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Title: SU-F-T-682: In-Vivo Simulation of the Relative Biological Effectiveness in Proton Therapy Using a Monte Carlo Method

Abstract

Purpose: In proton therapy, the relative biological effectiveness (RBE) – compared with conventional photon therapy – is routinely set to 1.1. However, experimental in vitro studies indicate evidence for the variability of the RBE. To clarify the impact on patient treatment, investigation of the RBE in a preclinical case study should be performed. Methods: The Monte Carlo software TOPAS was used to simulate the radiation field of an irradiation setup at the experimental beamline of the proton therapy facility (OncoRay) in Dresden, Germany. Simulations were performed on cone beam CT-data (CBCT) of a xenogeneous mouse with an orthotopic lung carcinoma obtained by an in-house developed small animal image-guided radiotherapy device. A homogeneous physical fraction dose of 1.8Gy was prescribed for the contoured tumor volume. Simulated dose and linear energy transfer distributions were used to estimate RBE values in the mouse based on an RBE model by Wedenberg et al. To characterize radiation sensitivity of normal and tumor tissue, α/β-ratios were taken from the literature for NB1RGB (10.1Gy) and human squamous lung cancer (6.2Gy) cell lines, respectively. Results: Good dose coverage of the target volume was achieved with a spread-out Bragg peak (SOBP). The contra-lateral lung was completely spared from receivingmore » radiation. An increase in RBE towards the distal end of the SOBP from 1.07 to 1.35 and from 1.05 to 1.3 was observed when considering normal tissue and tumor, respectively, with the highest RBE values located distal to the target volume. Conclusion: Modeled RBE values simulated on CBCT for experimental preclinical proton therapy varied with tissue type and depth in a mouse and differed therefore from a constant value of 1.1. Further translational work will include, first, conducting preclinical experiments and, second, analogous RBE studies in patients using experimentally verified simulation settings for our clinically used patient-specific beam conforming technique.« less

Authors:
 [1];  [2]; ;  [1];  [1];  [2];  [1];  [2];  [3];  [1];  [4];  [5]
  1. OncoRay - National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universitaet Dresden (Germany)
  2. (Germany)
  3. Massachusetts General Hospital, Boston, MA (United States)
  4. (DKTK), Dresden (Germany)
  5. (DKFZ), Heidelberg (Germany)
Publication Date:
OSTI Identifier:
22649237
Resource Type:
Journal Article
Resource Relation:
Journal Name: Medical Physics; Journal Volume: 43; Journal Issue: 6; Other Information: (c) 2016 American Association of Physicists in Medicine; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; 61 RADIATION PROTECTION AND DOSIMETRY; ANIMAL TISSUES; COMPUTER CODES; COMPUTERIZED TOMOGRAPHY; IN VIVO; LUNGS; MICE; MONTE CARLO METHOD; PLANT TISSUES; PROTON BEAMS; RADIATION DOSES; RADIOTHERAPY; RBE; SIMULATION

Citation Formats

Oesten, H, Massachusetts General Hospital, Boston, MA, Loeck, S, Wohlfahrt, P, Helmbrecht, S, Institute of Radiation Physics, Helmholtz-Zentrum Dresden-Rossendorf, Tillner, F, Department of Radiation Oncology, University Hospital Carl Gustav Carus, Technische Universitaet Dresden, Schuemann, J, Luehr, A, German Cancer Consortium, and German Cancer Research Center. SU-F-T-682: In-Vivo Simulation of the Relative Biological Effectiveness in Proton Therapy Using a Monte Carlo Method. United States: N. p., 2016. Web. doi:10.1118/1.4956868.
Oesten, H, Massachusetts General Hospital, Boston, MA, Loeck, S, Wohlfahrt, P, Helmbrecht, S, Institute of Radiation Physics, Helmholtz-Zentrum Dresden-Rossendorf, Tillner, F, Department of Radiation Oncology, University Hospital Carl Gustav Carus, Technische Universitaet Dresden, Schuemann, J, Luehr, A, German Cancer Consortium, & German Cancer Research Center. SU-F-T-682: In-Vivo Simulation of the Relative Biological Effectiveness in Proton Therapy Using a Monte Carlo Method. United States. doi:10.1118/1.4956868.
Oesten, H, Massachusetts General Hospital, Boston, MA, Loeck, S, Wohlfahrt, P, Helmbrecht, S, Institute of Radiation Physics, Helmholtz-Zentrum Dresden-Rossendorf, Tillner, F, Department of Radiation Oncology, University Hospital Carl Gustav Carus, Technische Universitaet Dresden, Schuemann, J, Luehr, A, German Cancer Consortium, and German Cancer Research Center. Wed . "SU-F-T-682: In-Vivo Simulation of the Relative Biological Effectiveness in Proton Therapy Using a Monte Carlo Method". United States. doi:10.1118/1.4956868.
@article{osti_22649237,
title = {SU-F-T-682: In-Vivo Simulation of the Relative Biological Effectiveness in Proton Therapy Using a Monte Carlo Method},
author = {Oesten, H and Massachusetts General Hospital, Boston, MA and Loeck, S and Wohlfahrt, P and Helmbrecht, S and Institute of Radiation Physics, Helmholtz-Zentrum Dresden-Rossendorf and Tillner, F and Department of Radiation Oncology, University Hospital Carl Gustav Carus, Technische Universitaet Dresden and Schuemann, J and Luehr, A and German Cancer Consortium and German Cancer Research Center},
abstractNote = {Purpose: In proton therapy, the relative biological effectiveness (RBE) – compared with conventional photon therapy – is routinely set to 1.1. However, experimental in vitro studies indicate evidence for the variability of the RBE. To clarify the impact on patient treatment, investigation of the RBE in a preclinical case study should be performed. Methods: The Monte Carlo software TOPAS was used to simulate the radiation field of an irradiation setup at the experimental beamline of the proton therapy facility (OncoRay) in Dresden, Germany. Simulations were performed on cone beam CT-data (CBCT) of a xenogeneous mouse with an orthotopic lung carcinoma obtained by an in-house developed small animal image-guided radiotherapy device. A homogeneous physical fraction dose of 1.8Gy was prescribed for the contoured tumor volume. Simulated dose and linear energy transfer distributions were used to estimate RBE values in the mouse based on an RBE model by Wedenberg et al. To characterize radiation sensitivity of normal and tumor tissue, α/β-ratios were taken from the literature for NB1RGB (10.1Gy) and human squamous lung cancer (6.2Gy) cell lines, respectively. Results: Good dose coverage of the target volume was achieved with a spread-out Bragg peak (SOBP). The contra-lateral lung was completely spared from receiving radiation. An increase in RBE towards the distal end of the SOBP from 1.07 to 1.35 and from 1.05 to 1.3 was observed when considering normal tissue and tumor, respectively, with the highest RBE values located distal to the target volume. Conclusion: Modeled RBE values simulated on CBCT for experimental preclinical proton therapy varied with tissue type and depth in a mouse and differed therefore from a constant value of 1.1. Further translational work will include, first, conducting preclinical experiments and, second, analogous RBE studies in patients using experimentally verified simulation settings for our clinically used patient-specific beam conforming technique.},
doi = {10.1118/1.4956868},
journal = {Medical Physics},
number = 6,
volume = 43,
place = {United States},
year = {Wed Jun 15 00:00:00 EDT 2016},
month = {Wed Jun 15 00:00:00 EDT 2016}
}