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Title: Water Exchange Rate Constant as a Biomarker of Treatment Efficacy in Patients With Brain Metastases Undergoing Stereotactic Radiosurgery

Abstract

Purpose: This study was designed to evaluate whether changes in metastatic brain tumors after stereotactic radiosurgery (SRS) can be seen with quantitative MRI early after treatment. Methods and Materials: Using contrast-enhanced MRI, a 3-water-compartment tissue model consisting of intracellular (I), extracellular-extravascular (E), and vascular (V) compartments was used to assess the intra–extracellular water exchange rate constant (k{sub IE}), efflux rate constant (k{sub ep}), and water compartment volume fractions (M{sub 0,I}, M{sub 0,E}, M{sub 0,V}). In this prospective study, 19 patients were MRI-scanned before treatment and 1 week and 1 month after SRS. The change in model parameters between the pretreatment and 1-week posttreatment scans was correlated to the change in tumor volume between pretreatment and 1-month posttreatment scans. Results: At 1 week k{sub IE} differentiated (P<.001) tumors that had partial response from tumors with stable and progressive disease, and a high correlation (R=−0.76, P<.001) was observed between early changes in the k{sub IE} and tumor volume change 1 month after treatment. Other model parameters had lower correlation (M{sub 0,E}) or no correlation (k{sub ep}, M{sub 0,V}). Conclusions: This is the first study that measured k{sub IE} early after SRS, and it found that early changes in k{sub IE} (1 week after treatment) highly correlated with long-termmore » tumor response and could predict the extent of tumor shrinkage at 1 month after SRS.« less

Authors:
 [1];  [2];  [3];  [4];  [5];  [6];  [3];  [2];  [1];  [2];  [2];  [7];  [1];  [2];  [1];  [2];  [8]
  1. Medical Biophysics, University of Toronto, Toronto, Ontario (Canada)
  2. (Canada)
  3. Physical Sciences, Sunnybrook Research Institute, Toronto, Ontario (Canada)
  4. Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ontario (Canada)
  5. Computer Science Department, University College London, London (United Kingdom)
  6. Neurosurgery and Pediatric Neurosurgery, Medical University, Lublin (Poland)
  7. Radiation Oncology, Sunnybrook Health Sciences Centre, Toronto, Ontario (Canada)
  8. (Poland)
Publication Date:
OSTI Identifier:
22649906
Resource Type:
Journal Article
Resource Relation:
Journal Name: International Journal of Radiation Oncology, Biology and Physics; Journal Volume: 98; Journal Issue: 1; Other Information: Copyright (c) 2017 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; BIOLOGICAL MARKERS; BRAIN; CORRELATIONS; FOREIGN EXCHANGE RATE; NEOPLASMS; NMR IMAGING; PATIENTS; RADIOTHERAPY; REACTION KINETICS; SURGERY

Citation Formats

Mehrabian, Hatef, E-mail: hatef.mehrabian@sri.utoronto.ca, Physical Sciences, Sunnybrook Research Institute, Toronto, Ontario, Desmond, Kimberly L., Chavez, Sofia, Bailey, Colleen, Rola, Radoslaw, Sahgal, Arjun, Radiation Oncology, Sunnybrook Health Sciences Centre, Toronto, Ontario, Czarnota, Gregory J., Physical Sciences, Sunnybrook Research Institute, Toronto, Ontario, Radiation Oncology, Sunnybrook Health Sciences Centre, Toronto, Ontario, Soliman, Hany, Martel, Anne L., Physical Sciences, Sunnybrook Research Institute, Toronto, Ontario, Stanisz, Greg J., Physical Sciences, Sunnybrook Research Institute, Toronto, Ontario, and Neurosurgery and Pediatric Neurosurgery, Medical University, Lublin. Water Exchange Rate Constant as a Biomarker of Treatment Efficacy in Patients With Brain Metastases Undergoing Stereotactic Radiosurgery. United States: N. p., 2017. Web. doi:10.1016/J.IJROBP.2017.01.016.
Mehrabian, Hatef, E-mail: hatef.mehrabian@sri.utoronto.ca, Physical Sciences, Sunnybrook Research Institute, Toronto, Ontario, Desmond, Kimberly L., Chavez, Sofia, Bailey, Colleen, Rola, Radoslaw, Sahgal, Arjun, Radiation Oncology, Sunnybrook Health Sciences Centre, Toronto, Ontario, Czarnota, Gregory J., Physical Sciences, Sunnybrook Research Institute, Toronto, Ontario, Radiation Oncology, Sunnybrook Health Sciences Centre, Toronto, Ontario, Soliman, Hany, Martel, Anne L., Physical Sciences, Sunnybrook Research Institute, Toronto, Ontario, Stanisz, Greg J., Physical Sciences, Sunnybrook Research Institute, Toronto, Ontario, & Neurosurgery and Pediatric Neurosurgery, Medical University, Lublin. Water Exchange Rate Constant as a Biomarker of Treatment Efficacy in Patients With Brain Metastases Undergoing Stereotactic Radiosurgery. United States. doi:10.1016/J.IJROBP.2017.01.016.
Mehrabian, Hatef, E-mail: hatef.mehrabian@sri.utoronto.ca, Physical Sciences, Sunnybrook Research Institute, Toronto, Ontario, Desmond, Kimberly L., Chavez, Sofia, Bailey, Colleen, Rola, Radoslaw, Sahgal, Arjun, Radiation Oncology, Sunnybrook Health Sciences Centre, Toronto, Ontario, Czarnota, Gregory J., Physical Sciences, Sunnybrook Research Institute, Toronto, Ontario, Radiation Oncology, Sunnybrook Health Sciences Centre, Toronto, Ontario, Soliman, Hany, Martel, Anne L., Physical Sciences, Sunnybrook Research Institute, Toronto, Ontario, Stanisz, Greg J., Physical Sciences, Sunnybrook Research Institute, Toronto, Ontario, and Neurosurgery and Pediatric Neurosurgery, Medical University, Lublin. Mon . "Water Exchange Rate Constant as a Biomarker of Treatment Efficacy in Patients With Brain Metastases Undergoing Stereotactic Radiosurgery". United States. doi:10.1016/J.IJROBP.2017.01.016.
@article{osti_22649906,
title = {Water Exchange Rate Constant as a Biomarker of Treatment Efficacy in Patients With Brain Metastases Undergoing Stereotactic Radiosurgery},
author = {Mehrabian, Hatef, E-mail: hatef.mehrabian@sri.utoronto.ca and Physical Sciences, Sunnybrook Research Institute, Toronto, Ontario and Desmond, Kimberly L. and Chavez, Sofia and Bailey, Colleen and Rola, Radoslaw and Sahgal, Arjun and Radiation Oncology, Sunnybrook Health Sciences Centre, Toronto, Ontario and Czarnota, Gregory J. and Physical Sciences, Sunnybrook Research Institute, Toronto, Ontario and Radiation Oncology, Sunnybrook Health Sciences Centre, Toronto, Ontario and Soliman, Hany and Martel, Anne L. and Physical Sciences, Sunnybrook Research Institute, Toronto, Ontario and Stanisz, Greg J. and Physical Sciences, Sunnybrook Research Institute, Toronto, Ontario and Neurosurgery and Pediatric Neurosurgery, Medical University, Lublin},
abstractNote = {Purpose: This study was designed to evaluate whether changes in metastatic brain tumors after stereotactic radiosurgery (SRS) can be seen with quantitative MRI early after treatment. Methods and Materials: Using contrast-enhanced MRI, a 3-water-compartment tissue model consisting of intracellular (I), extracellular-extravascular (E), and vascular (V) compartments was used to assess the intra–extracellular water exchange rate constant (k{sub IE}), efflux rate constant (k{sub ep}), and water compartment volume fractions (M{sub 0,I}, M{sub 0,E}, M{sub 0,V}). In this prospective study, 19 patients were MRI-scanned before treatment and 1 week and 1 month after SRS. The change in model parameters between the pretreatment and 1-week posttreatment scans was correlated to the change in tumor volume between pretreatment and 1-month posttreatment scans. Results: At 1 week k{sub IE} differentiated (P<.001) tumors that had partial response from tumors with stable and progressive disease, and a high correlation (R=−0.76, P<.001) was observed between early changes in the k{sub IE} and tumor volume change 1 month after treatment. Other model parameters had lower correlation (M{sub 0,E}) or no correlation (k{sub ep}, M{sub 0,V}). Conclusions: This is the first study that measured k{sub IE} early after SRS, and it found that early changes in k{sub IE} (1 week after treatment) highly correlated with long-term tumor response and could predict the extent of tumor shrinkage at 1 month after SRS.},
doi = {10.1016/J.IJROBP.2017.01.016},
journal = {International Journal of Radiation Oncology, Biology and Physics},
number = 1,
volume = 98,
place = {United States},
year = {Mon May 01 00:00:00 EDT 2017},
month = {Mon May 01 00:00:00 EDT 2017}
}