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Title: The life science x-ray scattering beamline at NSLS-II

Abstract

We report the current development status of the High Brightness X-ray Scattering for Life Sciences (or Life Science X-ray Scattering, LiX) beamline at the NSLS-II facility of Brookhaven National Laboratory. This instrument will operate in the x-ray energy range of 2.1-18 keV, provide variable beam sizes from 1 micron to ∼0.5 mm, and support user experiments in three scientific areas: (1) high-throughput solution scattering, in-line size exclusion chromatography and flow mixers-based time-resolved solution scattering of biological macro-molecules, (2) diffraction from single- and multi-layered lipid membranes, and (3) scattering-based scanning probe imaging of biological tissues. In order to satisfy the beam stability required for these experiments and to switch rapidly between different types of experiments, we have adopted a secondary source with refractive lenses for secondary focusing, a detector system consisting of three Pilatus detectors, and specialized experimental modules that can be quickly exchanged and each dedicated to a defined set of experiments. The construction of this beamline is on schedule for completion in September 2015. User experiments are expected to start in Spring 2016.

Authors:
; ; ; ; ; ;  [1];  [1];  [2]
  1. National Synchrotron Light Source II, Brookhaven National Laboratory, Upton, New York (United States)
  2. (Germany)
Publication Date:
OSTI Identifier:
22608385
Resource Type:
Journal Article
Resource Relation:
Journal Name: AIP Conference Proceedings; Journal Volume: 1741; Journal Issue: 1; Conference: SRI2015: 12. international conference on synchrotron radiation instrumentation, New York, NY (United States), 6-10 Jul 2015; Other Information: (c) 2016 Author(s); Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
43 PARTICLE ACCELERATORS; ANIMAL TISSUES; BEAMS; BIOMEDICAL RADIOGRAPHY; BNL; FOCUSING; KEV RANGE; LENSES; MEMBRANES; MOLECULES; NSLS; STABILITY; SWITCHES; TIME RESOLUTION; X RADIATION; X-RAY DIFFRACTION

Citation Formats

DiFabio, Jonathan, Chodankar, Shirish, Pjerov, Sal, Jakoncic, Jean, Lucas, Michael, Graziano, Vito, Yang, Lin, E-mail: lyang@bnl.gov, Krywka, Christina, and On leave from Institut für Werkstoffforschung, Helmholtz-Zentrum Geesthacht, Hamburg. The life science x-ray scattering beamline at NSLS-II. United States: N. p., 2016. Web. doi:10.1063/1.4952872.
DiFabio, Jonathan, Chodankar, Shirish, Pjerov, Sal, Jakoncic, Jean, Lucas, Michael, Graziano, Vito, Yang, Lin, E-mail: lyang@bnl.gov, Krywka, Christina, & On leave from Institut für Werkstoffforschung, Helmholtz-Zentrum Geesthacht, Hamburg. The life science x-ray scattering beamline at NSLS-II. United States. doi:10.1063/1.4952872.
DiFabio, Jonathan, Chodankar, Shirish, Pjerov, Sal, Jakoncic, Jean, Lucas, Michael, Graziano, Vito, Yang, Lin, E-mail: lyang@bnl.gov, Krywka, Christina, and On leave from Institut für Werkstoffforschung, Helmholtz-Zentrum Geesthacht, Hamburg. Wed . "The life science x-ray scattering beamline at NSLS-II". United States. doi:10.1063/1.4952872.
@article{osti_22608385,
title = {The life science x-ray scattering beamline at NSLS-II},
author = {DiFabio, Jonathan and Chodankar, Shirish and Pjerov, Sal and Jakoncic, Jean and Lucas, Michael and Graziano, Vito and Yang, Lin, E-mail: lyang@bnl.gov and Krywka, Christina and On leave from Institut für Werkstoffforschung, Helmholtz-Zentrum Geesthacht, Hamburg},
abstractNote = {We report the current development status of the High Brightness X-ray Scattering for Life Sciences (or Life Science X-ray Scattering, LiX) beamline at the NSLS-II facility of Brookhaven National Laboratory. This instrument will operate in the x-ray energy range of 2.1-18 keV, provide variable beam sizes from 1 micron to ∼0.5 mm, and support user experiments in three scientific areas: (1) high-throughput solution scattering, in-line size exclusion chromatography and flow mixers-based time-resolved solution scattering of biological macro-molecules, (2) diffraction from single- and multi-layered lipid membranes, and (3) scattering-based scanning probe imaging of biological tissues. In order to satisfy the beam stability required for these experiments and to switch rapidly between different types of experiments, we have adopted a secondary source with refractive lenses for secondary focusing, a detector system consisting of three Pilatus detectors, and specialized experimental modules that can be quickly exchanged and each dedicated to a defined set of experiments. The construction of this beamline is on schedule for completion in September 2015. User experiments are expected to start in Spring 2016.},
doi = {10.1063/1.4952872},
journal = {AIP Conference Proceedings},
number = 1,
volume = 1741,
place = {United States},
year = {Wed Jul 27 00:00:00 EDT 2016},
month = {Wed Jul 27 00:00:00 EDT 2016}
}