Radical Cystectomy Compared to Combined Modality Treatment for Muscle-Invasive Bladder Cancer: A Systematic Review and Meta-Analysis

Vashistha, Vishal; Wang, Hanzhang; Mazzone, Andrew; Liss, Michael A.; Svatek, Robert S.; Schleicher, Mary; Kaushik, Dharam

doi:10.1016/J.IJROBP.2016.11.056

Title: Radical Cystectomy Compared to Combined Modality Treatment for Muscle-Invasive Bladder Cancer: A Systematic Review and Meta-Analysis

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Abstract

Purpose: To perform a comprehensive comparison of overall survival (OS), disease-specific survival (DSS), progression-free survival (PFS), and treatment-related complications between radical cystectomy (RC) and combined modality treatment (CMT—radiation therapy, concurrent chemotherapy, and maximal transurethral resection of bladder tumor) in the setting of muscle-invasive bladder cancer. Methods and Materials: We searched 7 databases (PubMed, Scopus, EMBASE, Proquest, CINAHL, and (ClinicalTrials.gov)) for randomized, controlled trials and prospective and retrospective studies directly comparing RC with CMT from database inception to March 2016. We conducted meta-analyses evaluating OS, DSS, and PFS with hazard ratios (HRs) and 95% confidence intervals (CIs). Results: Nineteen studies evaluating 12,380 subjects were selected. For the 8 studies encompassing 9554 subjects eligible for meta-analyses, we found no difference in OS at 5 years (HR 0.96, favoring CMT, 95% CI 0.72-1.29; P=.778) or 10 years (HR 1.02, favoring cystectomy, 95% CI 0.73-1.42; P=.905). No difference was observed in DSS at 5 years (HR 0.83, favoring radiation, 95% CI 0.54-1.28; P=.390) or 10 years (HR 1.17, favoring cystectomy, 95% CI 0.89-1.55; P=.264), or PFS at 10 years (HR 0.85, favoring CMT, 95% CI 0.43-1.67; P=.639). The cystectomy arms had higher rates of early major complications, whereas rates of minor complications were similar between the 2 treatments. Conclusion: Current meta-analysis reveals no differences inmore »« less

Authors:

Vashistha, Vishal ^[1]; Wang, Hanzhang ^[2]; Mazzone, Andrew ^[3]; Liss, Michael A.; Svatek, Robert S. ^[2]; Schleicher, Mary ^[1]; Kaushik, Dharam ^[2]

Department of Internal Medicine, Cleveland Clinic Foundation, Cleveland, Ohio (United States)
Department of Urology, University of Texas Health Science Center at San Antonio, San Antonio, Texas (United States)
Rush Medical College, Rush University Medical Center, Chicago, Illinois (United States)

Publication Date:: Sat Apr 01 00:00:00 EDT 2017

OSTI Identifier:: 22649890

Resource Type:: Journal Article

Journal Name:: International Journal of Radiation Oncology, Biology and Physics

Additional Journal Information:: Journal Volume: 97; Journal Issue: 5; Other Information: Copyright (c) 2016 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0360-3016

Country of Publication:: United States

Language:: English

Subject:: 62 RADIOLOGY AND NUCLEAR MEDICINE; BLADDER; CHEMOTHERAPY; NEOPLASMS; RADICALS; RADIOTHERAPY

Citation Formats


                    Vashistha, Vishal, Wang, Hanzhang, Mazzone, Andrew, Liss, Michael A., Svatek, Robert S., Schleicher, Mary, and Kaushik, Dharam. Radical Cystectomy Compared to Combined Modality Treatment for Muscle-Invasive Bladder Cancer: A Systematic Review and Meta-Analysis.  United States: N. p., 2017. 
        Web.  doi:10.1016/J.IJROBP.2016.11.056.

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                    Vashistha, Vishal, Wang, Hanzhang, Mazzone, Andrew, Liss, Michael A., Svatek, Robert S., Schleicher, Mary, & Kaushik, Dharam. Radical Cystectomy Compared to Combined Modality Treatment for Muscle-Invasive Bladder Cancer: A Systematic Review and Meta-Analysis.  United States.  https://doi.org/10.1016/J.IJROBP.2016.11.056

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                    Vashistha, Vishal, Wang, Hanzhang, Mazzone, Andrew, Liss, Michael A., Svatek, Robert S., Schleicher, Mary, and Kaushik, Dharam. 2017.  
        "Radical Cystectomy Compared to Combined Modality Treatment for Muscle-Invasive Bladder Cancer: A Systematic Review and Meta-Analysis".  United States.  https://doi.org/10.1016/J.IJROBP.2016.11.056.

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@article{osti_22649890,

  title        = {Radical Cystectomy Compared to Combined Modality Treatment for Muscle-Invasive Bladder Cancer: A Systematic Review and Meta-Analysis},

  author       = {Vashistha, Vishal and Wang, Hanzhang and Mazzone, Andrew and Liss, Michael A. and Svatek, Robert S. and Schleicher, Mary and Kaushik, Dharam},

  abstractNote = {Purpose: To perform a comprehensive comparison of overall survival (OS), disease-specific survival (DSS), progression-free survival (PFS), and treatment-related complications between radical cystectomy (RC) and combined modality treatment (CMT—radiation therapy, concurrent chemotherapy, and maximal transurethral resection of bladder tumor) in the setting of muscle-invasive bladder cancer. Methods and Materials: We searched 7 databases (PubMed, Scopus, EMBASE, Proquest, CINAHL, and (ClinicalTrials.gov)) for randomized, controlled trials and prospective and retrospective studies directly comparing RC with CMT from database inception to March 2016. We conducted meta-analyses evaluating OS, DSS, and PFS with hazard ratios (HRs) and 95% confidence intervals (CIs). Results: Nineteen studies evaluating 12,380 subjects were selected. For the 8 studies encompassing 9554 subjects eligible for meta-analyses, we found no difference in OS at 5 years (HR 0.96, favoring CMT, 95% CI 0.72-1.29; P=.778) or 10 years (HR 1.02, favoring cystectomy, 95% CI 0.73-1.42; P=.905). No difference was observed in DSS at 5 years (HR 0.83, favoring radiation, 95% CI 0.54-1.28; P=.390) or 10 years (HR 1.17, favoring cystectomy, 95% CI 0.89-1.55; P=.264), or PFS at 10 years (HR 0.85, favoring CMT, 95% CI 0.43-1.67; P=.639). The cystectomy arms had higher rates of early major complications, whereas rates of minor complications were similar between the 2 treatments. Conclusion: Current meta-analysis reveals no differences in OS, DSS, or PFS between RC and CMT. Further randomized, controlled trials are necessary to identify the optimal treatment for specific patients.},

  doi          = {10.1016/J.IJROBP.2016.11.056},

  url          = {https://www.osti.gov/biblio/22649890},
  journal      = {International Journal of Radiation Oncology, Biology and Physics},

  issn         = {0360-3016},

  number       = 5,

  volume       = 97,

  place        = {United States},

  year         = {Sat Apr 01 00:00:00 EDT 2017},

  month        = {Sat Apr 01 00:00:00 EDT 2017}

}

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