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Title: PET/MRI of Hepatic 90Y Microsphere Deposition Determines Individual Tumor Response

Abstract

PurposeThe purpose of our study is to determine if there is a relationship between dose deposition measured by PET/MRI and individual lesion response to yttrium-90 ({sup 90}Y) microsphere radioembolization.Materials and Methods26 patients undergoing lobar treatment with {sup 90}Y microspheres underwent PET/MRI within 66 h of treatment and had follow-up imaging available. Adequate visualization of tumor was available in 24 patients, and contours were drawn on simultaneously acquired PET/MRI data. Dose volume histograms (DVHs) were extracted from dose maps, which were generated using a voxelized dose kernel. Similar contours to capture dimensional and volumetric change of tumors were drawn on follow-up imaging. Response was analyzed using both RECIST and volumetric RECIST (vRECIST) criteria.ResultsA total of 8 hepatocellular carcinoma (HCC), 4 neuroendocrine tumor (NET), 9 colorectal metastases (CRC) patients, and 3 patients with other metastatic disease met inclusion criteria. Average dose was useful in predicting response between responders and non-responders for all lesion types and for CRC lesions alone using both response criteria (p < 0.05). D70 (minimum dose to 70 % of volume) was also useful in predicting response when using vRECIST. No significant trend was seen in the other tumor types. For CRC lesions, an average dose of 29.8 Gy offered 76.9 % sensitivity and 75.9 %more » specificity for response.ConclusionsPET/MRI of {sup 90}Y microsphere distribution showed significantly higher DVH values for responders than non-responders in patients with CRC. DVH analysis of {sup 90}Y microsphere distribution following treatment may be an important predictor of response and could be used to guide future adaptive therapy trials.« less

Authors:
 [1];  [2];  [3];  [1];  [3]; ; ;  [4]
  1. Washington University, Department of Radiology (United States)
  2. Washington University, Department of Biomedical Engineering (United States)
  3. Washington University, Department of Nuclear Medicine (United States)
  4. Washington University, Department of Radiation Oncology (United States)
Publication Date:
OSTI Identifier:
22642510
Resource Type:
Journal Article
Resource Relation:
Journal Name: Cardiovascular and Interventional Radiology; Journal Volume: 39; Journal Issue: 6; Other Information: Copyright (c) 2016 Springer Science+Business Media New York and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE); Article Copyright (c) 2015 The Author(s); http://www.springer-ny.com; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; BIOMEDICAL RADIOGRAPHY; HEPATOMAS; LIVER; METASTASES; MICROSPHERES; NMR IMAGING; PATIENTS; POSITRON COMPUTED TOMOGRAPHY; RADIATION DOSES; RADIOEMBOLIZATION; YTTRIUM 90

Citation Formats

Fowler, Kathryn J., Maughan, Nichole M., Laforest, Richard, Saad, Nael E., Sharma, Akash, Olsen, Jeffrey, Speirs, Christina K., and Parikh, Parag J., E-mail: parikh@wustl.edu. PET/MRI of Hepatic 90Y Microsphere Deposition Determines Individual Tumor Response. United States: N. p., 2016. Web. doi:10.1007/S00270-015-1285-Y.
Fowler, Kathryn J., Maughan, Nichole M., Laforest, Richard, Saad, Nael E., Sharma, Akash, Olsen, Jeffrey, Speirs, Christina K., & Parikh, Parag J., E-mail: parikh@wustl.edu. PET/MRI of Hepatic 90Y Microsphere Deposition Determines Individual Tumor Response. United States. doi:10.1007/S00270-015-1285-Y.
Fowler, Kathryn J., Maughan, Nichole M., Laforest, Richard, Saad, Nael E., Sharma, Akash, Olsen, Jeffrey, Speirs, Christina K., and Parikh, Parag J., E-mail: parikh@wustl.edu. Wed . "PET/MRI of Hepatic 90Y Microsphere Deposition Determines Individual Tumor Response". United States. doi:10.1007/S00270-015-1285-Y.
@article{osti_22642510,
title = {PET/MRI of Hepatic 90Y Microsphere Deposition Determines Individual Tumor Response},
author = {Fowler, Kathryn J. and Maughan, Nichole M. and Laforest, Richard and Saad, Nael E. and Sharma, Akash and Olsen, Jeffrey and Speirs, Christina K. and Parikh, Parag J., E-mail: parikh@wustl.edu},
abstractNote = {PurposeThe purpose of our study is to determine if there is a relationship between dose deposition measured by PET/MRI and individual lesion response to yttrium-90 ({sup 90}Y) microsphere radioembolization.Materials and Methods26 patients undergoing lobar treatment with {sup 90}Y microspheres underwent PET/MRI within 66 h of treatment and had follow-up imaging available. Adequate visualization of tumor was available in 24 patients, and contours were drawn on simultaneously acquired PET/MRI data. Dose volume histograms (DVHs) were extracted from dose maps, which were generated using a voxelized dose kernel. Similar contours to capture dimensional and volumetric change of tumors were drawn on follow-up imaging. Response was analyzed using both RECIST and volumetric RECIST (vRECIST) criteria.ResultsA total of 8 hepatocellular carcinoma (HCC), 4 neuroendocrine tumor (NET), 9 colorectal metastases (CRC) patients, and 3 patients with other metastatic disease met inclusion criteria. Average dose was useful in predicting response between responders and non-responders for all lesion types and for CRC lesions alone using both response criteria (p < 0.05). D70 (minimum dose to 70 % of volume) was also useful in predicting response when using vRECIST. No significant trend was seen in the other tumor types. For CRC lesions, an average dose of 29.8 Gy offered 76.9 % sensitivity and 75.9 % specificity for response.ConclusionsPET/MRI of {sup 90}Y microsphere distribution showed significantly higher DVH values for responders than non-responders in patients with CRC. DVH analysis of {sup 90}Y microsphere distribution following treatment may be an important predictor of response and could be used to guide future adaptive therapy trials.},
doi = {10.1007/S00270-015-1285-Y},
journal = {Cardiovascular and Interventional Radiology},
number = 6,
volume = 39,
place = {United States},
year = {Wed Jun 15 00:00:00 EDT 2016},
month = {Wed Jun 15 00:00:00 EDT 2016}
}