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Title: Patient-Reported Outcomes After Radiation Therapy in Men With Prostate Cancer: A Systematic Review of Prognostic Tool Accuracy and Validity

Abstract

Purpose: To identify, through a systematic review, all validated tools used for the prediction of patient-reported outcome measures (PROMs) in patients being treated with radiation therapy for prostate cancer, and provide a comparative summary of accuracy and generalizability. Methods and Materials: PubMed and EMBASE were searched from July 2007. Title/abstract screening, full text review, and critical appraisal were undertaken by 2 reviewers, whereas data extraction was performed by a single reviewer. Eligible articles had to provide a summary measure of accuracy and undertake internal or external validation. Tools were recommended for clinical implementation if they had been externally validated and found to have accuracy ≥70%. Results: The search strategy identified 3839 potential studies, of which 236 progressed to full text review and 22 were included. From these studies, 50 tools predicted gastrointestinal/rectal symptoms, 29 tools predicted genitourinary symptoms, 4 tools predicted erectile dysfunction, and no tools predicted quality of life. For patients treated with external beam radiation therapy, 3 tools could be recommended for the prediction of rectal toxicity, gastrointestinal toxicity, and erectile dysfunction. For patients treated with brachytherapy, 2 tools could be recommended for the prediction of urinary retention and erectile dysfunction. Conclusions: A large number of tools for themore » prediction of PROMs in prostate cancer patients treated with radiation therapy have been developed. Only a small minority are accurate and have been shown to be generalizable through external validation. This review provides an accessible catalogue of tools that are ready for clinical implementation as well as which should be prioritized for validation.« less

Authors:
 [1];  [2];  [2];  [1];  [3];  [4];  [1];  [2];  [5]; ;  [6];  [7];  [6];  [1];  [2];  [1];  [2];  [2];  [2]
  1. South Australian Prostate Cancer Clinical Outcomes Collaborative (Australia)
  2. (Australia)
  3. Joanna Briggs Institute, University of Adelaide (Australia)
  4. Freemasons Foundation Centre for Men's Health, University of Adelaide (Australia)
  5. Centre for Population Health Research, University of South Australia (Australia)
  6. Epidemiology and Preventative Medicine, Monash University (Australia)
  7. Radiation Oncology, Alfred Health (Australia)
Publication Date:
OSTI Identifier:
22649929
Resource Type:
Journal Article
Resource Relation:
Journal Name: International Journal of Radiation Oncology, Biology and Physics; Journal Volume: 98; Journal Issue: 2; Other Information: Copyright (c) 2017 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; BRACHYTHERAPY; COST ESTIMATION; EXTERNAL BEAM RADIATION THERAPY; FORECASTING; NEOPLASMS; PATIENTS; PROSTATE; REVIEWS; STANDARD OF LIVING; VALIDATION

Citation Formats

O'Callaghan, Michael E., E-mail: elspeth.raymond@health.sa.gov.au, Freemasons Foundation Centre for Men's Health, University of Adelaide, Urology Unit, Repatriation General Hospital, SA Health, Flinders Centre for Innovation in Cancer, Raymond, Elspeth, Campbell, Jared M., Vincent, Andrew D., Beckmann, Kerri, Centre for Population Health Research, University of South Australia, Roder, David, Evans, Sue, McNeil, John, Millar, Jeremy, Zalcberg, John, Borg, Martin, Adelaide Radiotherapy Centre, Moretti, Kim, Freemasons Foundation Centre for Men's Health, University of Adelaide, Flinders Centre for Innovation in Cancer, Centre for Population Health Research, University of South Australia, and Discipline of Surgery, University of Adelaide. Patient-Reported Outcomes After Radiation Therapy in Men With Prostate Cancer: A Systematic Review of Prognostic Tool Accuracy and Validity. United States: N. p., 2017. Web. doi:10.1016/J.IJROBP.2017.02.024.
O'Callaghan, Michael E., E-mail: elspeth.raymond@health.sa.gov.au, Freemasons Foundation Centre for Men's Health, University of Adelaide, Urology Unit, Repatriation General Hospital, SA Health, Flinders Centre for Innovation in Cancer, Raymond, Elspeth, Campbell, Jared M., Vincent, Andrew D., Beckmann, Kerri, Centre for Population Health Research, University of South Australia, Roder, David, Evans, Sue, McNeil, John, Millar, Jeremy, Zalcberg, John, Borg, Martin, Adelaide Radiotherapy Centre, Moretti, Kim, Freemasons Foundation Centre for Men's Health, University of Adelaide, Flinders Centre for Innovation in Cancer, Centre for Population Health Research, University of South Australia, & Discipline of Surgery, University of Adelaide. Patient-Reported Outcomes After Radiation Therapy in Men With Prostate Cancer: A Systematic Review of Prognostic Tool Accuracy and Validity. United States. doi:10.1016/J.IJROBP.2017.02.024.
O'Callaghan, Michael E., E-mail: elspeth.raymond@health.sa.gov.au, Freemasons Foundation Centre for Men's Health, University of Adelaide, Urology Unit, Repatriation General Hospital, SA Health, Flinders Centre for Innovation in Cancer, Raymond, Elspeth, Campbell, Jared M., Vincent, Andrew D., Beckmann, Kerri, Centre for Population Health Research, University of South Australia, Roder, David, Evans, Sue, McNeil, John, Millar, Jeremy, Zalcberg, John, Borg, Martin, Adelaide Radiotherapy Centre, Moretti, Kim, Freemasons Foundation Centre for Men's Health, University of Adelaide, Flinders Centre for Innovation in Cancer, Centre for Population Health Research, University of South Australia, and Discipline of Surgery, University of Adelaide. Thu . "Patient-Reported Outcomes After Radiation Therapy in Men With Prostate Cancer: A Systematic Review of Prognostic Tool Accuracy and Validity". United States. doi:10.1016/J.IJROBP.2017.02.024.
@article{osti_22649929,
title = {Patient-Reported Outcomes After Radiation Therapy in Men With Prostate Cancer: A Systematic Review of Prognostic Tool Accuracy and Validity},
author = {O'Callaghan, Michael E., E-mail: elspeth.raymond@health.sa.gov.au and Freemasons Foundation Centre for Men's Health, University of Adelaide and Urology Unit, Repatriation General Hospital, SA Health, Flinders Centre for Innovation in Cancer and Raymond, Elspeth and Campbell, Jared M. and Vincent, Andrew D. and Beckmann, Kerri and Centre for Population Health Research, University of South Australia and Roder, David and Evans, Sue and McNeil, John and Millar, Jeremy and Zalcberg, John and Borg, Martin and Adelaide Radiotherapy Centre and Moretti, Kim and Freemasons Foundation Centre for Men's Health, University of Adelaide and Flinders Centre for Innovation in Cancer, Centre for Population Health Research, University of South Australia and Discipline of Surgery, University of Adelaide},
abstractNote = {Purpose: To identify, through a systematic review, all validated tools used for the prediction of patient-reported outcome measures (PROMs) in patients being treated with radiation therapy for prostate cancer, and provide a comparative summary of accuracy and generalizability. Methods and Materials: PubMed and EMBASE were searched from July 2007. Title/abstract screening, full text review, and critical appraisal were undertaken by 2 reviewers, whereas data extraction was performed by a single reviewer. Eligible articles had to provide a summary measure of accuracy and undertake internal or external validation. Tools were recommended for clinical implementation if they had been externally validated and found to have accuracy ≥70%. Results: The search strategy identified 3839 potential studies, of which 236 progressed to full text review and 22 were included. From these studies, 50 tools predicted gastrointestinal/rectal symptoms, 29 tools predicted genitourinary symptoms, 4 tools predicted erectile dysfunction, and no tools predicted quality of life. For patients treated with external beam radiation therapy, 3 tools could be recommended for the prediction of rectal toxicity, gastrointestinal toxicity, and erectile dysfunction. For patients treated with brachytherapy, 2 tools could be recommended for the prediction of urinary retention and erectile dysfunction. Conclusions: A large number of tools for the prediction of PROMs in prostate cancer patients treated with radiation therapy have been developed. Only a small minority are accurate and have been shown to be generalizable through external validation. This review provides an accessible catalogue of tools that are ready for clinical implementation as well as which should be prioritized for validation.},
doi = {10.1016/J.IJROBP.2017.02.024},
journal = {International Journal of Radiation Oncology, Biology and Physics},
number = 2,
volume = 98,
place = {United States},
year = {Thu Jun 01 00:00:00 EDT 2017},
month = {Thu Jun 01 00:00:00 EDT 2017}
}