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Title: Reverse depletion effects and the determination of ligand density on some spherical bioparticles

Abstract

In cell environments crowded with macromolecules, the depletion effects act and assist in the assembly of a wide range of cellular structures, from the cytoskeleton to the chromatin loop, which are well accepted. But a recent quantum dot experiment indicated that the dimensions of the receptor–ligand complex have strong effects on the size-dependent exclusion of proteins in cell environments. In this article, a continuum elastic model is constructed to resolve the competition between the dimension of the receptor–ligand complex and depletion effects in the endocytosis of a spherical virus-like bioparticle. Our results show that the depletion effects do not always assist endocytosis of a spherical virus-like bioparticle; while the dimension of the ligand–receptor complex is larger than the size of a small bioparticle in cell environments, the depletion effects do not work and reverse effects appear. The ligand density covered on the virus can be identified quantitatively.

Authors:
 [1]; ; ; ; ;  [2]
  1. Heilongjiang Bayi Agricultural University (China)
  2. Guizhou University (China)
Publication Date:
OSTI Identifier:
22617237
Resource Type:
Journal Article
Resource Relation:
Journal Name: Journal of Experimental and Theoretical Physics; Journal Volume: 122; Journal Issue: 6; Other Information: Copyright (c) 2016 Pleiades Publishing, Inc.; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
75 CONDENSED MATTER PHYSICS, SUPERCONDUCTIVITY AND SUPERFLUIDITY; CHROMATIN; COMPETITION; COMPLEXES; DENSITY; LIGANDS; MICROTUBULES; QUANTUM DOTS; RECEPTORS; SIMULATION; SPHERICAL CONFIGURATION; VIRUSES

Citation Formats

Wang, Chunxiang, Liu, Yanhui, E-mail: ionazati@itp.ac.cn, Fan, Yangtao, Liu, Yijun, Li, Qiancheng, and Xu, Houqiang, E-mail: houqiangxu@yahoo.com. Reverse depletion effects and the determination of ligand density on some spherical bioparticles. United States: N. p., 2016. Web. doi:10.1134/S1063776116050228.
Wang, Chunxiang, Liu, Yanhui, E-mail: ionazati@itp.ac.cn, Fan, Yangtao, Liu, Yijun, Li, Qiancheng, & Xu, Houqiang, E-mail: houqiangxu@yahoo.com. Reverse depletion effects and the determination of ligand density on some spherical bioparticles. United States. doi:10.1134/S1063776116050228.
Wang, Chunxiang, Liu, Yanhui, E-mail: ionazati@itp.ac.cn, Fan, Yangtao, Liu, Yijun, Li, Qiancheng, and Xu, Houqiang, E-mail: houqiangxu@yahoo.com. 2016. "Reverse depletion effects and the determination of ligand density on some spherical bioparticles". United States. doi:10.1134/S1063776116050228.
@article{osti_22617237,
title = {Reverse depletion effects and the determination of ligand density on some spherical bioparticles},
author = {Wang, Chunxiang and Liu, Yanhui, E-mail: ionazati@itp.ac.cn and Fan, Yangtao and Liu, Yijun and Li, Qiancheng and Xu, Houqiang, E-mail: houqiangxu@yahoo.com},
abstractNote = {In cell environments crowded with macromolecules, the depletion effects act and assist in the assembly of a wide range of cellular structures, from the cytoskeleton to the chromatin loop, which are well accepted. But a recent quantum dot experiment indicated that the dimensions of the receptor–ligand complex have strong effects on the size-dependent exclusion of proteins in cell environments. In this article, a continuum elastic model is constructed to resolve the competition between the dimension of the receptor–ligand complex and depletion effects in the endocytosis of a spherical virus-like bioparticle. Our results show that the depletion effects do not always assist endocytosis of a spherical virus-like bioparticle; while the dimension of the ligand–receptor complex is larger than the size of a small bioparticle in cell environments, the depletion effects do not work and reverse effects appear. The ligand density covered on the virus can be identified quantitatively.},
doi = {10.1134/S1063776116050228},
journal = {Journal of Experimental and Theoretical Physics},
number = 6,
volume = 122,
place = {United States},
year = 2016,
month = 6
}
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