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Title: Ga-68 DOTATOC PET/CT-Guided Biopsy and Cryoablation with Autoradiography of Biopsy Specimen for Treatment of Tumor-Induced Osteomalacia

Abstract

Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome caused by small benign tumors of mesenchymal origin also known as phosphaturic mesenchymal tumors mixed connective tissue variant. Excellent prognosis is expected with eradication of the culprit tumor. These small tumors are notoriously difficult to localize with conventional imaging studies; this often leads to an extensive work up and prolonged morbidity. We report a patient with clinical diagnosis of TIO whose culprit tumor was localized with Ga-68 DOTATOC PET/CT and MRI. Biopsy and cryoablation were performed under Ga-68 DOTATOC PET/CT guidance. Autoradiography of the biopsy specimen was performed and showed in situ correlation between Ga-68 DOTATOC uptake and histopathology with millimeter resolution.

Authors:
 [1];  [2];  [3];  [4];  [5];  [6];  [2];  [5];  [7]
  1. Memorial Sloan Kettering Cancer Center, Interventional Radiology Service (United States)
  2. Memorial Sloan Kettering Cancer Center, Molecular Imaging and Therapy Service, Department of Radiology (United States)
  3. Memorial Sloan Kettering Cancer Center, Orthopedic Surgical Oncology Service, Department of Surgery (United States)
  4. Memorial Sloan Kettering Cancer Center, Department of Pathology (United States)
  5. Memorial Sloan Kettering Cancer Center, Department of Physics (United States)
  6. Memorial Sloan Kettering Cancer Center, Department of Radiology (United States)
  7. Memorial Sloan Kettering Cancer Center, Department of Medicine (United States)
Publication Date:
OSTI Identifier:
22645463
Resource Type:
Journal Article
Resource Relation:
Journal Name: Cardiovascular and Interventional Radiology; Journal Volume: 39; Journal Issue: 9; Other Information: Copyright (c) 2016 Springer Science+Business Media New York and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE); http://www.springer-ny.com; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; AUTORADIOGRAPHY; BIOMEDICAL RADIOGRAPHY; BIOPSY; CONNECTIVE TISSUE; CORRELATIONS; DIAGNOSIS; DISEASE INCIDENCE; GALLIUM 68; NEOPLASMS; NMR IMAGING; PATIENTS; POSITRON COMPUTED TOMOGRAPHY; UPTAKE

Citation Formats

Maybody, Majid, E-mail: maybodym@mskcc.org, Grewal, Ravinder K., Healey, John H., Antonescu, Cristina R., Fanchon, Louise, Hwang, Sinchun, Carrasquillo, Jorge A., Kirov, Assen, and Farooki, Azeez. Ga-68 DOTATOC PET/CT-Guided Biopsy and Cryoablation with Autoradiography of Biopsy Specimen for Treatment of Tumor-Induced Osteomalacia. United States: N. p., 2016. Web. doi:10.1007/S00270-016-1350-1.
Maybody, Majid, E-mail: maybodym@mskcc.org, Grewal, Ravinder K., Healey, John H., Antonescu, Cristina R., Fanchon, Louise, Hwang, Sinchun, Carrasquillo, Jorge A., Kirov, Assen, & Farooki, Azeez. Ga-68 DOTATOC PET/CT-Guided Biopsy and Cryoablation with Autoradiography of Biopsy Specimen for Treatment of Tumor-Induced Osteomalacia. United States. doi:10.1007/S00270-016-1350-1.
Maybody, Majid, E-mail: maybodym@mskcc.org, Grewal, Ravinder K., Healey, John H., Antonescu, Cristina R., Fanchon, Louise, Hwang, Sinchun, Carrasquillo, Jorge A., Kirov, Assen, and Farooki, Azeez. Thu . "Ga-68 DOTATOC PET/CT-Guided Biopsy and Cryoablation with Autoradiography of Biopsy Specimen for Treatment of Tumor-Induced Osteomalacia". United States. doi:10.1007/S00270-016-1350-1.
@article{osti_22645463,
title = {Ga-68 DOTATOC PET/CT-Guided Biopsy and Cryoablation with Autoradiography of Biopsy Specimen for Treatment of Tumor-Induced Osteomalacia},
author = {Maybody, Majid, E-mail: maybodym@mskcc.org and Grewal, Ravinder K. and Healey, John H. and Antonescu, Cristina R. and Fanchon, Louise and Hwang, Sinchun and Carrasquillo, Jorge A. and Kirov, Assen and Farooki, Azeez},
abstractNote = {Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome caused by small benign tumors of mesenchymal origin also known as phosphaturic mesenchymal tumors mixed connective tissue variant. Excellent prognosis is expected with eradication of the culprit tumor. These small tumors are notoriously difficult to localize with conventional imaging studies; this often leads to an extensive work up and prolonged morbidity. We report a patient with clinical diagnosis of TIO whose culprit tumor was localized with Ga-68 DOTATOC PET/CT and MRI. Biopsy and cryoablation were performed under Ga-68 DOTATOC PET/CT guidance. Autoradiography of the biopsy specimen was performed and showed in situ correlation between Ga-68 DOTATOC uptake and histopathology with millimeter resolution.},
doi = {10.1007/S00270-016-1350-1},
journal = {Cardiovascular and Interventional Radiology},
number = 9,
volume = 39,
place = {United States},
year = {Thu Sep 15 00:00:00 EDT 2016},
month = {Thu Sep 15 00:00:00 EDT 2016}
}