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Title: Lung scintigraphy in differential diagnosis of peripheral lung cancer and community-acquired pneumonia

Abstract

Ventilation/perfusion lung scintigraphy was performed in 39 patients with verified diagnosis of community-acquired pneumonia (CAP) and in 14 patients with peripheral lung cancer. Ventilation/perfusion ratio, apical-basal gradients of ventilation (U/L(V)) and lung perfusion (U/L(P)), and alveolar capillary permeability of radionuclide aerosol were determined based on scintigraphy data. The study demonstrated that main signs of CAP were increases in ventilation/perfusion ratio, perfusion and ventilation gradient on a side of the diseased lung, and two-side increase in alveolar capillary permeability rate for radionuclide aerosol. Unlike this, scintigraphic signs of peripheral lung cancer comprise an increase in ventilation/perfusion ratio over 1.0 on a side of the diseased lung with its simultaneous decrease on a contralateral side, normal values of perfusion and ventilation gradients of both lungs, and delayed alveolar capillary clearance in the diseased lung compared with the intact lung.

Authors:
 [1]; ; ;  [1];  [2]
  1. Research Institute of Cardiology, Kievskaya Street 111a, Tomsk, 634012 (Russian Federation)
  2. (Russian Federation)
Publication Date:
OSTI Identifier:
22608280
Resource Type:
Journal Article
Resource Relation:
Journal Name: AIP Conference Proceedings; Journal Volume: 1760; Journal Issue: 1; Conference: PC'16: International conference on physics of cancer: Interdisciplinary problems and clinical applications 2016, Tomsk (Russian Federation), 22-25 Mar 2016; Other Information: (c) 2016 Author(s); Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; AEROSOLS; CAPILLARIES; CLEARANCE; COMPARATIVE EVALUATIONS; DIAGNOSIS; LUNGS; NEOPLASMS; PATIENTS; PERMEABILITY; PNEUMONIA; SCINTISCANNING

Citation Formats

Krivonogov, Nikolay G., E-mail: kng@cardio-tomsk.ru, Efimova, Nataliya Y., E-mail: efimova@cardio-tomsk.ru, Zavadovsky, Konstantin W., Lishmanov, Yuri B., and Tomsk Polytechnic University, Lenin Avenue 30, Tomsk, 634050. Lung scintigraphy in differential diagnosis of peripheral lung cancer and community-acquired pneumonia. United States: N. p., 2016. Web. doi:10.1063/1.4960256.
Krivonogov, Nikolay G., E-mail: kng@cardio-tomsk.ru, Efimova, Nataliya Y., E-mail: efimova@cardio-tomsk.ru, Zavadovsky, Konstantin W., Lishmanov, Yuri B., & Tomsk Polytechnic University, Lenin Avenue 30, Tomsk, 634050. Lung scintigraphy in differential diagnosis of peripheral lung cancer and community-acquired pneumonia. United States. doi:10.1063/1.4960256.
Krivonogov, Nikolay G., E-mail: kng@cardio-tomsk.ru, Efimova, Nataliya Y., E-mail: efimova@cardio-tomsk.ru, Zavadovsky, Konstantin W., Lishmanov, Yuri B., and Tomsk Polytechnic University, Lenin Avenue 30, Tomsk, 634050. 2016. "Lung scintigraphy in differential diagnosis of peripheral lung cancer and community-acquired pneumonia". United States. doi:10.1063/1.4960256.
@article{osti_22608280,
title = {Lung scintigraphy in differential diagnosis of peripheral lung cancer and community-acquired pneumonia},
author = {Krivonogov, Nikolay G., E-mail: kng@cardio-tomsk.ru and Efimova, Nataliya Y., E-mail: efimova@cardio-tomsk.ru and Zavadovsky, Konstantin W. and Lishmanov, Yuri B. and Tomsk Polytechnic University, Lenin Avenue 30, Tomsk, 634050},
abstractNote = {Ventilation/perfusion lung scintigraphy was performed in 39 patients with verified diagnosis of community-acquired pneumonia (CAP) and in 14 patients with peripheral lung cancer. Ventilation/perfusion ratio, apical-basal gradients of ventilation (U/L(V)) and lung perfusion (U/L(P)), and alveolar capillary permeability of radionuclide aerosol were determined based on scintigraphy data. The study demonstrated that main signs of CAP were increases in ventilation/perfusion ratio, perfusion and ventilation gradient on a side of the diseased lung, and two-side increase in alveolar capillary permeability rate for radionuclide aerosol. Unlike this, scintigraphic signs of peripheral lung cancer comprise an increase in ventilation/perfusion ratio over 1.0 on a side of the diseased lung with its simultaneous decrease on a contralateral side, normal values of perfusion and ventilation gradients of both lungs, and delayed alveolar capillary clearance in the diseased lung compared with the intact lung.},
doi = {10.1063/1.4960256},
journal = {AIP Conference Proceedings},
number = 1,
volume = 1760,
place = {United States},
year = 2016,
month = 8
}
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