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Title: Quantification of regional early stage gas exchange changes using hyperpolarized {sup 129}Xe MRI in a rat model of radiation-induced lung injury

Abstract

Purpose: To assess the feasibility of hyperpolarized (HP) {sup 129}Xe MRI for detection of early stage radiation-induced lung injury (RILI) in a rat model involving unilateral irradiation by assessing differences in gas exchange dynamics between irradiated and unirradiated lungs. Methods: The dynamics of gas exchange between alveolar air space and pulmonary tissue (PT), PT and red blood cells (RBCs) was measured using single-shot spiral iterative decomposition of water and fat with echo asymmetry and least-squares estimation images of the right and left lungs of two age-matched cohorts of Sprague Dawley rats. The first cohort (n = 5) received 18 Gy irradiation to the right lung using a {sup 60}Co source and the second cohort (n = 5) was not irradiated and served as the healthy control. Both groups were imaged two weeks following irradiation when radiation pneumonitis (RP) was expected to be present. The gas exchange data were fit to a theoretical gas exchange model to extract measurements of pulmonary tissue thickness (L{sub PT}) and relative blood volume (V{sub RBC}) from each of the right and left lungs of both cohorts. Following imaging, lung specimens were retrieved and percent tissue area (PTA) was assessed histologically to confirm RP and correlatemore » with MRI measurements. Results: Statistically significant differences in L{sub PT} and V{sub RBC} were observed between the irradiated and non-irradiated cohorts. In particular, L{sub PT} of the right and left lungs was increased approximately 8.2% and 5.0% respectively in the irradiated cohort. Additionally, V{sub RBC} of the right and left lungs was decreased approximately 36.1% and 11.7% respectively for the irradiated cohort compared to the non-irradiated cohort. PTA measurements in both right and left lungs were increased in the irradiated group compared to the non-irradiated cohort for both the left (P < 0.05) and right lungs (P < 0.01) confirming the presence of RP. PTA measurements also correlated with the MRI measurements for both the non-irradiated (r = 0.79, P < 0.01) and irradiated groups (r = 0.91, P < 0.01). Conclusions: Regional RILI can be detected two weeks post-irradiation using HP {sup 129}Xe MRI and analysis of gas exchange curves. This approach correlates well with histology and can potentially be used clinically to assess radiation pneumonitis associated with early RILI to improve radiation therapy outcomes.« less

Authors:
 [1];  [2];  [3];  [4];  [1];  [2];  [5];  [1];  [2];  [2];  [2]
  1. Department of Medical Biophysics, Western University, London, Ontario N6A5C1 (Canada)
  2. (Canada)
  3. (United Kingdom)
  4. Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G1X8 (Canada)
  5. General Electric Global Research, Munich 85748 (Germany)
Publication Date:
OSTI Identifier:
22620893
Resource Type:
Journal Article
Resource Relation:
Journal Name: Medical Physics; Journal Volume: 43; Journal Issue: 5; Other Information: (c) 2016 American Association of Physicists in Medicine; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; 61 RADIATION PROTECTION AND DOSIMETRY; ANIMAL TISSUES; ASYMMETRY; BIOMEDICAL RADIOGRAPHY; BLOOD CELLS; IMAGES; INJURIES; IRRADIATION; ITERATIVE METHODS; LUNGS; NMR IMAGING; PNEUMONITIS; RADIOTHERAPY; RATS; THICKNESS; XENON 129

Citation Formats

Doganay, Ozkan, E-mail: ozkan.doganay@oncology.ox.ac.uk, Imaging Research Laboratories, Robarts Research Institute, London, Ontario N6A5C1, Department of Oncology, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford OX3 7DQ, Stirrat, Elaine, McKenzie, Charles, Imaging Research Laboratories, Robarts Research Institute, London, Ontario N6A5C1, Schulte, Rolf F., Santyr, Giles E., Imaging Research Laboratories, Robarts Research Institute, London, Ontario N6A5C1, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G1X8, and Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5G1L7. Quantification of regional early stage gas exchange changes using hyperpolarized {sup 129}Xe MRI in a rat model of radiation-induced lung injury. United States: N. p., 2016. Web. doi:10.1118/1.4946818.
Doganay, Ozkan, E-mail: ozkan.doganay@oncology.ox.ac.uk, Imaging Research Laboratories, Robarts Research Institute, London, Ontario N6A5C1, Department of Oncology, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford OX3 7DQ, Stirrat, Elaine, McKenzie, Charles, Imaging Research Laboratories, Robarts Research Institute, London, Ontario N6A5C1, Schulte, Rolf F., Santyr, Giles E., Imaging Research Laboratories, Robarts Research Institute, London, Ontario N6A5C1, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G1X8, & Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5G1L7. Quantification of regional early stage gas exchange changes using hyperpolarized {sup 129}Xe MRI in a rat model of radiation-induced lung injury. United States. doi:10.1118/1.4946818.
Doganay, Ozkan, E-mail: ozkan.doganay@oncology.ox.ac.uk, Imaging Research Laboratories, Robarts Research Institute, London, Ontario N6A5C1, Department of Oncology, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford OX3 7DQ, Stirrat, Elaine, McKenzie, Charles, Imaging Research Laboratories, Robarts Research Institute, London, Ontario N6A5C1, Schulte, Rolf F., Santyr, Giles E., Imaging Research Laboratories, Robarts Research Institute, London, Ontario N6A5C1, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G1X8, and Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5G1L7. Sun . "Quantification of regional early stage gas exchange changes using hyperpolarized {sup 129}Xe MRI in a rat model of radiation-induced lung injury". United States. doi:10.1118/1.4946818.
@article{osti_22620893,
title = {Quantification of regional early stage gas exchange changes using hyperpolarized {sup 129}Xe MRI in a rat model of radiation-induced lung injury},
author = {Doganay, Ozkan, E-mail: ozkan.doganay@oncology.ox.ac.uk and Imaging Research Laboratories, Robarts Research Institute, London, Ontario N6A5C1 and Department of Oncology, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford OX3 7DQ and Stirrat, Elaine and McKenzie, Charles and Imaging Research Laboratories, Robarts Research Institute, London, Ontario N6A5C1 and Schulte, Rolf F. and Santyr, Giles E. and Imaging Research Laboratories, Robarts Research Institute, London, Ontario N6A5C1 and Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G1X8 and Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5G1L7},
abstractNote = {Purpose: To assess the feasibility of hyperpolarized (HP) {sup 129}Xe MRI for detection of early stage radiation-induced lung injury (RILI) in a rat model involving unilateral irradiation by assessing differences in gas exchange dynamics between irradiated and unirradiated lungs. Methods: The dynamics of gas exchange between alveolar air space and pulmonary tissue (PT), PT and red blood cells (RBCs) was measured using single-shot spiral iterative decomposition of water and fat with echo asymmetry and least-squares estimation images of the right and left lungs of two age-matched cohorts of Sprague Dawley rats. The first cohort (n = 5) received 18 Gy irradiation to the right lung using a {sup 60}Co source and the second cohort (n = 5) was not irradiated and served as the healthy control. Both groups were imaged two weeks following irradiation when radiation pneumonitis (RP) was expected to be present. The gas exchange data were fit to a theoretical gas exchange model to extract measurements of pulmonary tissue thickness (L{sub PT}) and relative blood volume (V{sub RBC}) from each of the right and left lungs of both cohorts. Following imaging, lung specimens were retrieved and percent tissue area (PTA) was assessed histologically to confirm RP and correlate with MRI measurements. Results: Statistically significant differences in L{sub PT} and V{sub RBC} were observed between the irradiated and non-irradiated cohorts. In particular, L{sub PT} of the right and left lungs was increased approximately 8.2% and 5.0% respectively in the irradiated cohort. Additionally, V{sub RBC} of the right and left lungs was decreased approximately 36.1% and 11.7% respectively for the irradiated cohort compared to the non-irradiated cohort. PTA measurements in both right and left lungs were increased in the irradiated group compared to the non-irradiated cohort for both the left (P < 0.05) and right lungs (P < 0.01) confirming the presence of RP. PTA measurements also correlated with the MRI measurements for both the non-irradiated (r = 0.79, P < 0.01) and irradiated groups (r = 0.91, P < 0.01). Conclusions: Regional RILI can be detected two weeks post-irradiation using HP {sup 129}Xe MRI and analysis of gas exchange curves. This approach correlates well with histology and can potentially be used clinically to assess radiation pneumonitis associated with early RILI to improve radiation therapy outcomes.},
doi = {10.1118/1.4946818},
journal = {Medical Physics},
number = 5,
volume = 43,
place = {United States},
year = {Sun May 15 00:00:00 EDT 2016},
month = {Sun May 15 00:00:00 EDT 2016}
}