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Title: Exposure to polychlorinated biphenyls and the thyroid gland – examining and discussing possible longitudinal health effects in humans

Abstract

Background: Many previous studies have dealt with the effect of polychlorinated biphenyls (PCBs) on the thyroid gland, but their findings are inconsistent. One problem of these studies has been their use of cross-sectional designs. Objectives: The aim of the current study is to investigate longitudinal effects of PCBs on the thyroid gland, focusing on: morphological changes in thyroid tissue (i.e. thyroid volume), changes in thyroid hormones and in thyroid antibodies. Methods: A total of 122 individuals (M{sub age}=44.7) were examined over a period of four years (t{sup 1} until t{sup 4}). Medical history was collected via interviews, an ultrasound examination was performed and blood samples were taken to determine plasma PCB levels, thyroid stimulating hormone (TSH), free triiodthyronine (fT3), free thyroxine (fT4), thyroid peroxidase antibodies (TPOab), thyreoglobulin antibodies (TGab) and thyroid-stimulating hormone receptor antibodies (TSHRab). Rank correlation coefficients and mixed effect models were performed controlling for age and total lipids. Results: There were negative correlations between higher chlorinated biphenyls and fT3, cross-sectionally as well as longitudinally. We also found an interaction effect of higher-chlorinated PCBs over time for fT4 as well as TSHRab. In case of high exposure, a decrease in fT4 and an increase in TSHRab level were foundmore » over time. In regards to the other variables, our findings yielded no clear results in the examined time period. Conclusion: This is the first study to shows a PCB-related effect on fT3, fT4 and TSHRab over a four year period. The data also suggest that morphological and antibody findings remain inconsistent and do not allow for unambiguous interpretation. - Highlights: • This is a longitudinal study which includes data from four cross sections. • Higher-chlorinated biphenyls are negatively correlated with fT3. • There are interactions of time and higher-chlorinated biphenyls to TSHRab and fT4. • There is an interaction of time and dioxin-like polychlorinated biphenyls to fT4. • No consistent effects were found for thyroid volume, TSH, TPOab and TGab.« less

Authors:
 [1]; ; ;  [1];  [2]; ;  [1]
  1. Institute for Occupational and Social Medicine, RWTH Aachen University, Pauwelsstraße 30, D-52074 Aachen (Germany)
  2. Clinic for Gynaecological Endocrinology and Reproductive Medicine, RWTH Aachen University, Pauwelsstraße 30, D-52074 Aachen (Germany)
Publication Date:
OSTI Identifier:
22687745
Resource Type:
Journal Article
Journal Name:
Environmental Research
Additional Journal Information:
Journal Volume: 148; Other Information: Copyright (c) 2016 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0013-9351
Country of Publication:
United States
Language:
English
Subject:
54 ENVIRONMENTAL SCIENCES; ANTIBODIES; BIPHENYL; MORPHOLOGICAL CHANGES; PEROXIDASES; POLYCHLORINATED BIPHENYLS; THYROID; THYROXINE; TSH

Citation Formats

Gaum, Petra M., E-mail: pgaum@ukaachen.de, Lang, Jessica, Esser, André, Schettgen, Thomas, Neulen, Joseph, Kraus, Thomas, and Gube, Monika. Exposure to polychlorinated biphenyls and the thyroid gland – examining and discussing possible longitudinal health effects in humans. United States: N. p., 2016. Web. doi:10.1016/J.ENVRES.2016.03.022.
Gaum, Petra M., E-mail: pgaum@ukaachen.de, Lang, Jessica, Esser, André, Schettgen, Thomas, Neulen, Joseph, Kraus, Thomas, & Gube, Monika. Exposure to polychlorinated biphenyls and the thyroid gland – examining and discussing possible longitudinal health effects in humans. United States. doi:10.1016/J.ENVRES.2016.03.022.
Gaum, Petra M., E-mail: pgaum@ukaachen.de, Lang, Jessica, Esser, André, Schettgen, Thomas, Neulen, Joseph, Kraus, Thomas, and Gube, Monika. Fri . "Exposure to polychlorinated biphenyls and the thyroid gland – examining and discussing possible longitudinal health effects in humans". United States. doi:10.1016/J.ENVRES.2016.03.022.
@article{osti_22687745,
title = {Exposure to polychlorinated biphenyls and the thyroid gland – examining and discussing possible longitudinal health effects in humans},
author = {Gaum, Petra M., E-mail: pgaum@ukaachen.de and Lang, Jessica and Esser, André and Schettgen, Thomas and Neulen, Joseph and Kraus, Thomas and Gube, Monika},
abstractNote = {Background: Many previous studies have dealt with the effect of polychlorinated biphenyls (PCBs) on the thyroid gland, but their findings are inconsistent. One problem of these studies has been their use of cross-sectional designs. Objectives: The aim of the current study is to investigate longitudinal effects of PCBs on the thyroid gland, focusing on: morphological changes in thyroid tissue (i.e. thyroid volume), changes in thyroid hormones and in thyroid antibodies. Methods: A total of 122 individuals (M{sub age}=44.7) were examined over a period of four years (t{sup 1} until t{sup 4}). Medical history was collected via interviews, an ultrasound examination was performed and blood samples were taken to determine plasma PCB levels, thyroid stimulating hormone (TSH), free triiodthyronine (fT3), free thyroxine (fT4), thyroid peroxidase antibodies (TPOab), thyreoglobulin antibodies (TGab) and thyroid-stimulating hormone receptor antibodies (TSHRab). Rank correlation coefficients and mixed effect models were performed controlling for age and total lipids. Results: There were negative correlations between higher chlorinated biphenyls and fT3, cross-sectionally as well as longitudinally. We also found an interaction effect of higher-chlorinated PCBs over time for fT4 as well as TSHRab. In case of high exposure, a decrease in fT4 and an increase in TSHRab level were found over time. In regards to the other variables, our findings yielded no clear results in the examined time period. Conclusion: This is the first study to shows a PCB-related effect on fT3, fT4 and TSHRab over a four year period. The data also suggest that morphological and antibody findings remain inconsistent and do not allow for unambiguous interpretation. - Highlights: • This is a longitudinal study which includes data from four cross sections. • Higher-chlorinated biphenyls are negatively correlated with fT3. • There are interactions of time and higher-chlorinated biphenyls to TSHRab and fT4. • There is an interaction of time and dioxin-like polychlorinated biphenyls to fT4. • No consistent effects were found for thyroid volume, TSH, TPOab and TGab.},
doi = {10.1016/J.ENVRES.2016.03.022},
journal = {Environmental Research},
issn = {0013-9351},
number = ,
volume = 148,
place = {United States},
year = {2016},
month = {7}
}