Bangladesh". United States. doi:10.1016/J.TAAP.2015.07.017.
@article{osti_22687770,
title = {Gene–arsenic interaction in longitudinal changes of blood pressure: Findings from the Health Effects of Arsenic Longitudinal Study (HEALS) in Bangladesh},
author = {Farzan, Shohreh F. and Department of Population Health, New York University School of Medicine, New York, NY and Karagas, Margaret R. and Jiang, Jieying and Wu, Fen and Liu, Mengling and Newman, Jonathan D. and Jasmine, Farzana and Kibriya, Muhammad G. and Paul-Brutus, Rachelle and Department of Medicine and Human Genetics, The University of Chicago, Chicago, IL and Department of Comprehensive Cancer Center, The University of Chicago, Chicago, IL and Parvez, Faruque and Argos, Maria and Bryan, Molly Scannell and Eunus, Mahbub and Ahmed, Alauddin and Islam, Tariqul and Rakibuz-Zaman, Muhammad and Hasan, Rabiul and Sarwar, Golam and Department of Medicine and Human Genetics, The University of Chicago, Chicago, IL and Department of Comprehensive Cancer Center, The University of Chicago, Chicago, IL and Slavkovich, Vesna and Graziano, Joseph and and others},
abstractNote = {Cardiovascular disease (CVD) is the leading cause of morbidity and mortality worldwide and mounting evidence indicates that toxicant exposures can profoundly impact on CVD risk. Epidemiologic studies have suggested that arsenic (As) exposure is positively related to increases in blood pressure (BP), a primary CVD risk factor. However, evidence of whether genetic susceptibility can modify the association between As and BP is lacking. In this study, we used mixed effect models adjusted for potential confounders to examine the interaction between As exposure from well water and potential genetic modifiers on longitudinal change in BP over approximately 7 years of follow-up in 1137 subjects selected from the Health Effects of Arsenic Longitudinal Study (HEALS) cohort in Bangladesh. Genotyping was conducted for 235 SNPs in 18 genes related to As metabolism, oxidative stress and endothelial function. We observed interactions between 44 SNPs with well water As for one or more BP outcome measures (systolic, diastolic, or pulse pressure (PP)) over the course of follow-up. The interaction between CYBA rs3794624 and well water As on annual PP remained statistically significant after correction for multiple comparisons (FDR-adjusted p for interaction = 0.05). Among individuals with the rs3794624 variant genotype, well water As was associated with a 2.23 mm Hg (95% CI: 1.14–3.32) greater annual increase in PP, while among those with the wild type, well water As was associated with a 0.13 mm Hg (95% CI: 0.02–0.23) greater annual increase in PP. Our results suggest that genetic variability may contribute to As-associated increases in BP over time. - Highlights: • Arsenic (As) exposure has been associated with blood pressure increases over time. • Genetic polymorphisms may modify the association between As and blood pressure. • An interaction between CYBA rs3794624 and well As increased annual pulse pressure. • Genetic variants may contribute to As-related blood pressure increases over time.},
doi = {10.1016/J.TAAP.2015.07.017},
journal = {Toxicology and Applied Pharmacology},
issn = {0041-008X},
number = 1,
volume = 288,
place = {United States},
year = {2015},
month = {10}
}