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Title: Photon-counting hexagonal pixel array CdTe detector: Spatial resolution characteristics for image-guided interventional applications

Abstract

Purpose: High-resolution, photon-counting, energy-resolved detector with fast-framing capability can facilitate simultaneous acquisition of precontrast and postcontrast images for subtraction angiography without pixel registration artifacts and can facilitate high-resolution real-time imaging during image-guided interventions. Hence, this study was conducted to determine the spatial resolution characteristics of a hexagonal pixel array photon-counting cadmium telluride (CdTe) detector. Methods: A 650 μm thick CdTe Schottky photon-counting detector capable of concurrently acquiring up to two energy-windowed images was operated in a single energy-window mode to include photons of 10 keV or higher. The detector had hexagonal pixels with apothem of 30 μm resulting in pixel pitch of 60 and 51.96 μm along the two orthogonal directions. The detector was characterized at IEC-RQA5 spectral conditions. Linear response of the detector was determined over the air kerma rate relevant to image-guided interventional procedures ranging from 1.3 nGy/frame to 91.4 μGy/frame. Presampled modulation transfer was determined using a tungsten edge test device. The edge-spread function and the finely sampled line spread function accounted for hexagonal sampling, from which the presampled modulation transfer function (MTF) was determined. Since detectors with hexagonal pixels require resampling to square pixels for distortion-free display, the optimal square pixel size was determined by minimizingmore » the root-mean-squared-error of the aperture functions for the square and hexagonal pixels up to the Nyquist limit. Results: At Nyquist frequencies of 8.33 and 9.62 cycles/mm along the apothem and orthogonal to the apothem directions, the modulation factors were 0.397 and 0.228, respectively. For the corresponding axis, the limiting resolution defined as 10% MTF occurred at 13.3 and 12 cycles/mm, respectively. Evaluation of the aperture functions yielded an optimal square pixel size of 54 μm. After resampling to 54 μm square pixels using trilinear interpolation, the presampled MTF at Nyquist frequency of 9.26 cycles/mm was 0.29 and 0.24 along the orthogonal directions and the limiting resolution (10% MTF) occurred at approximately 12 cycles/mm. Visual analysis of a bar pattern image showed the ability to resolve close to 12 line-pairs/mm and qualitative evaluation of a neurovascular nitinol-stent showed the ability to visualize its struts at clinically relevant conditions. Conclusions: Hexagonal pixel array photon-counting CdTe detector provides high spatial resolution in single-photon counting mode. After resampling to optimal square pixel size for distortion-free display, the spatial resolution is preserved. The dual-energy capabilities of the detector could allow for artifact-free subtraction angiography and basis material decomposition. The proposed high-resolution photon-counting detector with energy-resolving capability can be of importance for several image-guided interventional procedures as well as for pediatric applications.« less

Authors:
; ; ; ;  [1]; ; ; ;  [2]
  1. Department of Radiology, University of Massachusetts Medical School, Worcester, Massachusetts 01655 (United States)
  2. Istituto Nazionale di Fisica Nucleare (INFN), Pisa 56127, Italy and Pixirad Imaging Counters s.r.l., L. Pontecorvo 3, Pisa 56127 (Italy)
Publication Date:
OSTI Identifier:
22620873
Resource Type:
Journal Article
Resource Relation:
Journal Name: Medical Physics; Journal Volume: 43; Journal Issue: 5; Other Information: (c) 2016 American Association of Physicists in Medicine; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND TECHNOLOGY; APERTURES; BIOMEDICAL RADIOGRAPHY; BLOOD VESSELS; CDTE SEMICONDUCTOR DETECTORS; IMAGES; MODULATION; NICKEL ALLOYS; PEDIATRICS; SPATIAL RESOLUTION; TITANIUM ALLOYS; TRANSFER FUNCTIONS; TUNGSTEN; PHOTON COUNTING

Citation Formats

Vedantham, Srinivasan, Shrestha, Suman, Karellas, Andrew, E-mail: andrew.karellas@umassmed.edu, Shi, Linxi, Gounis, Matthew J., Bellazzini, Ronaldo, Spandre, Gloria, Brez, Alessandro, and Minuti, Massimo. Photon-counting hexagonal pixel array CdTe detector: Spatial resolution characteristics for image-guided interventional applications. United States: N. p., 2016. Web. doi:10.1118/1.4944868.
Vedantham, Srinivasan, Shrestha, Suman, Karellas, Andrew, E-mail: andrew.karellas@umassmed.edu, Shi, Linxi, Gounis, Matthew J., Bellazzini, Ronaldo, Spandre, Gloria, Brez, Alessandro, & Minuti, Massimo. Photon-counting hexagonal pixel array CdTe detector: Spatial resolution characteristics for image-guided interventional applications. United States. doi:10.1118/1.4944868.
Vedantham, Srinivasan, Shrestha, Suman, Karellas, Andrew, E-mail: andrew.karellas@umassmed.edu, Shi, Linxi, Gounis, Matthew J., Bellazzini, Ronaldo, Spandre, Gloria, Brez, Alessandro, and Minuti, Massimo. 2016. "Photon-counting hexagonal pixel array CdTe detector: Spatial resolution characteristics for image-guided interventional applications". United States. doi:10.1118/1.4944868.
@article{osti_22620873,
title = {Photon-counting hexagonal pixel array CdTe detector: Spatial resolution characteristics for image-guided interventional applications},
author = {Vedantham, Srinivasan and Shrestha, Suman and Karellas, Andrew, E-mail: andrew.karellas@umassmed.edu and Shi, Linxi and Gounis, Matthew J. and Bellazzini, Ronaldo and Spandre, Gloria and Brez, Alessandro and Minuti, Massimo},
abstractNote = {Purpose: High-resolution, photon-counting, energy-resolved detector with fast-framing capability can facilitate simultaneous acquisition of precontrast and postcontrast images for subtraction angiography without pixel registration artifacts and can facilitate high-resolution real-time imaging during image-guided interventions. Hence, this study was conducted to determine the spatial resolution characteristics of a hexagonal pixel array photon-counting cadmium telluride (CdTe) detector. Methods: A 650 μm thick CdTe Schottky photon-counting detector capable of concurrently acquiring up to two energy-windowed images was operated in a single energy-window mode to include photons of 10 keV or higher. The detector had hexagonal pixels with apothem of 30 μm resulting in pixel pitch of 60 and 51.96 μm along the two orthogonal directions. The detector was characterized at IEC-RQA5 spectral conditions. Linear response of the detector was determined over the air kerma rate relevant to image-guided interventional procedures ranging from 1.3 nGy/frame to 91.4 μGy/frame. Presampled modulation transfer was determined using a tungsten edge test device. The edge-spread function and the finely sampled line spread function accounted for hexagonal sampling, from which the presampled modulation transfer function (MTF) was determined. Since detectors with hexagonal pixels require resampling to square pixels for distortion-free display, the optimal square pixel size was determined by minimizing the root-mean-squared-error of the aperture functions for the square and hexagonal pixels up to the Nyquist limit. Results: At Nyquist frequencies of 8.33 and 9.62 cycles/mm along the apothem and orthogonal to the apothem directions, the modulation factors were 0.397 and 0.228, respectively. For the corresponding axis, the limiting resolution defined as 10% MTF occurred at 13.3 and 12 cycles/mm, respectively. Evaluation of the aperture functions yielded an optimal square pixel size of 54 μm. After resampling to 54 μm square pixels using trilinear interpolation, the presampled MTF at Nyquist frequency of 9.26 cycles/mm was 0.29 and 0.24 along the orthogonal directions and the limiting resolution (10% MTF) occurred at approximately 12 cycles/mm. Visual analysis of a bar pattern image showed the ability to resolve close to 12 line-pairs/mm and qualitative evaluation of a neurovascular nitinol-stent showed the ability to visualize its struts at clinically relevant conditions. Conclusions: Hexagonal pixel array photon-counting CdTe detector provides high spatial resolution in single-photon counting mode. After resampling to optimal square pixel size for distortion-free display, the spatial resolution is preserved. The dual-energy capabilities of the detector could allow for artifact-free subtraction angiography and basis material decomposition. The proposed high-resolution photon-counting detector with energy-resolving capability can be of importance for several image-guided interventional procedures as well as for pediatric applications.},
doi = {10.1118/1.4944868},
journal = {Medical Physics},
number = 5,
volume = 43,
place = {United States},
year = 2016,
month = 5
}
  • Purpose: Detectors with hexagonal pixels require resampling to square pixels for distortion-free display of acquired images. In this work, the presampling modulation transfer function (MTF) of a hexagonal pixel array photon-counting CdTe detector for region-of-interest fluoroscopy was measured and the optimal square pixel size for resampling was determined. Methods: A 0.65mm thick CdTe Schottky sensor capable of concurrently acquiring up to 3 energy-windowed images was operated in a single energy-window mode to include ≥10 KeV photons. The detector had hexagonal pixels with apothem of 30 microns resulting in pixel spacing of 60 and 51.96 microns along the two orthogonal directions.more » Images of a tungsten edge test device acquired under IEC RQA5 conditions were double Hough transformed to identify the edge and numerically differentiated. The presampling MTF was determined from the finely sampled line spread function that accounted for the hexagonal sampling. The optimal square pixel size was determined in two ways; the square pixel size for which the aperture function evaluated at the Nyquist frequencies along the two orthogonal directions matched that from the hexagonal pixel aperture functions, and the square pixel size for which the mean absolute difference between the square and hexagonal aperture functions was minimized over all frequencies up to the Nyquist limit. Results: Evaluation of the aperture functions over the entire frequency range resulted in square pixel size of 53 microns with less than 2% difference from the hexagonal pixel. Evaluation of the aperture functions at Nyquist frequencies alone resulted in 54 microns square pixels. For the photon-counting CdTe detector and after resampling to 53 microns square pixels using quadratic interpolation, the presampling MTF at Nyquist frequency of 9.434 cycles/mm along the two directions were 0.501 and 0.507. Conclusion: Hexagonal pixel array photon-counting CdTe detector after resampling to square pixels provides high-resolution imaging suitable for fluoroscopy.« less
  • Medipix3 is a single photon-counting pixel readout chip whose new front-end architecture aims to eliminate the spectral distortion produced by charge diffusion in highly segmented semiconductor detectors. The chip requires area and power-efficient reconfigurable digital counters and shift registers that can be integrated with other photon-processing analog and digital circuits within the 55 {mu}mx55 {mu}m pixel area. This work proposes a configurable-depth, programmable mode digital counter for use in Medipix3.
  • The XPAD detector is a 2D X-ray imager based on hybrid pixel technology, gathering 38400 pixels on a surface of 68*68 mm2. It is a photon counting detector, with low noise, wide dynamic range and high speed read out, which make it particularly suitable for third generation synchrotron applications, such as diffraction, small angle X-ray scattering or macro-molecular crystallography, but also for small animal imaging. High resolution powder diffraction data and in situ scattering data of crystallization of liquid oxides are presented to illustrate the properties of this detector, resulting in a significant gain in data acquisition time and amore » capability to follow fast kinetics in real time experiments. The characteristics of the future generation of XPAD detector, which will be available in 2007, are also presented.« less