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Title: Characterization of the infrared spectra of serum from patients with multiple myeloma

Abstract

Multiple myeloma (MM) accounts for about 1% of all types of cancers. MM is characterized by the proliferation of a single clone of plasma cells, which may produce and secrete a homogeneous monoclonal immunoglobulin. The monoclonal immunoglobulin is commonly referred to as an M protein. The M protein acts as a serological “tumor” marker that is useful for diagnosis and disease monitoring. The electrophoretic pattern reveals the M-protein in 80% of MM patients as a single peak or localized band. In our study we applied a combination of high-resolution agarose gel protein electrophoresis (PEL), spectroscopic techniques and thermal analysis to identify the key differences in protein composition, protein structure and their thermal behavior for the samples obtained from the serum of MM patients and healthy donors.

Authors:
; ;  [1];  [2]; ;  [3]
  1. Saint Petersburg National Research University of Information Technologies, Mechanics and Optics, Kronverksky Pr., Saint Petersburg, 197101 (Russian Federation)
  2. Saint Petersburg State University, Universitetskaya Nab. 7/9, Saint Petersburg, 199034 (Russian Federation)
  3. Russian Scientific Research Institute of Hematology and Transfusiology, 2nd Sovetskaya Str. 16, Saint Petersburg, 191024 (Russian Federation)
Publication Date:
OSTI Identifier:
22608286
Resource Type:
Journal Article
Resource Relation:
Journal Name: AIP Conference Proceedings; Journal Volume: 1760; Journal Issue: 1; Conference: PC'16: International conference on physics of cancer: Interdisciplinary problems and clinical applications 2016, Tomsk (Russian Federation), 22-25 Mar 2016; Other Information: (c) 2016 Author(s); Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; DIAGNOSIS; ELECTROPHORESIS; IMMUNOGLOBULINS; INFRARED SPECTRA; NEOPLASMS; PATIENTS; PLASMA; PLASMA CELLS; PROLIFERATION; PROTEIN STRUCTURE; RESOLUTION; THERMAL ANALYSIS

Citation Formats

Plotnikova, L., E-mail: ljusja@mail.ru, Nosenko, T., Uspenskaya, M., E-mail: mv-uspenskaya@mail.ru, Polyanichko, A., Garifullin, A., and Voloshin, S. Characterization of the infrared spectra of serum from patients with multiple myeloma. United States: N. p., 2016. Web. doi:10.1063/1.4960271.
Plotnikova, L., E-mail: ljusja@mail.ru, Nosenko, T., Uspenskaya, M., E-mail: mv-uspenskaya@mail.ru, Polyanichko, A., Garifullin, A., & Voloshin, S. Characterization of the infrared spectra of serum from patients with multiple myeloma. United States. doi:10.1063/1.4960271.
Plotnikova, L., E-mail: ljusja@mail.ru, Nosenko, T., Uspenskaya, M., E-mail: mv-uspenskaya@mail.ru, Polyanichko, A., Garifullin, A., and Voloshin, S. 2016. "Characterization of the infrared spectra of serum from patients with multiple myeloma". United States. doi:10.1063/1.4960271.
@article{osti_22608286,
title = {Characterization of the infrared spectra of serum from patients with multiple myeloma},
author = {Plotnikova, L., E-mail: ljusja@mail.ru and Nosenko, T. and Uspenskaya, M., E-mail: mv-uspenskaya@mail.ru and Polyanichko, A. and Garifullin, A. and Voloshin, S.},
abstractNote = {Multiple myeloma (MM) accounts for about 1% of all types of cancers. MM is characterized by the proliferation of a single clone of plasma cells, which may produce and secrete a homogeneous monoclonal immunoglobulin. The monoclonal immunoglobulin is commonly referred to as an M protein. The M protein acts as a serological “tumor” marker that is useful for diagnosis and disease monitoring. The electrophoretic pattern reveals the M-protein in 80% of MM patients as a single peak or localized band. In our study we applied a combination of high-resolution agarose gel protein electrophoresis (PEL), spectroscopic techniques and thermal analysis to identify the key differences in protein composition, protein structure and their thermal behavior for the samples obtained from the serum of MM patients and healthy donors.},
doi = {10.1063/1.4960271},
journal = {AIP Conference Proceedings},
number = 1,
volume = 1760,
place = {United States},
year = 2016,
month = 8
}