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Title: Is Dose Deformation–Invariance Hypothesis Verified in Prostate IGRT?

Abstract

Purpose: To assess dose uncertainties resulting from the dose deformation–invariance hypothesis in prostate cone beam computed tomography (CT)–based image guided radiation therapy (IGRT), namely to evaluate whether rigidly propagated planned dose distribution enables good estimation of fraction dose distributions. Methods and Materials: Twenty patients underwent a CT scan for planning intensity modulated radiation therapy–IGRT delivering 80 Gy to the prostate, followed by weekly CT scans. Two methods were used to obtain the dose distributions on the weekly CT scans: (1) recalculating the dose using the original treatment plan; and (2) rigidly propagating the planned dose distribution. The cumulative doses were then estimated in the organs at risk for each dose distribution by deformable image registration. The differences between recalculated and propagated doses were finally calculated for the fraction and the cumulative dose distributions, by use of per-voxel and dose-volume histogram (DVH) metrics. Results: For the fraction dose, the mean per-voxel absolute dose difference was <1 Gy for 98% and 95% of the fractions for the rectum and bladder, respectively. The maximum dose difference within 1 voxel reached, however, 7.4 Gy in the bladder and 8.0 Gy in the rectum. The mean dose differences were correlated with gas volume for the rectum and patient external contour variationsmore » for the bladder. The mean absolute differences for the considered volume receiving greater than or equal to dose x (V{sub x}) of the DVH were between 0.37% and 0.70% for the rectum and between 0.53% and 1.22% for the bladder. For the cumulative dose, the mean differences in the DVH were between 0.23% and 1.11% for the rectum and between 0.55% and 1.66% for the bladder. The largest dose difference was 6.86%, for bladder V{sub 80Gy}. The mean dose differences were <1.1 Gy for the rectum and <1 Gy for the bladder. Conclusions: The deformation–invariance hypothesis was corroborated for the organs at risk in prostate IGRT except in cases of a large disappearance or appearance of rectal gas for the rectum and large external contour variations for the bladder.« less

Authors:
 [1];  [2]; ; ;  [1];  [2];  [1];  [2];  [2]; ;  [1];  [2]; ;  [1];  [2];  [2]
  1. INSERM, U1099, 35000 Rennes (France)
  2. (France)
Publication Date:
OSTI Identifier:
22649873
Resource Type:
Journal Article
Resource Relation:
Journal Name: International Journal of Radiation Oncology, Biology and Physics; Journal Volume: 97; Journal Issue: 4; Other Information: Copyright (c) 2016 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; BLADDER; COMPUTERIZED TOMOGRAPHY; GY RANGE 01-10; GY RANGE 10-100; PROSTATE; RADIATION DOSE DISTRIBUTIONS; RADIATION HAZARDS; RADIOTHERAPY; RECTUM

Citation Formats

Simon, Antoine, E-mail: antoine.simon@univ-rennes1.fr, Laboratoire Traitement du Signal et de l'Image, Université de Rennes 1, 35000 Rennes, Le Maitre, Amandine, Nassef, Mohamed, Rigaud, Bastien, Laboratoire Traitement du Signal et de l'Image, Université de Rennes 1, 35000 Rennes, Castelli, Joël, Laboratoire Traitement du Signal et de l'Image, Université de Rennes 1, 35000 Rennes, Department of Radiotherapy, Centre Eugène Marquis, 35000 Rennes, Acosta, Oscar, Haigron, Pascal, Laboratoire Traitement du Signal et de l'Image, Université de Rennes 1, 35000 Rennes, Lafond, Caroline, Crevoisier, Renaud de, Laboratoire Traitement du Signal et de l'Image, Université de Rennes 1, 35000 Rennes, and Department of Radiotherapy, Centre Eugène Marquis, 35000 Rennes. Is Dose Deformation–Invariance Hypothesis Verified in Prostate IGRT?. United States: N. p., 2017. Web. doi:10.1016/J.IJROBP.2016.12.011.
Simon, Antoine, E-mail: antoine.simon@univ-rennes1.fr, Laboratoire Traitement du Signal et de l'Image, Université de Rennes 1, 35000 Rennes, Le Maitre, Amandine, Nassef, Mohamed, Rigaud, Bastien, Laboratoire Traitement du Signal et de l'Image, Université de Rennes 1, 35000 Rennes, Castelli, Joël, Laboratoire Traitement du Signal et de l'Image, Université de Rennes 1, 35000 Rennes, Department of Radiotherapy, Centre Eugène Marquis, 35000 Rennes, Acosta, Oscar, Haigron, Pascal, Laboratoire Traitement du Signal et de l'Image, Université de Rennes 1, 35000 Rennes, Lafond, Caroline, Crevoisier, Renaud de, Laboratoire Traitement du Signal et de l'Image, Université de Rennes 1, 35000 Rennes, & Department of Radiotherapy, Centre Eugène Marquis, 35000 Rennes. Is Dose Deformation–Invariance Hypothesis Verified in Prostate IGRT?. United States. doi:10.1016/J.IJROBP.2016.12.011.
Simon, Antoine, E-mail: antoine.simon@univ-rennes1.fr, Laboratoire Traitement du Signal et de l'Image, Université de Rennes 1, 35000 Rennes, Le Maitre, Amandine, Nassef, Mohamed, Rigaud, Bastien, Laboratoire Traitement du Signal et de l'Image, Université de Rennes 1, 35000 Rennes, Castelli, Joël, Laboratoire Traitement du Signal et de l'Image, Université de Rennes 1, 35000 Rennes, Department of Radiotherapy, Centre Eugène Marquis, 35000 Rennes, Acosta, Oscar, Haigron, Pascal, Laboratoire Traitement du Signal et de l'Image, Université de Rennes 1, 35000 Rennes, Lafond, Caroline, Crevoisier, Renaud de, Laboratoire Traitement du Signal et de l'Image, Université de Rennes 1, 35000 Rennes, and Department of Radiotherapy, Centre Eugène Marquis, 35000 Rennes. Wed . "Is Dose Deformation–Invariance Hypothesis Verified in Prostate IGRT?". United States. doi:10.1016/J.IJROBP.2016.12.011.
@article{osti_22649873,
title = {Is Dose Deformation–Invariance Hypothesis Verified in Prostate IGRT?},
author = {Simon, Antoine, E-mail: antoine.simon@univ-rennes1.fr and Laboratoire Traitement du Signal et de l'Image, Université de Rennes 1, 35000 Rennes and Le Maitre, Amandine and Nassef, Mohamed and Rigaud, Bastien and Laboratoire Traitement du Signal et de l'Image, Université de Rennes 1, 35000 Rennes and Castelli, Joël and Laboratoire Traitement du Signal et de l'Image, Université de Rennes 1, 35000 Rennes and Department of Radiotherapy, Centre Eugène Marquis, 35000 Rennes and Acosta, Oscar and Haigron, Pascal and Laboratoire Traitement du Signal et de l'Image, Université de Rennes 1, 35000 Rennes and Lafond, Caroline and Crevoisier, Renaud de and Laboratoire Traitement du Signal et de l'Image, Université de Rennes 1, 35000 Rennes and Department of Radiotherapy, Centre Eugène Marquis, 35000 Rennes},
abstractNote = {Purpose: To assess dose uncertainties resulting from the dose deformation–invariance hypothesis in prostate cone beam computed tomography (CT)–based image guided radiation therapy (IGRT), namely to evaluate whether rigidly propagated planned dose distribution enables good estimation of fraction dose distributions. Methods and Materials: Twenty patients underwent a CT scan for planning intensity modulated radiation therapy–IGRT delivering 80 Gy to the prostate, followed by weekly CT scans. Two methods were used to obtain the dose distributions on the weekly CT scans: (1) recalculating the dose using the original treatment plan; and (2) rigidly propagating the planned dose distribution. The cumulative doses were then estimated in the organs at risk for each dose distribution by deformable image registration. The differences between recalculated and propagated doses were finally calculated for the fraction and the cumulative dose distributions, by use of per-voxel and dose-volume histogram (DVH) metrics. Results: For the fraction dose, the mean per-voxel absolute dose difference was <1 Gy for 98% and 95% of the fractions for the rectum and bladder, respectively. The maximum dose difference within 1 voxel reached, however, 7.4 Gy in the bladder and 8.0 Gy in the rectum. The mean dose differences were correlated with gas volume for the rectum and patient external contour variations for the bladder. The mean absolute differences for the considered volume receiving greater than or equal to dose x (V{sub x}) of the DVH were between 0.37% and 0.70% for the rectum and between 0.53% and 1.22% for the bladder. For the cumulative dose, the mean differences in the DVH were between 0.23% and 1.11% for the rectum and between 0.55% and 1.66% for the bladder. The largest dose difference was 6.86%, for bladder V{sub 80Gy}. The mean dose differences were <1.1 Gy for the rectum and <1 Gy for the bladder. Conclusions: The deformation–invariance hypothesis was corroborated for the organs at risk in prostate IGRT except in cases of a large disappearance or appearance of rectal gas for the rectum and large external contour variations for the bladder.},
doi = {10.1016/J.IJROBP.2016.12.011},
journal = {International Journal of Radiation Oncology, Biology and Physics},
number = 4,
volume = 97,
place = {United States},
year = {Wed Mar 15 00:00:00 EDT 2017},
month = {Wed Mar 15 00:00:00 EDT 2017}
}