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Title: SU-C-207A-04: Accuracy of Acoustic-Based Proton Range Verification in Water

Abstract

Purpose: To determine the accuracy and dose required for acoustic-based proton range verification (protoacoustics) in water. Methods: Proton pulses with 17 µs FWHM and instantaneous currents of 480 nA (5.6 × 10{sup 7} protons/pulse, 8.9 cGy/pulse) were generated by a clinical, hospital-based cyclotron at the University of Pennsylvania. The protoacoustic signal generated in a water phantom by the 190 MeV proton pulses was measured with a hydrophone placed at multiple known positions surrounding the dose deposition. The background random noise was measured. The protoacoustic signal was simulated to compare to the experiments. Results: The maximum protoacoustic signal amplitude at 5 cm distance was 5.2 mPa per 1 × 10{sup 7} protons (1.6 cGy at the Bragg peak). The background random noise of the measurement was 27 mPa. Comparison between simulation and experiment indicates that the hydrophone introduced a delay of 2.4 µs. For acoustic data collected with a signal-to-noise ratio (SNR) of 21, deconvolution of the protoacoustic signal with the proton pulse provided the most precise time-of-flight range measurement (standard deviation of 2.0 mm), but a systematic error (−4.5 mm) was observed. Conclusion: Based on water phantom measurements at a clinical hospital-based cyclotron, protoacoustics is a potential technique for measuringmore » the proton Bragg peak range with 2.0 mm standard deviation. Simultaneous use of multiple detectors is expected to reduce the standard deviation, but calibration is required to remove systematic error. Based on the measured background noise and protoacoustic amplitude, a SNR of 5.3 is projected for a deposited dose of 2 Gy.« less

Authors:
; ;  [1];  [2]
  1. University of Pennsylvania, Philadelphia, PA (United States)
  2. Ion Beam Applications (IBA), Louvainla-neuve, Walloon Brabant (Belgium)
Publication Date:
OSTI Identifier:
22624339
Resource Type:
Journal Article
Resource Relation:
Journal Name: Medical Physics; Journal Volume: 43; Journal Issue: 6; Other Information: (c) 2016 American Association of Physicists in Medicine; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
61 RADIATION PROTECTION AND DOSIMETRY; 60 APPLIED LIFE SCIENCES; ACCURACY; ACOUSTICS; AMPLITUDES; BACKGROUND NOISE; BRAGG CURVE; CYCLOTRONS; ERRORS; HOSPITALS; PHANTOMS; RADIATION DOSES; SIGNAL-TO-NOISE RATIO; SIMULATION; VERIFICATION

Citation Formats

Jones, KC, Sehgal, CM, Avery, S, and Vander Stappen, F. SU-C-207A-04: Accuracy of Acoustic-Based Proton Range Verification in Water. United States: N. p., 2016. Web. doi:10.1118/1.4955579.
Jones, KC, Sehgal, CM, Avery, S, & Vander Stappen, F. SU-C-207A-04: Accuracy of Acoustic-Based Proton Range Verification in Water. United States. doi:10.1118/1.4955579.
Jones, KC, Sehgal, CM, Avery, S, and Vander Stappen, F. Wed . "SU-C-207A-04: Accuracy of Acoustic-Based Proton Range Verification in Water". United States. doi:10.1118/1.4955579.
@article{osti_22624339,
title = {SU-C-207A-04: Accuracy of Acoustic-Based Proton Range Verification in Water},
author = {Jones, KC and Sehgal, CM and Avery, S and Vander Stappen, F},
abstractNote = {Purpose: To determine the accuracy and dose required for acoustic-based proton range verification (protoacoustics) in water. Methods: Proton pulses with 17 µs FWHM and instantaneous currents of 480 nA (5.6 × 10{sup 7} protons/pulse, 8.9 cGy/pulse) were generated by a clinical, hospital-based cyclotron at the University of Pennsylvania. The protoacoustic signal generated in a water phantom by the 190 MeV proton pulses was measured with a hydrophone placed at multiple known positions surrounding the dose deposition. The background random noise was measured. The protoacoustic signal was simulated to compare to the experiments. Results: The maximum protoacoustic signal amplitude at 5 cm distance was 5.2 mPa per 1 × 10{sup 7} protons (1.6 cGy at the Bragg peak). The background random noise of the measurement was 27 mPa. Comparison between simulation and experiment indicates that the hydrophone introduced a delay of 2.4 µs. For acoustic data collected with a signal-to-noise ratio (SNR) of 21, deconvolution of the protoacoustic signal with the proton pulse provided the most precise time-of-flight range measurement (standard deviation of 2.0 mm), but a systematic error (−4.5 mm) was observed. Conclusion: Based on water phantom measurements at a clinical hospital-based cyclotron, protoacoustics is a potential technique for measuring the proton Bragg peak range with 2.0 mm standard deviation. Simultaneous use of multiple detectors is expected to reduce the standard deviation, but calibration is required to remove systematic error. Based on the measured background noise and protoacoustic amplitude, a SNR of 5.3 is projected for a deposited dose of 2 Gy.},
doi = {10.1118/1.4955579},
journal = {Medical Physics},
number = 6,
volume = 43,
place = {United States},
year = {Wed Jun 15 00:00:00 EDT 2016},
month = {Wed Jun 15 00:00:00 EDT 2016}
}