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Title: TACE Combined with Implantation of Irradiation Stent Versus TACE Combine with Bare Stent for HCC Complicated by IVCTT

Abstract

PurposeThis study was designed to evaluate the safety and efficacy of transarterial chemoembolization (TACE) combined with intra-IVC implantation of an irradiation stent for the treatment of hepatocellular carcinoma (HCC) complicated by inferior vena cava tumor thrombosis (IVCTT).MethodsSixty-one consecutive patients with HCC complicated by IVCTT treated by TACE combined with IVC stenting were retrospectively analysed. IVC stenting was performed using a stent loaded with {sup 125}I seeds strands (the irradiation stent) in 33 patients (Group A) and 28 patients with a bare stent (Group B). Propensity score matching eliminated the baseline differences. Overall survival, oedema related to IVC obstruction remission rate and procedure-related adverse events were compared between the two groups.ResultsThe adverse effect rate was similar for both Group A and Group B patients, and complications were adequately handled by medical treatment. TACE combined with implantation of an irradiation stent showed a significant median survival benefit over TACE combined with a bare stent, with a median survival time of 203.0 ± 28.135 days versus 93.0 ± 24.341 days (p = 0.006). The propensity score-matched (24 pairs) cohort analyses (200 ± 31.231 days vs. 66 ± 23.270 days, p = 0.019). The oedema remission rate was 97.0 % in group A patients and 96.4 % in group B, respectively. TACE-irradiation stent and object tumor response were the independent prognostic factorsmore » of favorable survival.ConclusionsTACE combined with irradiation stent implantation is a safe and effective treatment modality for patients with HCC complicated by IVCTT and may extend their survival time.« less

Authors:
; ; ;  [1];  [2]; ; ;  [1]
  1. Fudan University, Department of Interventional Radiology, Zhongshan Hospital (China)
  2. Tengzhou Central People’s Hospital, Department of Oncology (China)
Publication Date:
OSTI Identifier:
22645458
Resource Type:
Journal Article
Resource Relation:
Journal Name: Cardiovascular and Interventional Radiology; Journal Volume: 39; Journal Issue: 9; Other Information: Copyright (c) 2016 Springer Science+Business Media New York and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE); http://www.springer-ny.com; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; BRACHYTHERAPY; COMPARATIVE EVALUATIONS; HEPATOMAS; IODINE 125; IRRADIATION; PATIENTS; SAFETY; SURVIVAL TIME; THROMBOSIS; VEINS

Citation Formats

Yang, Qing-hui, Zhang, Wen, Liu, Qing-xin, Liu, Ling-xiao, Wu, Lin-lin, Wang, Jian-hua, Yan, Zhi-ping, E-mail: 798373254@qq.com, and Luo, Jian-jun, E-mail: 12211210022@fudan.edu.cn. TACE Combined with Implantation of Irradiation Stent Versus TACE Combine with Bare Stent for HCC Complicated by IVCTT. United States: N. p., 2016. Web. doi:10.1007/S00270-016-1372-8.
Yang, Qing-hui, Zhang, Wen, Liu, Qing-xin, Liu, Ling-xiao, Wu, Lin-lin, Wang, Jian-hua, Yan, Zhi-ping, E-mail: 798373254@qq.com, & Luo, Jian-jun, E-mail: 12211210022@fudan.edu.cn. TACE Combined with Implantation of Irradiation Stent Versus TACE Combine with Bare Stent for HCC Complicated by IVCTT. United States. doi:10.1007/S00270-016-1372-8.
Yang, Qing-hui, Zhang, Wen, Liu, Qing-xin, Liu, Ling-xiao, Wu, Lin-lin, Wang, Jian-hua, Yan, Zhi-ping, E-mail: 798373254@qq.com, and Luo, Jian-jun, E-mail: 12211210022@fudan.edu.cn. Thu . "TACE Combined with Implantation of Irradiation Stent Versus TACE Combine with Bare Stent for HCC Complicated by IVCTT". United States. doi:10.1007/S00270-016-1372-8.
@article{osti_22645458,
title = {TACE Combined with Implantation of Irradiation Stent Versus TACE Combine with Bare Stent for HCC Complicated by IVCTT},
author = {Yang, Qing-hui and Zhang, Wen and Liu, Qing-xin and Liu, Ling-xiao and Wu, Lin-lin and Wang, Jian-hua and Yan, Zhi-ping, E-mail: 798373254@qq.com and Luo, Jian-jun, E-mail: 12211210022@fudan.edu.cn},
abstractNote = {PurposeThis study was designed to evaluate the safety and efficacy of transarterial chemoembolization (TACE) combined with intra-IVC implantation of an irradiation stent for the treatment of hepatocellular carcinoma (HCC) complicated by inferior vena cava tumor thrombosis (IVCTT).MethodsSixty-one consecutive patients with HCC complicated by IVCTT treated by TACE combined with IVC stenting were retrospectively analysed. IVC stenting was performed using a stent loaded with {sup 125}I seeds strands (the irradiation stent) in 33 patients (Group A) and 28 patients with a bare stent (Group B). Propensity score matching eliminated the baseline differences. Overall survival, oedema related to IVC obstruction remission rate and procedure-related adverse events were compared between the two groups.ResultsThe adverse effect rate was similar for both Group A and Group B patients, and complications were adequately handled by medical treatment. TACE combined with implantation of an irradiation stent showed a significant median survival benefit over TACE combined with a bare stent, with a median survival time of 203.0 ± 28.135 days versus 93.0 ± 24.341 days (p = 0.006). The propensity score-matched (24 pairs) cohort analyses (200 ± 31.231 days vs. 66 ± 23.270 days, p = 0.019). The oedema remission rate was 97.0 % in group A patients and 96.4 % in group B, respectively. TACE-irradiation stent and object tumor response were the independent prognostic factors of favorable survival.ConclusionsTACE combined with irradiation stent implantation is a safe and effective treatment modality for patients with HCC complicated by IVCTT and may extend their survival time.},
doi = {10.1007/S00270-016-1372-8},
journal = {Cardiovascular and Interventional Radiology},
number = 9,
volume = 39,
place = {United States},
year = {Thu Sep 15 00:00:00 EDT 2016},
month = {Thu Sep 15 00:00:00 EDT 2016}
}