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Title: Novel technologies and theoretical models in radiation therapy of cancer patients using 6.3 MeV fast neutrons produced by U-120 cyclotron

Abstract

The analysis of clinical use of neutron therapy with 6 MeV fast neutrons compared to conventional radiation therapy was carried out. The experience of using neutron and mixed neutron and photon therapy in patients with different radio-resistant malignant tumors shows the necessity of further studies and development of the novel approaches to densely-ionizing radiation. The results of dosimetry and radiobiological studies have been the basis for planning clinical programs for neutron therapy. Clinical trials over the past 30 years have shown that neutron therapy successfully destroys radio-resistant cancers, including salivary gland tumors, adenoidcystic carcinoma, inoperable sarcomas, locally advanced head and neck tumors, and locally advanced prostate cancer. Radiation therapy with 6.3 MeV fast neutrons used alone and in combination with photon therapy resulted in improved long-term treatment outcomes in patients with radio-resistant malignant tumors.

Authors:
;  [1]; ; ;  [1];  [2]
  1. Tomsk Cancer Research Institute, Kooperativny Street 5, Tomsk, 634050 (Russian Federation)
  2. (Russian Federation)
Publication Date:
OSTI Identifier:
22608284
Resource Type:
Journal Article
Resource Relation:
Journal Name: AIP Conference Proceedings; Journal Volume: 1760; Journal Issue: 1; Conference: PC'16: International conference on physics of cancer: Interdisciplinary problems and clinical applications 2016, Tomsk (Russian Federation), 22-25 Mar 2016; Other Information: (c) 2016 Author(s); Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; CARCINOMAS; CLINICAL TRIALS; COMPARATIVE EVALUATIONS; CYCLOTRONS; DOSIMETRY; FAST NEUTRONS; HEAD; IONIZING RADIATIONS; MEV RANGE 01-10; NECK; NEUTRON THERAPY; PATIENTS; PHOTONS; PLANNING; PROSTATE; SALIVARY GLANDS; SARCOMAS

Citation Formats

Musabaeva, L. I., E-mail: musabaevaLI@oncology.tomsk.ru, Lisin, V. A., E-mail: Lisin@oncology.tomsk.ru, Startseva, Zh. A., E-mail: zhanna.alex@rambler.ru, Gribova, O. V., E-mail: gribova79@mail.ru, Velikaya, V. V., E-mail: viktoria.v.v@inbox.ru, and National Research Tomsk Polytechnic University, Lenin Avenue 30, Tomsk, 634050. Novel technologies and theoretical models in radiation therapy of cancer patients using 6.3 MeV fast neutrons produced by U-120 cyclotron. United States: N. p., 2016. Web. doi:10.1063/1.4960269.
Musabaeva, L. I., E-mail: musabaevaLI@oncology.tomsk.ru, Lisin, V. A., E-mail: Lisin@oncology.tomsk.ru, Startseva, Zh. A., E-mail: zhanna.alex@rambler.ru, Gribova, O. V., E-mail: gribova79@mail.ru, Velikaya, V. V., E-mail: viktoria.v.v@inbox.ru, & National Research Tomsk Polytechnic University, Lenin Avenue 30, Tomsk, 634050. Novel technologies and theoretical models in radiation therapy of cancer patients using 6.3 MeV fast neutrons produced by U-120 cyclotron. United States. doi:10.1063/1.4960269.
Musabaeva, L. I., E-mail: musabaevaLI@oncology.tomsk.ru, Lisin, V. A., E-mail: Lisin@oncology.tomsk.ru, Startseva, Zh. A., E-mail: zhanna.alex@rambler.ru, Gribova, O. V., E-mail: gribova79@mail.ru, Velikaya, V. V., E-mail: viktoria.v.v@inbox.ru, and National Research Tomsk Polytechnic University, Lenin Avenue 30, Tomsk, 634050. Tue . "Novel technologies and theoretical models in radiation therapy of cancer patients using 6.3 MeV fast neutrons produced by U-120 cyclotron". United States. doi:10.1063/1.4960269.
@article{osti_22608284,
title = {Novel technologies and theoretical models in radiation therapy of cancer patients using 6.3 MeV fast neutrons produced by U-120 cyclotron},
author = {Musabaeva, L. I., E-mail: musabaevaLI@oncology.tomsk.ru and Lisin, V. A., E-mail: Lisin@oncology.tomsk.ru and Startseva, Zh. A., E-mail: zhanna.alex@rambler.ru and Gribova, O. V., E-mail: gribova79@mail.ru and Velikaya, V. V., E-mail: viktoria.v.v@inbox.ru and National Research Tomsk Polytechnic University, Lenin Avenue 30, Tomsk, 634050},
abstractNote = {The analysis of clinical use of neutron therapy with 6 MeV fast neutrons compared to conventional radiation therapy was carried out. The experience of using neutron and mixed neutron and photon therapy in patients with different radio-resistant malignant tumors shows the necessity of further studies and development of the novel approaches to densely-ionizing radiation. The results of dosimetry and radiobiological studies have been the basis for planning clinical programs for neutron therapy. Clinical trials over the past 30 years have shown that neutron therapy successfully destroys radio-resistant cancers, including salivary gland tumors, adenoidcystic carcinoma, inoperable sarcomas, locally advanced head and neck tumors, and locally advanced prostate cancer. Radiation therapy with 6.3 MeV fast neutrons used alone and in combination with photon therapy resulted in improved long-term treatment outcomes in patients with radio-resistant malignant tumors.},
doi = {10.1063/1.4960269},
journal = {AIP Conference Proceedings},
number = 1,
volume = 1760,
place = {United States},
year = {Tue Aug 02 00:00:00 EDT 2016},
month = {Tue Aug 02 00:00:00 EDT 2016}
}