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Title: TU-H-BRC-07: Therapeutic Benefit in Spatially Fractionated Radiotherapy (GRID) Using Helical Tomotherapy

Abstract

Purpose: The aim of this project is to study the therapeutic ratio (TR) for helical Tomotherapy (HT) based spatially fractionated radiotherapy (GRID). Estimation of TR was based on the linear-quadratic cell survival model by comparing the normal cell survival in a HT GRID to that of a uniform dose delivery in an open-field for the same tumor survival. Methods: HT GRID plan was generated using a patient specific virtual GRID block pattern of non-divergent, cylinder shaped holes using MLCs. TR was defined as the ratio of normal tissue surviving fraction (SF) under HT GRID irradiation to an open field irradiation with an equivalent dose that result in the same tumor cell SF. The ratio was estimated from DVH data on ten patient plans with deep seated, bulky tumor approved by the treating radiation oncologist. Dependence of the TR values on radio-sensitivity of the tumor cells and prescription dose were also analyzed. Results: The mean ± standard deviation (SD) of TR was 4.0±0.7 (range: 3.1 to 5.5) for the 10 patients with single fraction dose of 20 Gy and tumor cell SF of 0.5 at 2 Gy. In addition, mean±SD of TR = 1±0.1 and 18.0±5.1 were found for tumor withmore » SF of 0.3 and 0.7, respectively. Reducing the prescription dose to 15 and 10 Gy lowered the TR to 2.0±0.2 and 1.2±0.04 for a tumor cell SF of 0.5 at 2 Gy. In this study, the SF of normal cells was assumed to be 0.5 at 2 Gy. Conclusion: HT GRID displayed a significant therapeutic advantage over uniform dose from an open field irradiation. TR increases with the radioresistance of the tumor cells and with prescription dose.« less

Authors:
; ; ; ; ; ;  [1];  [2];  [3];  [1];  [3]
  1. Department of Radiation Oncology, University of Arkansas for Medical Sciences, Little Rock, AR (United States)
  2. Comprehensive Cancer Center of Nevada, Las Vegas, NV (United States)
  3. (United States)
Publication Date:
OSTI Identifier:
22654021
Resource Type:
Journal Article
Resource Relation:
Journal Name: Medical Physics; Journal Volume: 43; Journal Issue: 6; Other Information: (c) 2016 American Association of Physicists in Medicine; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; 61 RADIATION PROTECTION AND DOSIMETRY; COMPUTERIZED TOMOGRAPHY; CT-GUIDED RADIOTHERAPY; DOSE EQUIVALENTS; GRIDS; HIGH-TC SUPERCONDUCTORS; IRRADIATION; NEOPLASMS; PATIENTS; TUMOR CELLS

Citation Formats

Narayanasamy, G, Zhang, X, Paudel, N, Morrill, S, Maraboyina, S, Peacock, L, Penagaricano, J, Meigooni, A, Department of Radiation Oncology, University of Nevada Las Vegas, NV, Liang, X, and University of Florida Health Proton Therapy Institute, Jacksonville, FL. TU-H-BRC-07: Therapeutic Benefit in Spatially Fractionated Radiotherapy (GRID) Using Helical Tomotherapy. United States: N. p., 2016. Web. doi:10.1118/1.4957614.
Narayanasamy, G, Zhang, X, Paudel, N, Morrill, S, Maraboyina, S, Peacock, L, Penagaricano, J, Meigooni, A, Department of Radiation Oncology, University of Nevada Las Vegas, NV, Liang, X, & University of Florida Health Proton Therapy Institute, Jacksonville, FL. TU-H-BRC-07: Therapeutic Benefit in Spatially Fractionated Radiotherapy (GRID) Using Helical Tomotherapy. United States. doi:10.1118/1.4957614.
Narayanasamy, G, Zhang, X, Paudel, N, Morrill, S, Maraboyina, S, Peacock, L, Penagaricano, J, Meigooni, A, Department of Radiation Oncology, University of Nevada Las Vegas, NV, Liang, X, and University of Florida Health Proton Therapy Institute, Jacksonville, FL. Wed . "TU-H-BRC-07: Therapeutic Benefit in Spatially Fractionated Radiotherapy (GRID) Using Helical Tomotherapy". United States. doi:10.1118/1.4957614.
@article{osti_22654021,
title = {TU-H-BRC-07: Therapeutic Benefit in Spatially Fractionated Radiotherapy (GRID) Using Helical Tomotherapy},
author = {Narayanasamy, G and Zhang, X and Paudel, N and Morrill, S and Maraboyina, S and Peacock, L and Penagaricano, J and Meigooni, A and Department of Radiation Oncology, University of Nevada Las Vegas, NV and Liang, X and University of Florida Health Proton Therapy Institute, Jacksonville, FL},
abstractNote = {Purpose: The aim of this project is to study the therapeutic ratio (TR) for helical Tomotherapy (HT) based spatially fractionated radiotherapy (GRID). Estimation of TR was based on the linear-quadratic cell survival model by comparing the normal cell survival in a HT GRID to that of a uniform dose delivery in an open-field for the same tumor survival. Methods: HT GRID plan was generated using a patient specific virtual GRID block pattern of non-divergent, cylinder shaped holes using MLCs. TR was defined as the ratio of normal tissue surviving fraction (SF) under HT GRID irradiation to an open field irradiation with an equivalent dose that result in the same tumor cell SF. The ratio was estimated from DVH data on ten patient plans with deep seated, bulky tumor approved by the treating radiation oncologist. Dependence of the TR values on radio-sensitivity of the tumor cells and prescription dose were also analyzed. Results: The mean ± standard deviation (SD) of TR was 4.0±0.7 (range: 3.1 to 5.5) for the 10 patients with single fraction dose of 20 Gy and tumor cell SF of 0.5 at 2 Gy. In addition, mean±SD of TR = 1±0.1 and 18.0±5.1 were found for tumor with SF of 0.3 and 0.7, respectively. Reducing the prescription dose to 15 and 10 Gy lowered the TR to 2.0±0.2 and 1.2±0.04 for a tumor cell SF of 0.5 at 2 Gy. In this study, the SF of normal cells was assumed to be 0.5 at 2 Gy. Conclusion: HT GRID displayed a significant therapeutic advantage over uniform dose from an open field irradiation. TR increases with the radioresistance of the tumor cells and with prescription dose.},
doi = {10.1118/1.4957614},
journal = {Medical Physics},
number = 6,
volume = 43,
place = {United States},
year = {Wed Jun 15 00:00:00 EDT 2016},
month = {Wed Jun 15 00:00:00 EDT 2016}
}