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Title: SU-G-TeP3-09: Proton Minibeam Radiation Therapy Increases Normal Tissue Resistance

Abstract

Purpose: The dose tolerances of normal tissues continue being the main limitation in radiotherapy. To overcome it, we recently proposed a novel concept: proton minibeam radiation therapy (pMBRT) [1]. It allies the physical advantages of protons with the normal tissue preservation observed when irradiated with submillimetric spatially fractionated beams (minibeam radiation therapy) [2]. The dose distributions are such that the tumor receives a homogeneous dose distribution, while normal tissues benefit from the spatial fractionation of the dose. The objective of our work was to implement this promising technique at a clinical center (Proton therapy center in Orsay) in order to evaluate the potential gain in tissue sparing. Methods: Dose distributions were measured by means of gafchromic films and a PTW microdiamond detector (60019). Once the dosimetry was established, the whole brain of 7 weeks old male Fischer 344 rats was irradiated. Half of the animals received conventional seamless proton irradiation (25 Gy in one fraction). The other rats were irradiated with pMBRT (58 Gy peak dose in one fraction). The average dose deposited in the same targeted volume was in both cases 25 Gy. Results: The first complete set of dosimetric data in such small proton field sizes was obtainedmore » [3]. Rats treated with conventional proton irradiation exhibited severe moist desquamation and permanent epilation afterwards. The minibeam group, on the other hand, exhibited no skin damage and no clinical symptoms. MRI imaging and histological analysis are planned at 6 months after irradiation. Conclusion: Our preliminary results indicate that pMBRT leads to an increase in tissue resistance. This can open the door to an efficient treatment of very radioresistant tumours. [1] Prezado et al. Med. Phys. 40, 031712, 1–8 (2013).[2] Prezado et al., Rad. Research. 184, 314-21 (2015). [3] Peucelle et al., Med. Phys. 42 7108-13 (2015).« less

Authors:
; ; ; ;  [1]; ; ; ;  [2];  [3]
  1. CNRS, Orsay, Ile de France (France)
  2. Institut Curie, Orsay, Ile de France (France)
  3. Universite Paris Sud, Orsay, Ile de France (France)
Publication Date:
OSTI Identifier:
22649430
Resource Type:
Journal Article
Resource Relation:
Journal Name: Medical Physics; Journal Volume: 43; Journal Issue: 6; Other Information: (c) 2016 American Association of Physicists in Medicine; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; 61 RADIATION PROTECTION AND DOSIMETRY; ANIMAL TISSUES; BIOMEDICAL RADIOGRAPHY; FRACTIONATION; IRRADIATION; NMR IMAGING; PLANT TISSUES; PROTON BEAMS; RADIATION DOSE DISTRIBUTIONS; RADIATION DOSE UNITS; RADIOTHERAPY; RATS

Citation Formats

Prezado, Y, Gonzalez-Infantes, W, Juchaux, M, Martinez-Rovira, I, Peucelle, C, Heinrich, S, Labiod, D, Nauraye, C, Patriarca, A, and Sebrie, C. SU-G-TeP3-09: Proton Minibeam Radiation Therapy Increases Normal Tissue Resistance. United States: N. p., 2016. Web. doi:10.1118/1.4957089.
Prezado, Y, Gonzalez-Infantes, W, Juchaux, M, Martinez-Rovira, I, Peucelle, C, Heinrich, S, Labiod, D, Nauraye, C, Patriarca, A, & Sebrie, C. SU-G-TeP3-09: Proton Minibeam Radiation Therapy Increases Normal Tissue Resistance. United States. doi:10.1118/1.4957089.
Prezado, Y, Gonzalez-Infantes, W, Juchaux, M, Martinez-Rovira, I, Peucelle, C, Heinrich, S, Labiod, D, Nauraye, C, Patriarca, A, and Sebrie, C. Wed . "SU-G-TeP3-09: Proton Minibeam Radiation Therapy Increases Normal Tissue Resistance". United States. doi:10.1118/1.4957089.
@article{osti_22649430,
title = {SU-G-TeP3-09: Proton Minibeam Radiation Therapy Increases Normal Tissue Resistance},
author = {Prezado, Y and Gonzalez-Infantes, W and Juchaux, M and Martinez-Rovira, I and Peucelle, C and Heinrich, S and Labiod, D and Nauraye, C and Patriarca, A and Sebrie, C},
abstractNote = {Purpose: The dose tolerances of normal tissues continue being the main limitation in radiotherapy. To overcome it, we recently proposed a novel concept: proton minibeam radiation therapy (pMBRT) [1]. It allies the physical advantages of protons with the normal tissue preservation observed when irradiated with submillimetric spatially fractionated beams (minibeam radiation therapy) [2]. The dose distributions are such that the tumor receives a homogeneous dose distribution, while normal tissues benefit from the spatial fractionation of the dose. The objective of our work was to implement this promising technique at a clinical center (Proton therapy center in Orsay) in order to evaluate the potential gain in tissue sparing. Methods: Dose distributions were measured by means of gafchromic films and a PTW microdiamond detector (60019). Once the dosimetry was established, the whole brain of 7 weeks old male Fischer 344 rats was irradiated. Half of the animals received conventional seamless proton irradiation (25 Gy in one fraction). The other rats were irradiated with pMBRT (58 Gy peak dose in one fraction). The average dose deposited in the same targeted volume was in both cases 25 Gy. Results: The first complete set of dosimetric data in such small proton field sizes was obtained [3]. Rats treated with conventional proton irradiation exhibited severe moist desquamation and permanent epilation afterwards. The minibeam group, on the other hand, exhibited no skin damage and no clinical symptoms. MRI imaging and histological analysis are planned at 6 months after irradiation. Conclusion: Our preliminary results indicate that pMBRT leads to an increase in tissue resistance. This can open the door to an efficient treatment of very radioresistant tumours. [1] Prezado et al. Med. Phys. 40, 031712, 1–8 (2013).[2] Prezado et al., Rad. Research. 184, 314-21 (2015). [3] Peucelle et al., Med. Phys. 42 7108-13 (2015).},
doi = {10.1118/1.4957089},
journal = {Medical Physics},
number = 6,
volume = 43,
place = {United States},
year = {Wed Jun 15 00:00:00 EDT 2016},
month = {Wed Jun 15 00:00:00 EDT 2016}
}