skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Disparities in the Use of Postmastectomy Radiation Therapy for Inflammatory Breast Cancer

Abstract

Purpose: Although radiation therapy improves locoregional control and survival for inflammatory breast cancer (IBC), it is underused in this population. The purpose of this study was to identify variables associated with the underuse of postmastectomy radiation therapy (PMRT) for IBC. Methods and Materials: Using the 1998 to 2011 National Cancer Data Base, we identified 8273 women who underwent mastectomy for nonmetastatic IBC. We used logistic regression modeling to determine the demographic, tumor, and treatment variables associated with the underuse of PMRT. Results: Although the use of PMRT increased over time, a total of 30.3% of our cohort did not receive PMRT. On multivariate analysis, variables associated with the underuse of PMRT for IBC included the following (all P<.05): Medicare insurance (odds ratio [OR] = 0.70), annual income <$34,999 (<$30,000: OR=0.79; $30,000-$34,999: OR=0.82), cN2 and cN0 disease (cN2: OR=0.71; cN0: OR=0.63), failure to receive chemotherapy and hormone therapy (chemotherapy: OR=0.15; hormone therapy: OR=0.35), treatment at lower-volume centers (OR=0.83), and treatment in the South and West (South: OR=0.73; West: OR=0.80). Greater distance between patient's residence and radiation facility was also associated with the underuse of PMRT (P=.0001). Conclusions: Although the use of PMRT for IBC has increased over time, it continues to be underused.more » Disparities related to a variety of variables impact which IBC patients receive PMRT. A concerted effort must be made to address these disparities in order to optimize the outcomes for IBC.« less

Authors:
 [1]; ; ; ; ;  [2]; ; ;  [2];  [3];  [2];  [3]
  1. MD Anderson Cancer Center at Cooper, Camden, New Jersey (United States)
  2. University of Texas, MD Anderson Cancer Center, Houston, Texas (United States)
  3. (United States)
Publication Date:
OSTI Identifier:
22648738
Resource Type:
Journal Article
Journal Name:
International Journal of Radiation Oncology, Biology and Physics
Additional Journal Information:
Journal Volume: 95; Journal Issue: 4; Other Information: Copyright (c) 2016 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0360-3016
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; CHEMOTHERAPY; INFLAMMATION; MAMMARY GLANDS; MULTIVARIATE ANALYSIS; NEOPLASMS; RADIOTHERAPY

Citation Formats

Loveland-Jones, Catherine, Lin, Heather, Shen, Yu, Bedrosian, Isabelle, Shaitelman, Simona, Kuerer, Henry, Woodward, Wendy, Ueno, Naoto, Valero, Vicente, MD Anderson Morgan Welch Inflammatory Breast Cancer Research Program and Clinic, Houston, Texas, Babiera, Gildy, E-mail: gvbabiera@mdanderson.org, and MD Anderson Morgan Welch Inflammatory Breast Cancer Research Program and Clinic, Houston, Texas. Disparities in the Use of Postmastectomy Radiation Therapy for Inflammatory Breast Cancer. United States: N. p., 2016. Web. doi:10.1016/J.IJROBP.2016.02.065.
Loveland-Jones, Catherine, Lin, Heather, Shen, Yu, Bedrosian, Isabelle, Shaitelman, Simona, Kuerer, Henry, Woodward, Wendy, Ueno, Naoto, Valero, Vicente, MD Anderson Morgan Welch Inflammatory Breast Cancer Research Program and Clinic, Houston, Texas, Babiera, Gildy, E-mail: gvbabiera@mdanderson.org, & MD Anderson Morgan Welch Inflammatory Breast Cancer Research Program and Clinic, Houston, Texas. Disparities in the Use of Postmastectomy Radiation Therapy for Inflammatory Breast Cancer. United States. doi:10.1016/J.IJROBP.2016.02.065.
Loveland-Jones, Catherine, Lin, Heather, Shen, Yu, Bedrosian, Isabelle, Shaitelman, Simona, Kuerer, Henry, Woodward, Wendy, Ueno, Naoto, Valero, Vicente, MD Anderson Morgan Welch Inflammatory Breast Cancer Research Program and Clinic, Houston, Texas, Babiera, Gildy, E-mail: gvbabiera@mdanderson.org, and MD Anderson Morgan Welch Inflammatory Breast Cancer Research Program and Clinic, Houston, Texas. Fri . "Disparities in the Use of Postmastectomy Radiation Therapy for Inflammatory Breast Cancer". United States. doi:10.1016/J.IJROBP.2016.02.065.
@article{osti_22648738,
title = {Disparities in the Use of Postmastectomy Radiation Therapy for Inflammatory Breast Cancer},
author = {Loveland-Jones, Catherine and Lin, Heather and Shen, Yu and Bedrosian, Isabelle and Shaitelman, Simona and Kuerer, Henry and Woodward, Wendy and Ueno, Naoto and Valero, Vicente and MD Anderson Morgan Welch Inflammatory Breast Cancer Research Program and Clinic, Houston, Texas and Babiera, Gildy, E-mail: gvbabiera@mdanderson.org and MD Anderson Morgan Welch Inflammatory Breast Cancer Research Program and Clinic, Houston, Texas},
abstractNote = {Purpose: Although radiation therapy improves locoregional control and survival for inflammatory breast cancer (IBC), it is underused in this population. The purpose of this study was to identify variables associated with the underuse of postmastectomy radiation therapy (PMRT) for IBC. Methods and Materials: Using the 1998 to 2011 National Cancer Data Base, we identified 8273 women who underwent mastectomy for nonmetastatic IBC. We used logistic regression modeling to determine the demographic, tumor, and treatment variables associated with the underuse of PMRT. Results: Although the use of PMRT increased over time, a total of 30.3% of our cohort did not receive PMRT. On multivariate analysis, variables associated with the underuse of PMRT for IBC included the following (all P<.05): Medicare insurance (odds ratio [OR] = 0.70), annual income <$34,999 (<$30,000: OR=0.79; $30,000-$34,999: OR=0.82), cN2 and cN0 disease (cN2: OR=0.71; cN0: OR=0.63), failure to receive chemotherapy and hormone therapy (chemotherapy: OR=0.15; hormone therapy: OR=0.35), treatment at lower-volume centers (OR=0.83), and treatment in the South and West (South: OR=0.73; West: OR=0.80). Greater distance between patient's residence and radiation facility was also associated with the underuse of PMRT (P=.0001). Conclusions: Although the use of PMRT for IBC has increased over time, it continues to be underused. Disparities related to a variety of variables impact which IBC patients receive PMRT. A concerted effort must be made to address these disparities in order to optimize the outcomes for IBC.},
doi = {10.1016/J.IJROBP.2016.02.065},
journal = {International Journal of Radiation Oncology, Biology and Physics},
issn = {0360-3016},
number = 4,
volume = 95,
place = {United States},
year = {2016},
month = {7}
}