TH-CD-BRA-02: 3D Remote Dosimetry for MRI-Guided Radiation Therapy: A Hybrid Approach

Rankine, L; Mein, S; Juang, T; Miles, D; Adamovics, J; Cai, B; Curcuru, A; Mutic, S; Wang, Y; Li, H; Oldham, M

doi:10.1118/1.4958145

Title: TH-CD-BRA-02: 3D Remote Dosimetry for MRI-Guided Radiation Therapy: A Hybrid Approach

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Abstract

Purpose: To validate the dosimetric accuracy of a commercially available MR-IGRT system using a combination of 3D dosimetry measurements (with PRESAGE(R) radiochromic plastic and optical-CT readout) and an in-house developed GPU-accelerated PENELOPE Monte-Carlo dose calculation system. Methods: {sup 60}Co IMRT subject to a 0.35T lateral magnetic field has recently been commissioned in our institution following AAPM’s TG-119 recommendations. We performed PRESAGE(R) sensitivity studies in 4ml cuvettes to verify linearity, MR-compatibility, and energy-independence. Using 10cm diameter PRESAGE(R), we delivered an open calibration field to examine the percent depth dose and a symmetrical 3-field plan with three adjacent regions of varying dose to determine uniformity within the dosimeter under a magnetic field. After initial testing, TG-119 plans were created in the TPS and then delivered to 14.5cm 2kg PRESAGE(R) dosimeters. Dose readout was performed via optical-CT at a second institution specializing in remote 3D dosimetry. Absolute dose was measured using an IBA CC01 ion chamber and the institution standard patient-specific QA methods were used to validate plan delivery. Calculated TG-119 plans were then compared with an independent Monte Carlo dose calculation (gPENELOPE). Results: PRESAGE(R) responds linearly (R{sup 2}=0.9996) to {sup 60}Co irradiation, in the presence of a 0.35T magnetic field, with amore »« less

Authors:

Rankine, L ^[1]; Mein, S; Juang, T; Miles, D ^[2]; Adamovics, J ^[3]; Cai, B; Curcuru, A; Mutic, S; Wang, Y; Li, H ^[1]; Oldham, M ^[4]

Washington University School of Medicine, Saint Louis, MO (United States)
Duke University Medical Physics Graduate Program, Durham, NC (United States)
Rider University, Skillman, NJ (United States)
Duke University Medical Center, Durham, NC (United States)

Publication Date:: Wed Jun 15 00:00:00 EDT 2016

OSTI Identifier:: 22679287

Resource Type:: Journal Article

Journal Name:: Medical Physics

Additional Journal Information:: Journal Volume: 43; Journal Issue: 6; Other Information: (c) 2016 American Association of Physicists in Medicine; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0094-2405

Country of Publication:: United States

Language:: English

Subject:: 60 APPLIED LIFE SCIENCES; 61 RADIATION PROTECTION AND DOSIMETRY; COBALT 60; DEPTH DOSE DISTRIBUTIONS; DOSIMETRY; IONIZATION CHAMBERS; LINEAR ACCELERATORS; MAGNETIC FIELDS; MONTE CARLO METHOD; RADIOTHERAPY; READOUT SYSTEMS; TESTING

Citation Formats


                    Rankine, L, The University of North Carolina at Chapel Hill, Chapel Hill, NC, Mein, S, Juang, T, Miles, D, Adamovics, J, Cai, B, Curcuru, A, Mutic, S, Wang, Y, Li, H, and Oldham, M. TH-CD-BRA-02: 3D Remote Dosimetry for MRI-Guided Radiation Therapy: A Hybrid Approach.  United States: N. p., 2016. 
        Web.  doi:10.1118/1.4958145.

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                    Rankine, L, The University of North Carolina at Chapel Hill, Chapel Hill, NC, Mein, S, Juang, T, Miles, D, Adamovics, J, Cai, B, Curcuru, A, Mutic, S, Wang, Y, Li, H, & Oldham, M. TH-CD-BRA-02: 3D Remote Dosimetry for MRI-Guided Radiation Therapy: A Hybrid Approach.  United States.  https://doi.org/10.1118/1.4958145

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                    Rankine, L, The University of North Carolina at Chapel Hill, Chapel Hill, NC, Mein, S, Juang, T, Miles, D, Adamovics, J, Cai, B, Curcuru, A, Mutic, S, Wang, Y, Li, H, and Oldham, M. 2016.  
        "TH-CD-BRA-02: 3D Remote Dosimetry for MRI-Guided Radiation Therapy: A Hybrid Approach".  United States.  https://doi.org/10.1118/1.4958145.

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@article{osti_22679287,

  title        = {TH-CD-BRA-02: 3D Remote Dosimetry for MRI-Guided Radiation Therapy: A Hybrid Approach},

  author       = {Rankine, L and The University of North Carolina at Chapel Hill, Chapel Hill, NC and Mein, S and Juang, T and Miles, D and Adamovics, J and Cai, B and Curcuru, A and Mutic, S and Wang, Y and Li, H and Oldham, M},

  abstractNote = {Purpose: To validate the dosimetric accuracy of a commercially available MR-IGRT system using a combination of 3D dosimetry measurements (with PRESAGE(R) radiochromic plastic and optical-CT readout) and an in-house developed GPU-accelerated PENELOPE Monte-Carlo dose calculation system. Methods: {sup 60}Co IMRT subject to a 0.35T lateral magnetic field has recently been commissioned in our institution following AAPM’s TG-119 recommendations. We performed PRESAGE(R) sensitivity studies in 4ml cuvettes to verify linearity, MR-compatibility, and energy-independence. Using 10cm diameter PRESAGE(R), we delivered an open calibration field to examine the percent depth dose and a symmetrical 3-field plan with three adjacent regions of varying dose to determine uniformity within the dosimeter under a magnetic field. After initial testing, TG-119 plans were created in the TPS and then delivered to 14.5cm 2kg PRESAGE(R) dosimeters. Dose readout was performed via optical-CT at a second institution specializing in remote 3D dosimetry. Absolute dose was measured using an IBA CC01 ion chamber and the institution standard patient-specific QA methods were used to validate plan delivery. Calculated TG-119 plans were then compared with an independent Monte Carlo dose calculation (gPENELOPE). Results: PRESAGE(R) responds linearly (R{sup 2}=0.9996) to {sup 60}Co irradiation, in the presence of a 0.35T magnetic field, with a sensitivity of 0.0305(±0.003)cm{sup −1}Gy{sup −1}, within 1% of a 6MV non-MR linac irradiation (R{sup 2}=0.9991) with a sensitivity of 0.0302(±0.003)cm{sup −1}Gy{sup −1}. Analysis of TG-119 clinical plans using 3D-gamma (3%/3mm, 10% threshold) give passing rates of: HN 99.1%, prostate 98.0%, C-shape 90.8%, and multi-target 98.5%. The TPS agreed with gPENELOPE with a mean gamma passing rate of 98.4±1.5% (2%/2mm) with the z-score distributions following a standard normal distribution. Conclusion: We demonstrate for the first time that 3D remote dosimetry using both experimental and computational methods is a feasible and reliable approach to commissioning MR-IMRT, which is particularly useful for less specialized clinics in adopting this new treatment modality.},

  doi          = {10.1118/1.4958145},

  url          = {https://www.osti.gov/biblio/22679287},
  journal      = {Medical Physics},

  issn         = {0094-2405},

  number       = 6,

  volume       = 43,

  place        = {United States},

  year         = {Wed Jun 15 00:00:00 EDT 2016},

  month        = {Wed Jun 15 00:00:00 EDT 2016}

}

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