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Title: Concurrent thermochemoradiotherapy for brain high-grade glioma

Abstract

Despite the achievements in the current strategies for treatment, the prognosis in malignant glioma patients remains unsatisfactory. Hyperthermia is currently considered to be the most effective and universal modifier of radiotherapy and chemotherapy. Preliminary treatment outcomes for 28 patients with newly diagnosed (23) and recurrent (5) high-grade gliomas were presented. All the patients received multimodality treatment including surgery, thermoche-moradiotherapy followed by 4 cycles of adjuvant chemotherapy. All the patients endured thermochemoradiotherapy well. A complication, limited skin burn (II stage), was diagnosed in two cases and treated conservatively without treatment interruption. A month after thermochemoradiotherapy the results were as follows: complete regression was achieved in 4 cases, partial regression in 4 cases, stable disease in 14 cases and disease progression in 6 cases (one of them is pseudo-progression). After completing the adjuvant chemotherapy 2 more patients demonstrated complete response and 1 patient had disease progression. Introduction of local hyperthermia in multimodal therapy of malignant glioma does not impair the combined modality treatment tolerability of patients with malignant gliomas. A small number of studied patients and short follow-up time do not allow making reliable conclusions about the impact of local hyperthermia on the treatment outcomes; however, there is a tendency towards themore » increase in disease-free survival in the patients with newly diagnosed malignant gliomas.« less

Authors:
; ; ; ;  [1];  [1];  [2];  [1];  [2];  [3]
  1. Tomsk Cancer Research Institute, Tomsk, 634050 (Russian Federation)
  2. (Russian Federation)
  3. National Research Tomsk Polytechnic University, Tomsk, 634050 (Russian Federation)
Publication Date:
OSTI Identifier:
22608288
Resource Type:
Journal Article
Resource Relation:
Journal Name: AIP Conference Proceedings; Journal Volume: 1760; Journal Issue: 1; Conference: PC'16: International conference on physics of cancer: Interdisciplinary problems and clinical applications 2016, Tomsk (Russian Federation), 22-25 Mar 2016; Other Information: (c) 2016 Author(s); Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; BRAIN; CHEMOTHERAPY; DIAGNOSIS; GLIOMAS; HYPERTHERMIA; PATIENTS; RADIOTHERAPY; SKIN; SURGERY

Citation Formats

Ryabova, A. I., E-mail: ranigor@mail.ru, Novikov, V. A., Startseva, Zh. A., Bober, E. E., Frolova, I. G., Choinzonov, E. L., Siberian State Medical University, Tomsk, 634050, Gribova, O. V., National Research Tomsk Polytechnic University, Tomsk, 634050, and Baranova, A. V. Concurrent thermochemoradiotherapy for brain high-grade glioma. United States: N. p., 2016. Web. doi:10.1063/1.4960277.
Ryabova, A. I., E-mail: ranigor@mail.ru, Novikov, V. A., Startseva, Zh. A., Bober, E. E., Frolova, I. G., Choinzonov, E. L., Siberian State Medical University, Tomsk, 634050, Gribova, O. V., National Research Tomsk Polytechnic University, Tomsk, 634050, & Baranova, A. V. Concurrent thermochemoradiotherapy for brain high-grade glioma. United States. doi:10.1063/1.4960277.
Ryabova, A. I., E-mail: ranigor@mail.ru, Novikov, V. A., Startseva, Zh. A., Bober, E. E., Frolova, I. G., Choinzonov, E. L., Siberian State Medical University, Tomsk, 634050, Gribova, O. V., National Research Tomsk Polytechnic University, Tomsk, 634050, and Baranova, A. V. Tue . "Concurrent thermochemoradiotherapy for brain high-grade glioma". United States. doi:10.1063/1.4960277.
@article{osti_22608288,
title = {Concurrent thermochemoradiotherapy for brain high-grade glioma},
author = {Ryabova, A. I., E-mail: ranigor@mail.ru and Novikov, V. A. and Startseva, Zh. A. and Bober, E. E. and Frolova, I. G. and Choinzonov, E. L. and Siberian State Medical University, Tomsk, 634050 and Gribova, O. V. and National Research Tomsk Polytechnic University, Tomsk, 634050 and Baranova, A. V.},
abstractNote = {Despite the achievements in the current strategies for treatment, the prognosis in malignant glioma patients remains unsatisfactory. Hyperthermia is currently considered to be the most effective and universal modifier of radiotherapy and chemotherapy. Preliminary treatment outcomes for 28 patients with newly diagnosed (23) and recurrent (5) high-grade gliomas were presented. All the patients received multimodality treatment including surgery, thermoche-moradiotherapy followed by 4 cycles of adjuvant chemotherapy. All the patients endured thermochemoradiotherapy well. A complication, limited skin burn (II stage), was diagnosed in two cases and treated conservatively without treatment interruption. A month after thermochemoradiotherapy the results were as follows: complete regression was achieved in 4 cases, partial regression in 4 cases, stable disease in 14 cases and disease progression in 6 cases (one of them is pseudo-progression). After completing the adjuvant chemotherapy 2 more patients demonstrated complete response and 1 patient had disease progression. Introduction of local hyperthermia in multimodal therapy of malignant glioma does not impair the combined modality treatment tolerability of patients with malignant gliomas. A small number of studied patients and short follow-up time do not allow making reliable conclusions about the impact of local hyperthermia on the treatment outcomes; however, there is a tendency towards the increase in disease-free survival in the patients with newly diagnosed malignant gliomas.},
doi = {10.1063/1.4960277},
journal = {AIP Conference Proceedings},
number = 1,
volume = 1760,
place = {United States},
year = {Tue Aug 02 00:00:00 EDT 2016},
month = {Tue Aug 02 00:00:00 EDT 2016}
}