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Title: Long-Term Results of a Highly Performing Conformal Electron Therapy Technique for Chest Wall Irradiation After Mastectomy

Abstract

Purpose: To evaluate locoregional control and survival after mastectomy, as well as toxicity, in patients irradiated by a previously described postmastectomy highly conformal electron beam radiation therapy technique (PMERT). Methods and Materials: We included all women irradiated by postmastectomy electron beam radiation therapy for nonmetastatic breast cancer between 2007 and 2011 in our department. Acute and late toxicities were retrospectively assessed using Common Terminology Criteria for Adverse Events version 3.0 criteria. Results: Among the 796 women included, 10.1% were triple-negative, 18.8% HER2-positive, and 24.6% received neoadjuvant chemotherapy (CT). Multifocal lesions were observed in 51.3% of women, and 64.6% had at least 1 involved lymph node (LN). Internal mammary chain, supraclavicular, infraclavicular, and axillary LNs were treated in 85.6%, 88.3%, 77.9%, and 14.9% of cases, respectively. With a median follow-up of 64 months (range, 6-102 months), 5-year locoregional recurrence–free survival and overall survival were 90% (95% confidence interval 88.1%-92.4%) and 90.9% (95% confidence interval 88.9%-93%), respectively. Early skin toxicity was scored as grade 1 in 58.5% of patients, grade 2 in 35.9%, and grade 3 in 4.5%. Concomitant CT was associated with increased grade 3 toxicity (P<.001). At long-term follow-up, 29.8% of patients presented temporary or permanent hyperpigmentation or telangiectasia or fibrosis (grade 1:more » 23.6%; grade 2: 5.2%; grade 3: 1%), with higher rates among smokers (P=.06); 274 patients (34.4%) underwent breast reconstruction. Only 24 patients (3%) had early esophagitis of grade 1. Only 3 patients developed ischemic heart disease: all had been treated by anthracycline-based CT with or without trastuzumab, all had been irradiated to the left chest wall and LN, and all presented numerous cardiovascular risk factors (2-4 factors). Conclusions: This study demonstrated the good efficacy of this technique in terms of locoregional control and survival, and good short-term and long-term safety. Longer follow-up is required to analyze chronic cardiac events.« less

Authors:
 [1];  [2]; ; ;  [1];  [2];  [1];  [3];  [4];  [2]; ;  [1]
  1. Department of Radiation Oncology, Institut Curie, Paris (France)
  2. Department of Biostatistics, Institut Curie, Paris (France)
  3. Department of Surgical Oncology, Institut Curie, Paris (France)
  4. Department of Medical Oncology, Institut Curie, Paris (France)
Publication Date:
OSTI Identifier:
22649924
Resource Type:
Journal Article
Resource Relation:
Journal Name: International Journal of Radiation Oncology, Biology and Physics; Journal Volume: 98; Journal Issue: 1; Other Information: Copyright (c) 2017 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; CHEMOTHERAPY; CHEST; ELECTRON BEAMS; IRRADIATION; LYMPH NODES; MAMMARY GLANDS; PATIENTS; RADIATION HAZARDS; RADIOTHERAPY; TOXICITY; WOMEN

Citation Formats

Grellier Adedjouma, Noemie, E-mail: grellier.noemie@gmail.com, Chevrier, Marion, Fourquet, Alain, Costa, Emilie, Xu, Haoping, Berger, Frederique, Campana, Francois, Laki, Fatima, Beuzeboc, Philippe, Lefeuvre, Delphine, Fournier-Bidoz, Nathalie, and Kirova, Youlia M.. Long-Term Results of a Highly Performing Conformal Electron Therapy Technique for Chest Wall Irradiation After Mastectomy. United States: N. p., 2017. Web. doi:10.1016/J.IJROBP.2017.01.205.
Grellier Adedjouma, Noemie, E-mail: grellier.noemie@gmail.com, Chevrier, Marion, Fourquet, Alain, Costa, Emilie, Xu, Haoping, Berger, Frederique, Campana, Francois, Laki, Fatima, Beuzeboc, Philippe, Lefeuvre, Delphine, Fournier-Bidoz, Nathalie, & Kirova, Youlia M.. Long-Term Results of a Highly Performing Conformal Electron Therapy Technique for Chest Wall Irradiation After Mastectomy. United States. doi:10.1016/J.IJROBP.2017.01.205.
Grellier Adedjouma, Noemie, E-mail: grellier.noemie@gmail.com, Chevrier, Marion, Fourquet, Alain, Costa, Emilie, Xu, Haoping, Berger, Frederique, Campana, Francois, Laki, Fatima, Beuzeboc, Philippe, Lefeuvre, Delphine, Fournier-Bidoz, Nathalie, and Kirova, Youlia M.. Mon . "Long-Term Results of a Highly Performing Conformal Electron Therapy Technique for Chest Wall Irradiation After Mastectomy". United States. doi:10.1016/J.IJROBP.2017.01.205.
@article{osti_22649924,
title = {Long-Term Results of a Highly Performing Conformal Electron Therapy Technique for Chest Wall Irradiation After Mastectomy},
author = {Grellier Adedjouma, Noemie, E-mail: grellier.noemie@gmail.com and Chevrier, Marion and Fourquet, Alain and Costa, Emilie and Xu, Haoping and Berger, Frederique and Campana, Francois and Laki, Fatima and Beuzeboc, Philippe and Lefeuvre, Delphine and Fournier-Bidoz, Nathalie and Kirova, Youlia M.},
abstractNote = {Purpose: To evaluate locoregional control and survival after mastectomy, as well as toxicity, in patients irradiated by a previously described postmastectomy highly conformal electron beam radiation therapy technique (PMERT). Methods and Materials: We included all women irradiated by postmastectomy electron beam radiation therapy for nonmetastatic breast cancer between 2007 and 2011 in our department. Acute and late toxicities were retrospectively assessed using Common Terminology Criteria for Adverse Events version 3.0 criteria. Results: Among the 796 women included, 10.1% were triple-negative, 18.8% HER2-positive, and 24.6% received neoadjuvant chemotherapy (CT). Multifocal lesions were observed in 51.3% of women, and 64.6% had at least 1 involved lymph node (LN). Internal mammary chain, supraclavicular, infraclavicular, and axillary LNs were treated in 85.6%, 88.3%, 77.9%, and 14.9% of cases, respectively. With a median follow-up of 64 months (range, 6-102 months), 5-year locoregional recurrence–free survival and overall survival were 90% (95% confidence interval 88.1%-92.4%) and 90.9% (95% confidence interval 88.9%-93%), respectively. Early skin toxicity was scored as grade 1 in 58.5% of patients, grade 2 in 35.9%, and grade 3 in 4.5%. Concomitant CT was associated with increased grade 3 toxicity (P<.001). At long-term follow-up, 29.8% of patients presented temporary or permanent hyperpigmentation or telangiectasia or fibrosis (grade 1: 23.6%; grade 2: 5.2%; grade 3: 1%), with higher rates among smokers (P=.06); 274 patients (34.4%) underwent breast reconstruction. Only 24 patients (3%) had early esophagitis of grade 1. Only 3 patients developed ischemic heart disease: all had been treated by anthracycline-based CT with or without trastuzumab, all had been irradiated to the left chest wall and LN, and all presented numerous cardiovascular risk factors (2-4 factors). Conclusions: This study demonstrated the good efficacy of this technique in terms of locoregional control and survival, and good short-term and long-term safety. Longer follow-up is required to analyze chronic cardiac events.},
doi = {10.1016/J.IJROBP.2017.01.205},
journal = {International Journal of Radiation Oncology, Biology and Physics},
number = 1,
volume = 98,
place = {United States},
year = {Mon May 01 00:00:00 EDT 2017},
month = {Mon May 01 00:00:00 EDT 2017}
}