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Title: The first experience of using {sup 99m}Tc-Al{sub 2}O{sub 3}-based radiopharmaceutical for the detection of sentinel lymph nodes in cervical cancer patients

Abstract

The purpose of the study was to evaluate the feasibility of using {sup 99m}Tc-Al{sub 2}O{sub 3}-based radiopharmaceutical, a novel molecular imaging agent for sentinel lymph node detection in patients with invasive cervical cancer. The study included 23 cervical cancer patients (T1aNxMx-T2bNxMx) treated at the Tomsk Cancer Research Institute. In the 18 hours before surgery, 80 MBq of the {sup 99m}Tc-Al{sub 2}O{sub 3} in peritumoral injected, followed by single-photon emission computed tomography (SPECT) of the pelvis and intraoperative SLN identification. Twenty-seven SLNs were detected by SPECT, and 34 SLNs were identified by intraoperative gamma probe. The total number of identified SLNs per patient ranged from 1 to 3 (the mean number of SLNs was 1.4 per patient). The most common site for SLN detection was the external iliac region (57.2%), followed by the internal iliac (14%), obturator (14%), presacral and retrosacral regions (14%), and the parametrial region (1%). Sensitivity in detecting SLNs was 100% for intraoperative SLN identification and 79% for SPECT image.

Authors:
; ; ; ;  [1];  [2];  [1];  [1];  [2]
  1. Tomsk Cancer Research Institute, Kooperativny Street 5, Tomsk, 634050 (Russian Federation)
  2. (Russian Federation)
Publication Date:
OSTI Identifier:
22608289
Resource Type:
Journal Article
Resource Relation:
Journal Name: AIP Conference Proceedings; Journal Volume: 1760; Journal Issue: 1; Conference: PC'16: International conference on physics of cancer: Interdisciplinary problems and clinical applications 2016, Tomsk (Russian Federation), 22-25 Mar 2016; Other Information: (c) 2016 Author(s); Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; ALUMINIUM OXIDES; BIOMEDICAL RADIOGRAPHY; DETECTION; LYMPH; LYMPH NODES; NEOPLASMS; PATIENTS; PHOTON EMISSION; PHOTONS; RADIOPHARMACEUTICALS; SENSITIVITY; SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY; SURGERY; TECHNETIUM 99

Citation Formats

Sinilkin, I. G., Chernov, V. I., Medvedeva, A. A., Zelchan, R. V., Chernyshova, A. L., National Research Tomsk Polytechnic University, Lenin Avenue 30, Tomsk, 634050, Lyapunov, A. Yu., E-mail: Lyapunov1720.90@mail.ru, Kolomiets, L. A., and Siberian State Medical University, Moskovsky Trakt 2, Tomsk, 634050. The first experience of using {sup 99m}Tc-Al{sub 2}O{sub 3}-based radiopharmaceutical for the detection of sentinel lymph nodes in cervical cancer patients. United States: N. p., 2016. Web. doi:10.1063/1.4960279.
Sinilkin, I. G., Chernov, V. I., Medvedeva, A. A., Zelchan, R. V., Chernyshova, A. L., National Research Tomsk Polytechnic University, Lenin Avenue 30, Tomsk, 634050, Lyapunov, A. Yu., E-mail: Lyapunov1720.90@mail.ru, Kolomiets, L. A., & Siberian State Medical University, Moskovsky Trakt 2, Tomsk, 634050. The first experience of using {sup 99m}Tc-Al{sub 2}O{sub 3}-based radiopharmaceutical for the detection of sentinel lymph nodes in cervical cancer patients. United States. doi:10.1063/1.4960279.
Sinilkin, I. G., Chernov, V. I., Medvedeva, A. A., Zelchan, R. V., Chernyshova, A. L., National Research Tomsk Polytechnic University, Lenin Avenue 30, Tomsk, 634050, Lyapunov, A. Yu., E-mail: Lyapunov1720.90@mail.ru, Kolomiets, L. A., and Siberian State Medical University, Moskovsky Trakt 2, Tomsk, 634050. Tue . "The first experience of using {sup 99m}Tc-Al{sub 2}O{sub 3}-based radiopharmaceutical for the detection of sentinel lymph nodes in cervical cancer patients". United States. doi:10.1063/1.4960279.
@article{osti_22608289,
title = {The first experience of using {sup 99m}Tc-Al{sub 2}O{sub 3}-based radiopharmaceutical for the detection of sentinel lymph nodes in cervical cancer patients},
author = {Sinilkin, I. G. and Chernov, V. I. and Medvedeva, A. A. and Zelchan, R. V. and Chernyshova, A. L. and National Research Tomsk Polytechnic University, Lenin Avenue 30, Tomsk, 634050 and Lyapunov, A. Yu., E-mail: Lyapunov1720.90@mail.ru and Kolomiets, L. A. and Siberian State Medical University, Moskovsky Trakt 2, Tomsk, 634050},
abstractNote = {The purpose of the study was to evaluate the feasibility of using {sup 99m}Tc-Al{sub 2}O{sub 3}-based radiopharmaceutical, a novel molecular imaging agent for sentinel lymph node detection in patients with invasive cervical cancer. The study included 23 cervical cancer patients (T1aNxMx-T2bNxMx) treated at the Tomsk Cancer Research Institute. In the 18 hours before surgery, 80 MBq of the {sup 99m}Tc-Al{sub 2}O{sub 3} in peritumoral injected, followed by single-photon emission computed tomography (SPECT) of the pelvis and intraoperative SLN identification. Twenty-seven SLNs were detected by SPECT, and 34 SLNs were identified by intraoperative gamma probe. The total number of identified SLNs per patient ranged from 1 to 3 (the mean number of SLNs was 1.4 per patient). The most common site for SLN detection was the external iliac region (57.2%), followed by the internal iliac (14%), obturator (14%), presacral and retrosacral regions (14%), and the parametrial region (1%). Sensitivity in detecting SLNs was 100% for intraoperative SLN identification and 79% for SPECT image.},
doi = {10.1063/1.4960279},
journal = {AIP Conference Proceedings},
number = 1,
volume = 1760,
place = {United States},
year = {Tue Aug 02 00:00:00 EDT 2016},
month = {Tue Aug 02 00:00:00 EDT 2016}
}