WE-FG-BRA-09: Using Graphene Oxide Nano Flakes During Image Guided Radiotherapy to Minimize the Potential of Cancer Recurrence Or Metastasis

Toomeh, D; Sajo, E; Hao, Y; Gadoue, S; Ngwa, W

doi:10.1118/1.4957909

Title: WE-FG-BRA-09: Using Graphene Oxide Nano Flakes During Image Guided Radiotherapy to Minimize the Potential of Cancer Recurrence Or Metastasis

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Abstract

Purpose: An increasing number of studies show that cancer stem cells (CSCs) become more invasive (metastatic) and may escape into the blood stream and lymph nodes during radiotherapy (RT), before they have received a lethal dose during RT. Other Studies have shown that Graphene oxide (GO) can selectively inhibit the proliferative expansion of CSCs across multiplicative tumor types. In this study we investigate the feasibility of using GO during radiotherapy (RT) to minimize the escape of CSCs towards preventing cancer metastasis or recurrence. Methods: We hypothesize that sufficient amount of GO nano-flakes (GONFs) released from new design radiotherapy biomaterials (fiducials or spacers) loaded with the GONFs can reach all tumor cells within typical times of 14 or 21days before the beginning of image-guided radiotherapy (IGRT) following implantation. To test this hypothesis, the space-time diffusion of the GONFs was investigated. Knudsen’s and Cunningham’s numbers were calculated to get the Stokes’ velocities and mobility values, according to these values, diffusion coefficients were calculated. In a previous study it was shown that GONFs concentration of 50 µg/ml were effective. In the diffusion study, 100 µg/ml was chosen as an initial concentration because it has been shown to be relatively non-toxic. Results: The 50more »« less

Authors:

Toomeh, D; Sajo, E; Hao, Y; Gadoue, S ^[1]; Ngwa, W ^[1]

University Massachusetts Lowell, Lowell, MA (United States)

Publication Date:: Wed Jun 15 00:00:00 EDT 2016

OSTI Identifier:: 22679078

Resource Type:: Journal Article

Journal Name:: Medical Physics

Additional Journal Information:: Journal Volume: 43; Journal Issue: 6; Other Information: (c) 2016 American Association of Physicists in Medicine; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0094-2405

Country of Publication:: United States

Language:: English

Subject:: 60 APPLIED LIFE SCIENCES; 61 RADIATION PROTECTION AND DOSIMETRY; CONCENTRATION RATIO; DIFFUSION; ECOLOGICAL CONCENTRATION; GRAPHENE; IN VIVO; LETHAL DOSES; LYMPH NODES; METASTASES; NEOPLASMS; OXIDES; POTENTIALS; RADIOTHERAPY; STEM CELLS; TUMOR CELLS

Citation Formats


                    Toomeh, D, Sajo, E, Hao, Y, Gadoue, S, Ngwa, W, and Harvard Medical School, Boston, MA. WE-FG-BRA-09: Using Graphene Oxide Nano Flakes During Image Guided Radiotherapy to Minimize the Potential of Cancer Recurrence Or Metastasis.  United States: N. p., 2016. 
        Web.  doi:10.1118/1.4957909.

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                    Toomeh, D, Sajo, E, Hao, Y, Gadoue, S, Ngwa, W, & Harvard Medical School, Boston, MA. WE-FG-BRA-09: Using Graphene Oxide Nano Flakes During Image Guided Radiotherapy to Minimize the Potential of Cancer Recurrence Or Metastasis.  United States.  https://doi.org/10.1118/1.4957909

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                    Toomeh, D, Sajo, E, Hao, Y, Gadoue, S, Ngwa, W, and Harvard Medical School, Boston, MA. 2016.  
        "WE-FG-BRA-09: Using Graphene Oxide Nano Flakes During Image Guided Radiotherapy to Minimize the Potential of Cancer Recurrence Or Metastasis".  United States.  https://doi.org/10.1118/1.4957909.

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@article{osti_22679078,

  title        = {WE-FG-BRA-09: Using Graphene Oxide Nano Flakes During Image Guided Radiotherapy to Minimize the Potential of Cancer Recurrence Or Metastasis},

  author       = {Toomeh, D and Sajo, E and Hao, Y and Gadoue, S and Ngwa, W and Harvard Medical School, Boston, MA},

  abstractNote = {Purpose: An increasing number of studies show that cancer stem cells (CSCs) become more invasive (metastatic) and may escape into the blood stream and lymph nodes during radiotherapy (RT), before they have received a lethal dose during RT. Other Studies have shown that Graphene oxide (GO) can selectively inhibit the proliferative expansion of CSCs across multiplicative tumor types. In this study we investigate the feasibility of using GO during radiotherapy (RT) to minimize the escape of CSCs towards preventing cancer metastasis or recurrence. Methods: We hypothesize that sufficient amount of GO nano-flakes (GONFs) released from new design radiotherapy biomaterials (fiducials or spacers) loaded with the GONFs can reach all tumor cells within typical times of 14 or 21days before the beginning of image-guided radiotherapy (IGRT) following implantation. To test this hypothesis, the space-time diffusion of the GONFs was investigated. Knudsen’s and Cunningham’s numbers were calculated to get the Stokes’ velocities and mobility values, according to these values, diffusion coefficients were calculated. In a previous study it was shown that GONFs concentration of 50 µg/ml were effective. In the diffusion study, 100 µg/ml was chosen as an initial concentration because it has been shown to be relatively non-toxic. Results: The 50 µg/ml concentration in a 2 cm diameter volume of lung tumor could be only achieved using 2 nm and 6 nm GONFs with respective diffusion times of 14 and 21 days. As expected, increased nanoflake size requires longer times to achieve the target 50 µg/ml concentration. Conclusion: The preliminary results indicate the potential of using GONFs delivered via new design radiotherapy biomaterials (e.g. fiducials) to inhibit the proliferative expansion of CSCs. The study avails ongoing in-vivo studies on using GONFs to enhance treatment outcomes for cancer patients.},

  doi          = {10.1118/1.4957909},

  url          = {https://www.osti.gov/biblio/22679078},
  journal      = {Medical Physics},

  issn         = {0094-2405},

  number       = 6,

  volume       = 43,

  place        = {United States},

  year         = {Wed Jun 15 00:00:00 EDT 2016},

  month        = {Wed Jun 15 00:00:00 EDT 2016}

}

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