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Title: Dosimetric and Clinical Outcomes With Intensity Modulated Radiation Therapy After Chemotherapy for Patients With Early-Stage Diffuse Large B-cell Lymphoma of Waldeyer Ring

Abstract

Purpose: To assess the dosimetric benefit, prognosis, and toxicity of intensity modulated radiation therapy (IMRT) for early-stage, diffuse large B-cell lymphoma of Waldeyer ring (WR-DLBCL). Methods and Materials: Sixty-one patients with early-stage WR-DLBCL who received chemotherapy followed by IMRT were retrospectively reviewed. Dosimetric parameters for the target volume and critical normal structures were evaluated, and survival was calculated. Linear regression analysis was used to assess the effect of the mean dose (D{sub mean}) to the parotid glands on xerostomia. Results: The median conformity index and homogeneity index of the planning target volume (PTV) were 0.83 and 0.90, respectively, demonstrating very good coverage of the target volume. The mean dose to the parotid glands was 24.9 Gy. The 5-year overall survival (OS), progression-free survival (PFS), and locoregional control (LRC) were 94.7%, 93.1%, and 98.3%, respectively. Early and late toxicities were mild, and no patient experienced late grade ≥3 toxicities. The D{sub mean} to the parotid glands had a linear correlation with late grade ≥2 xerostomia. Conclusions: IMRT after chemotherapy can provide excellent dose conformity and achieve favorable survival and LRC with mild toxicities in patients with early-stage WR-DLBCL. Dose constraints for the parotid glands should be limited to <24 Gy for early-stage WR-DLBCL.

Authors:
; ; ; ; ; ; ; ;  [1]; ;  [2]; ; ; ; ; ;  [1];  [1]
  1. Department of Radiation Oncology, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing (China)
  2. Department of Medical Oncology, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing (China)
Publication Date:
OSTI Identifier:
22645655
Resource Type:
Journal Article
Resource Relation:
Journal Name: International Journal of Radiation Oncology, Biology and Physics; Journal Volume: 96; Journal Issue: 2; Other Information: Copyright (c) 2016 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; CHEMOTHERAPY; DOSIMETRY; GLANDS; GY RANGE 10-100; LYMPHOMAS; PATIENTS; RADIATION DOSES; RADIOTHERAPY; REGRESSION ANALYSIS; TOXICITY

Citation Formats

Xu, Yong-Gang, Qi, Shu-Nan, Wang, Shu-Lian, Liu, Yue-Ping, Wang, Wei-Hu, Jin, Jing, Song, Yong-Wen, Ren, Hua, Fang, Hui, He, Xiao-Hui, Dong, Mei, Chen, Bo, Lu, Ning-Ning, Li, Ning, Tang, Yuan, Tang, Yu, Dai, Jian-Rong, and Li, Ye-Xiong, E-mail: yexiong12@163.com. Dosimetric and Clinical Outcomes With Intensity Modulated Radiation Therapy After Chemotherapy for Patients With Early-Stage Diffuse Large B-cell Lymphoma of Waldeyer Ring. United States: N. p., 2016. Web. doi:10.1016/J.IJROBP.2016.05.023.
Xu, Yong-Gang, Qi, Shu-Nan, Wang, Shu-Lian, Liu, Yue-Ping, Wang, Wei-Hu, Jin, Jing, Song, Yong-Wen, Ren, Hua, Fang, Hui, He, Xiao-Hui, Dong, Mei, Chen, Bo, Lu, Ning-Ning, Li, Ning, Tang, Yuan, Tang, Yu, Dai, Jian-Rong, & Li, Ye-Xiong, E-mail: yexiong12@163.com. Dosimetric and Clinical Outcomes With Intensity Modulated Radiation Therapy After Chemotherapy for Patients With Early-Stage Diffuse Large B-cell Lymphoma of Waldeyer Ring. United States. doi:10.1016/J.IJROBP.2016.05.023.
Xu, Yong-Gang, Qi, Shu-Nan, Wang, Shu-Lian, Liu, Yue-Ping, Wang, Wei-Hu, Jin, Jing, Song, Yong-Wen, Ren, Hua, Fang, Hui, He, Xiao-Hui, Dong, Mei, Chen, Bo, Lu, Ning-Ning, Li, Ning, Tang, Yuan, Tang, Yu, Dai, Jian-Rong, and Li, Ye-Xiong, E-mail: yexiong12@163.com. Sat . "Dosimetric and Clinical Outcomes With Intensity Modulated Radiation Therapy After Chemotherapy for Patients With Early-Stage Diffuse Large B-cell Lymphoma of Waldeyer Ring". United States. doi:10.1016/J.IJROBP.2016.05.023.
@article{osti_22645655,
title = {Dosimetric and Clinical Outcomes With Intensity Modulated Radiation Therapy After Chemotherapy for Patients With Early-Stage Diffuse Large B-cell Lymphoma of Waldeyer Ring},
author = {Xu, Yong-Gang and Qi, Shu-Nan and Wang, Shu-Lian and Liu, Yue-Ping and Wang, Wei-Hu and Jin, Jing and Song, Yong-Wen and Ren, Hua and Fang, Hui and He, Xiao-Hui and Dong, Mei and Chen, Bo and Lu, Ning-Ning and Li, Ning and Tang, Yuan and Tang, Yu and Dai, Jian-Rong and Li, Ye-Xiong, E-mail: yexiong12@163.com},
abstractNote = {Purpose: To assess the dosimetric benefit, prognosis, and toxicity of intensity modulated radiation therapy (IMRT) for early-stage, diffuse large B-cell lymphoma of Waldeyer ring (WR-DLBCL). Methods and Materials: Sixty-one patients with early-stage WR-DLBCL who received chemotherapy followed by IMRT were retrospectively reviewed. Dosimetric parameters for the target volume and critical normal structures were evaluated, and survival was calculated. Linear regression analysis was used to assess the effect of the mean dose (D{sub mean}) to the parotid glands on xerostomia. Results: The median conformity index and homogeneity index of the planning target volume (PTV) were 0.83 and 0.90, respectively, demonstrating very good coverage of the target volume. The mean dose to the parotid glands was 24.9 Gy. The 5-year overall survival (OS), progression-free survival (PFS), and locoregional control (LRC) were 94.7%, 93.1%, and 98.3%, respectively. Early and late toxicities were mild, and no patient experienced late grade ≥3 toxicities. The D{sub mean} to the parotid glands had a linear correlation with late grade ≥2 xerostomia. Conclusions: IMRT after chemotherapy can provide excellent dose conformity and achieve favorable survival and LRC with mild toxicities in patients with early-stage WR-DLBCL. Dose constraints for the parotid glands should be limited to <24 Gy for early-stage WR-DLBCL.},
doi = {10.1016/J.IJROBP.2016.05.023},
journal = {International Journal of Radiation Oncology, Biology and Physics},
number = 2,
volume = 96,
place = {United States},
year = {Sat Oct 01 00:00:00 EDT 2016},
month = {Sat Oct 01 00:00:00 EDT 2016}
}