Consensus Recommendations for Radiation Therapy Contouring and Treatment of Vulvar Carcinoma
- Department of Radiation Oncology and Cancer Imaging, Peter MacCallum Cancer Centre and Epworth Radiation Oncology, Melbourne, Victoria (Australia)
- Department of Radiation Oncology, Dana-Farber/Brigham and Women's Cancer Center, Harvard Medical School, Boston, Massachusetts (United States)
- Department of Radiation Oncology, Centre hospitalier de l'universite de Montreal, Montreal, Quebec (Canada)
- Department of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania (United States)
- Department of Radiation Oncology, MD Anderson Cancer Center, Houston, Texas (United States)
- Department of Radiation Oncology, Proedtert and Medical College Clinical Cancer Center, Milwaukee, Wisconsin (United States)
- Department of Radiation Oncology, Princess Margaret Cancer Centre, Toronto, Ontario (Canada)
- Department of Radiation Oncology, British Columbia Cancer Agency, Victoria, British Columbia (Canada)
- Department of Radiation Oncology, Stritch School of Medicine, Loyola University, Maywood, Illinois (United States)
- Department of Radiation Oncology, University of Washington, Seattle, Washington (United States)
- Liverpool Cancer Therapy Centre, Radiation Oncology Unit, Sydney, New South Wales (Australia)
- Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota (United States)
- Radiation Oncology Department, Miller School of Medicine, University of Miami, Miami, Florida (United States)
Purpose: The purpose of this study was to develop a radiation therapy (RT) contouring atlas and recommendations for women with postoperative and locally advanced vulvar carcinoma. Methods and Materials: An international committee of 35 expert gynecologic radiation oncologists completed a survey of the treatment of vulvar carcinoma. An initial set of recommendations for contouring was discussed and generated by consensus. Two cases, 1 locally advanced and 1 postoperative, were contoured by 14 physicians. Contours were compared and analyzed using an expectation-maximization algorithm for simultaneous truth and performance level estimation (STAPLE), and a 95% confidence interval contour was developed. The level of agreement among contours was assessed using a kappa statistic. STAPLE contours underwent full committee editing to generate the final atlas consensus contours. Results: Analysis of the 14 contours showed substantial agreement, with kappa statistics of 0.69 and 0.64 for cases 1 and 2, respectively. There was high specificity for both cases (≥99%) and only moderate sensitivity of 71.3% and 64.9% for cases 1 and 2, respectively. Expert review and discussion generated consensus recommendations for contouring target volumes and treatment for postoperative and locally advanced vulvar cancer. Conclusions: These consensus recommendations for contouring and treatment of vulvar cancer identified areas of complexity and controversy. Given the lack of clinical research evidence in vulvar cancer radiation therapy, the committee advocates a conservative and consistent approach using standardized recommendations.
- OSTI ID:
- 22648735
- Journal Information:
- International Journal of Radiation Oncology, Biology and Physics, Vol. 95, Issue 4; Other Information: Copyright (c) 2016 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); ISSN 0360-3016
- Country of Publication:
- United States
- Language:
- English
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