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Title: Decline of Tumor Vascular Function as Assessed by Dynamic Contrast-Enhanced Magnetic Resonance Imaging Is Associated With Poor Responses to Radiation Therapy and Chemotherapy

Abstract

Purpose: To investigate whether changes in the volume transfer coefficient (K{sup trans}) in a growing tumor could be used as a surrogate marker for predicting tumor responses to radiation therapy (RT) and chemotherapy (CT). Methods and Materials: Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) was consecutively performed on tumor-bearing mice, and temporal and spatial changes of K{sup trans} values were measured along with tumor growth. Tumor responses to RT and CT were studied before and after observed changes in K{sup trans} values with time. Results: Dynamic changes with an initial increase and subsequent decline in K{sup trans} values were found to be associated with tumor growth. When each tumor was divided into core and peripheral regions, the K{sup trans} decline was greater in core, although neither vascular structure or necrosis could be linked to this spatial difference. Tumor responses to RT were worse if applied after the decline of K{sup trans}, and there was less drug distribution and cell death in the tumor core after CT. Conclusion: The K{sup trans} value in growing tumors, reflecting the changes of tumor microenvironment and vascular function, is strongly associated with tumor responses to RT and CT and could be a potential surrogate marker formore » predicting the tumor response to these treatments.« less

Authors:
;  [1];  [2];  [2];  [3];  [4];  [5];  [2];  [6];  [4];  [1];  [2];  [2]
  1. Department of Medical Imaging and Radiological Sciences, Chang Gung University, Taoyuan, Taiwan (China)
  2. (China)
  3. Department of Imaging Physics, Division of Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States)
  4. Department of Biomedical Engineering and Environmental Sciences, National TsingHua University, Hsinchu, Taiwan (China)
  5. Radiation Biology Research Center, Institute for Radiological Research, Chang Gung University/Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan (China)
  6. Institute of Biomedical Sciences, Academic Sinica, Taipei, Taiwan (China)
Publication Date:
OSTI Identifier:
22648769
Resource Type:
Journal Article
Resource Relation:
Journal Name: International Journal of Radiation Oncology, Biology and Physics; Journal Volume: 95; Journal Issue: 5; Other Information: Copyright (c) 2016 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; CHEMOTHERAPY; EVALUATION; NEOPLASMS; NMR IMAGING; RADIOTHERAPY

Citation Formats

Chen, Fang-Hsin, Wang, Chun-Chieh, Radiation Biology Research Center, Institute for Radiological Research, Chang Gung University/Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan, Department of Radiation Oncology, Chang Gung Memorial Hospital-LinKou, Taoyuan, Taiwan, Liu, Ho-Ling, Fu, Sheng-Yung, Yu, Ching-Fang, Department of Radiation Oncology, Chang Gung Memorial Hospital-LinKou, Taoyuan, Taiwan, Chang, Chen, Chiang, Chi-Shiun, Hong, Ji-Hong, E-mail: jihong@adm.cgmh.org.tw, Radiation Biology Research Center, Institute for Radiological Research, Chang Gung University/Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan, and Department of Radiation Oncology, Chang Gung Memorial Hospital-LinKou, Taoyuan, Taiwan. Decline of Tumor Vascular Function as Assessed by Dynamic Contrast-Enhanced Magnetic Resonance Imaging Is Associated With Poor Responses to Radiation Therapy and Chemotherapy. United States: N. p., 2016. Web. doi:10.1016/J.IJROBP.2016.03.051.
Chen, Fang-Hsin, Wang, Chun-Chieh, Radiation Biology Research Center, Institute for Radiological Research, Chang Gung University/Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan, Department of Radiation Oncology, Chang Gung Memorial Hospital-LinKou, Taoyuan, Taiwan, Liu, Ho-Ling, Fu, Sheng-Yung, Yu, Ching-Fang, Department of Radiation Oncology, Chang Gung Memorial Hospital-LinKou, Taoyuan, Taiwan, Chang, Chen, Chiang, Chi-Shiun, Hong, Ji-Hong, E-mail: jihong@adm.cgmh.org.tw, Radiation Biology Research Center, Institute for Radiological Research, Chang Gung University/Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan, & Department of Radiation Oncology, Chang Gung Memorial Hospital-LinKou, Taoyuan, Taiwan. Decline of Tumor Vascular Function as Assessed by Dynamic Contrast-Enhanced Magnetic Resonance Imaging Is Associated With Poor Responses to Radiation Therapy and Chemotherapy. United States. doi:10.1016/J.IJROBP.2016.03.051.
Chen, Fang-Hsin, Wang, Chun-Chieh, Radiation Biology Research Center, Institute for Radiological Research, Chang Gung University/Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan, Department of Radiation Oncology, Chang Gung Memorial Hospital-LinKou, Taoyuan, Taiwan, Liu, Ho-Ling, Fu, Sheng-Yung, Yu, Ching-Fang, Department of Radiation Oncology, Chang Gung Memorial Hospital-LinKou, Taoyuan, Taiwan, Chang, Chen, Chiang, Chi-Shiun, Hong, Ji-Hong, E-mail: jihong@adm.cgmh.org.tw, Radiation Biology Research Center, Institute for Radiological Research, Chang Gung University/Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan, and Department of Radiation Oncology, Chang Gung Memorial Hospital-LinKou, Taoyuan, Taiwan. Mon . "Decline of Tumor Vascular Function as Assessed by Dynamic Contrast-Enhanced Magnetic Resonance Imaging Is Associated With Poor Responses to Radiation Therapy and Chemotherapy". United States. doi:10.1016/J.IJROBP.2016.03.051.
@article{osti_22648769,
title = {Decline of Tumor Vascular Function as Assessed by Dynamic Contrast-Enhanced Magnetic Resonance Imaging Is Associated With Poor Responses to Radiation Therapy and Chemotherapy},
author = {Chen, Fang-Hsin and Wang, Chun-Chieh and Radiation Biology Research Center, Institute for Radiological Research, Chang Gung University/Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan and Department of Radiation Oncology, Chang Gung Memorial Hospital-LinKou, Taoyuan, Taiwan and Liu, Ho-Ling and Fu, Sheng-Yung and Yu, Ching-Fang and Department of Radiation Oncology, Chang Gung Memorial Hospital-LinKou, Taoyuan, Taiwan and Chang, Chen and Chiang, Chi-Shiun and Hong, Ji-Hong, E-mail: jihong@adm.cgmh.org.tw and Radiation Biology Research Center, Institute for Radiological Research, Chang Gung University/Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan and Department of Radiation Oncology, Chang Gung Memorial Hospital-LinKou, Taoyuan, Taiwan},
abstractNote = {Purpose: To investigate whether changes in the volume transfer coefficient (K{sup trans}) in a growing tumor could be used as a surrogate marker for predicting tumor responses to radiation therapy (RT) and chemotherapy (CT). Methods and Materials: Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) was consecutively performed on tumor-bearing mice, and temporal and spatial changes of K{sup trans} values were measured along with tumor growth. Tumor responses to RT and CT were studied before and after observed changes in K{sup trans} values with time. Results: Dynamic changes with an initial increase and subsequent decline in K{sup trans} values were found to be associated with tumor growth. When each tumor was divided into core and peripheral regions, the K{sup trans} decline was greater in core, although neither vascular structure or necrosis could be linked to this spatial difference. Tumor responses to RT were worse if applied after the decline of K{sup trans}, and there was less drug distribution and cell death in the tumor core after CT. Conclusion: The K{sup trans} value in growing tumors, reflecting the changes of tumor microenvironment and vascular function, is strongly associated with tumor responses to RT and CT and could be a potential surrogate marker for predicting the tumor response to these treatments.},
doi = {10.1016/J.IJROBP.2016.03.051},
journal = {International Journal of Radiation Oncology, Biology and Physics},
number = 5,
volume = 95,
place = {United States},
year = {Mon Aug 01 00:00:00 EDT 2016},
month = {Mon Aug 01 00:00:00 EDT 2016}
}