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Title: Pencil beam scanning proton therapy vs rotational arc radiation therapy: A treatment planning comparison for postoperative oropharyngeal cancer

Abstract

Patients diagnosed with head and neck cancer are traditionally treated with photon radiotherapy. Proton therapy is currently being used clinically and may potentially reduce treatment-related toxicities by minimizing the dose to normal organs in the treatment of postoperative oropharyngeal cancer. The finite range of protons has the potential to significantly reduce normal tissue toxicity compared to photon radiotherapy. Seven patients were planned with both proton and photon modalities. The planning goal for both modalities was achieving the prescribed dose to 95% of the planning target volume (PTV). Dose-volume histograms were compared in which all cases met the target coverage goals. Mean doses were significantly lower in the proton plans for the oral cavity (1771 cGy photon vs 293 cGy proton, p < 0.001), contralateral parotid (1796 cGy photon vs 1358 proton, p < 0.001), and the contralateral submandibular gland (3608 cGy photon vs 3251 cGy proton, p = 0.03). Average total integral dose was 9.1% lower in proton plans. The significant dosimetric sparing seen with proton therapy may lead to reduced side effects such as pain, weight loss, taste changes, and dry mouth. Prospective comparisons of protons vs photons for disease control, toxicity, and patient-reported outcomes are therefore warranted andmore » currently being pursued.« less

Authors:
; ; ; ; ;
Publication Date:
OSTI Identifier:
22685174
Resource Type:
Journal Article
Resource Relation:
Journal Name: Medical Dosimetry; Journal Volume: 42; Journal Issue: 1; Other Information: Copyright (c) 2017 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
61 RADIATION PROTECTION AND DOSIMETRY; 62 RADIOLOGY AND NUCLEAR MEDICINE; ANIMAL TISSUES; COMPARATIVE EVALUATIONS; DIAGNOSIS; GLANDS; HEAD; INTEGRAL DOSES; NECK; NEOPLASMS; ORAL CAVITY; PATIENTS; PHOTONS; PLANNING; PROTON BEAMS; RADIOTHERAPY; SIDE EFFECTS; TOXICITY

Citation Formats

Apinorasethkul, Ontida, E-mail: Ontida.a@gmail.com, Kirk, Maura, Teo, Kevin, Swisher-McClure, Samuel, Lukens, John N., and Lin, Alexander. Pencil beam scanning proton therapy vs rotational arc radiation therapy: A treatment planning comparison for postoperative oropharyngeal cancer. United States: N. p., 2017. Web. doi:10.1016/J.MEDDOS.2016.09.004.
Apinorasethkul, Ontida, E-mail: Ontida.a@gmail.com, Kirk, Maura, Teo, Kevin, Swisher-McClure, Samuel, Lukens, John N., & Lin, Alexander. Pencil beam scanning proton therapy vs rotational arc radiation therapy: A treatment planning comparison for postoperative oropharyngeal cancer. United States. doi:10.1016/J.MEDDOS.2016.09.004.
Apinorasethkul, Ontida, E-mail: Ontida.a@gmail.com, Kirk, Maura, Teo, Kevin, Swisher-McClure, Samuel, Lukens, John N., and Lin, Alexander. Sat . "Pencil beam scanning proton therapy vs rotational arc radiation therapy: A treatment planning comparison for postoperative oropharyngeal cancer". United States. doi:10.1016/J.MEDDOS.2016.09.004.
@article{osti_22685174,
title = {Pencil beam scanning proton therapy vs rotational arc radiation therapy: A treatment planning comparison for postoperative oropharyngeal cancer},
author = {Apinorasethkul, Ontida, E-mail: Ontida.a@gmail.com and Kirk, Maura and Teo, Kevin and Swisher-McClure, Samuel and Lukens, John N. and Lin, Alexander},
abstractNote = {Patients diagnosed with head and neck cancer are traditionally treated with photon radiotherapy. Proton therapy is currently being used clinically and may potentially reduce treatment-related toxicities by minimizing the dose to normal organs in the treatment of postoperative oropharyngeal cancer. The finite range of protons has the potential to significantly reduce normal tissue toxicity compared to photon radiotherapy. Seven patients were planned with both proton and photon modalities. The planning goal for both modalities was achieving the prescribed dose to 95% of the planning target volume (PTV). Dose-volume histograms were compared in which all cases met the target coverage goals. Mean doses were significantly lower in the proton plans for the oral cavity (1771 cGy photon vs 293 cGy proton, p < 0.001), contralateral parotid (1796 cGy photon vs 1358 proton, p < 0.001), and the contralateral submandibular gland (3608 cGy photon vs 3251 cGy proton, p = 0.03). Average total integral dose was 9.1% lower in proton plans. The significant dosimetric sparing seen with proton therapy may lead to reduced side effects such as pain, weight loss, taste changes, and dry mouth. Prospective comparisons of protons vs photons for disease control, toxicity, and patient-reported outcomes are therefore warranted and currently being pursued.},
doi = {10.1016/J.MEDDOS.2016.09.004},
journal = {Medical Dosimetry},
number = 1,
volume = 42,
place = {United States},
year = {Sat Apr 01 00:00:00 EDT 2017},
month = {Sat Apr 01 00:00:00 EDT 2017}
}