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Title: Experimental study of {sup 99m}Tc-aluminum oxide use for sentinel lymph nodes detection

Abstract

The purpose of the study was a comparative research in the possibility of using the radiopharmaceuticals {sup 99m}Tc-Al{sub 2}O{sub 3} and {sup 99m}Tc-Nanocis for visualizing sentinel lymph nodes. The measurement of the sizes of {sup 99m}Tc-Al{sub 2}O{sub 3} and {sup 99m}Tc-Nanocis colloidal particles was performed in seven series of radiopharmaceuticals. The pharmacokinetics of {sup 99m}Tc-Al{sub 2}O{sub 3} and {sup 99m}Tc-Nanocis was researched on 50 white male rats. The possibility of the use of {sup 99m}Tc-Al{sub 2}O{sub 3} and {sup 99m}Tc-Nanocis for lymphoscintigraphy was studied in the experiments on 12 white male rats. The average dynamic diameter of the sol particle was 52–77 nm for {sup 99m}Tc-Al{sub 2}O{sub 3} and 16.7–24.5 nm for {sup 99m}Tc-Nanocis. Radiopharmaceuticals accumulated in the inguinal lymph node in 1 hour after administration; the average uptake of {sup 99}mTc-Al{sub 2}O{sub 3} was 8.6% in it, and the accumulation of {sup 99m}Tc-Nanocis was significantly lower—1.8% (p < 0.05). In all study points the average uptake of {sup 99m}Tc-Al{sub 2}O{sub 3} in the lymph node was significantly higher than {sup 99m}Tc-Nanocis accumulation. The results of dynamic scintigraphic studies in rats showed that {sup 99m}Tc-Al{sub 2}O{sub 3} and {sup 99m}Tc-Nanocis actively accumulated into the lymphatic system. By using {sup 99m}Tc-Al{submore » 2}O{sub 3} inguinal lymph node was determined in 5 minutes after injection and clearly visualized in all the animals in the 15th minute, when the accumulation became more than 1% of the administered dose. Further observation indicated that the {sup 99m}Tc-Al{sub 2}O{sub 3} accumulation reached a plateau in a lymph node (average 10.5%) during 2-hour study and then its accumulation remained practically at the same level, slightly increasing to 12% in 24 hours. In case of {sup 99m}Tc-Nanocis inguinal lymph node was visualized in all animals for 15 min when it was accumulated on the average 1.03% of the administered dose. Plateau of {sup 99m}Tc-Nanocis accumulation in the lymph node (average 2.05%) occurred after 2 hours of the study and remained almost on the same level (in average 2.3%) for 24 hours. Thus, the experimental study of a new domestic radiopharmaceutical showed that the {sup 99m}Tc-Al{sub 2}O{sub 3} accumulates actively in the lymph nodes several times as compared to the imported analogue and its practical application will facilitate intraoperative identification of sentinel lymph nodes.« less

Authors:
; ; ;  [1];  [2];  [1]; ; ;  [3]
  1. Tomsk Cancer Research Institute, Kooperativny Street 5, Tomsk, 634050 (Russian Federation)
  2. (Russian Federation)
  3. Tomsk Polytechnic University, Lenin Avenue 30, Tomsk, 634050 (Russian Federation)
Publication Date:
OSTI Identifier:
22608271
Resource Type:
Journal Article
Resource Relation:
Journal Name: AIP Conference Proceedings; Journal Volume: 1760; Journal Issue: 1; Conference: PC'16: International conference on physics of cancer: Interdisciplinary problems and clinical applications 2016, Tomsk (Russian Federation), 22-25 Mar 2016; Other Information: (c) 2016 Author(s); Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; ALUMINIUM; ALUMINIUM OXIDES; COMPARATIVE EVALUATIONS; DETECTION; INJECTION; LYMPH; LYMPH NODES; MALES; RADIATION DOSES; RADIOPHARMACEUTICALS; RATS; SCINTISCANNING; TECHNETIUM 99

Citation Formats

Chernov, V. I., E-mail: Chernov@oncology.tomsk.ru, Sinilkin, I. G., Zelchan, R. V., Medvedeva, A. A., Tomsk Polytechnic University, Lenin Avenue 30, Tomsk, 634050, Lyapunov, A. Yu., E-mail: Lyapunov1720.90@mail.ru, Bragina, O. D., Varlamova, N. V., and Skuridin, V. S. Experimental study of {sup 99m}Tc-aluminum oxide use for sentinel lymph nodes detection. United States: N. p., 2016. Web. doi:10.1063/1.4960231.
Chernov, V. I., E-mail: Chernov@oncology.tomsk.ru, Sinilkin, I. G., Zelchan, R. V., Medvedeva, A. A., Tomsk Polytechnic University, Lenin Avenue 30, Tomsk, 634050, Lyapunov, A. Yu., E-mail: Lyapunov1720.90@mail.ru, Bragina, O. D., Varlamova, N. V., & Skuridin, V. S. Experimental study of {sup 99m}Tc-aluminum oxide use for sentinel lymph nodes detection. United States. doi:10.1063/1.4960231.
Chernov, V. I., E-mail: Chernov@oncology.tomsk.ru, Sinilkin, I. G., Zelchan, R. V., Medvedeva, A. A., Tomsk Polytechnic University, Lenin Avenue 30, Tomsk, 634050, Lyapunov, A. Yu., E-mail: Lyapunov1720.90@mail.ru, Bragina, O. D., Varlamova, N. V., and Skuridin, V. S. Tue . "Experimental study of {sup 99m}Tc-aluminum oxide use for sentinel lymph nodes detection". United States. doi:10.1063/1.4960231.
@article{osti_22608271,
title = {Experimental study of {sup 99m}Tc-aluminum oxide use for sentinel lymph nodes detection},
author = {Chernov, V. I., E-mail: Chernov@oncology.tomsk.ru and Sinilkin, I. G. and Zelchan, R. V. and Medvedeva, A. A. and Tomsk Polytechnic University, Lenin Avenue 30, Tomsk, 634050 and Lyapunov, A. Yu., E-mail: Lyapunov1720.90@mail.ru and Bragina, O. D. and Varlamova, N. V. and Skuridin, V. S.},
abstractNote = {The purpose of the study was a comparative research in the possibility of using the radiopharmaceuticals {sup 99m}Tc-Al{sub 2}O{sub 3} and {sup 99m}Tc-Nanocis for visualizing sentinel lymph nodes. The measurement of the sizes of {sup 99m}Tc-Al{sub 2}O{sub 3} and {sup 99m}Tc-Nanocis colloidal particles was performed in seven series of radiopharmaceuticals. The pharmacokinetics of {sup 99m}Tc-Al{sub 2}O{sub 3} and {sup 99m}Tc-Nanocis was researched on 50 white male rats. The possibility of the use of {sup 99m}Tc-Al{sub 2}O{sub 3} and {sup 99m}Tc-Nanocis for lymphoscintigraphy was studied in the experiments on 12 white male rats. The average dynamic diameter of the sol particle was 52–77 nm for {sup 99m}Tc-Al{sub 2}O{sub 3} and 16.7–24.5 nm for {sup 99m}Tc-Nanocis. Radiopharmaceuticals accumulated in the inguinal lymph node in 1 hour after administration; the average uptake of {sup 99}mTc-Al{sub 2}O{sub 3} was 8.6% in it, and the accumulation of {sup 99m}Tc-Nanocis was significantly lower—1.8% (p < 0.05). In all study points the average uptake of {sup 99m}Tc-Al{sub 2}O{sub 3} in the lymph node was significantly higher than {sup 99m}Tc-Nanocis accumulation. The results of dynamic scintigraphic studies in rats showed that {sup 99m}Tc-Al{sub 2}O{sub 3} and {sup 99m}Tc-Nanocis actively accumulated into the lymphatic system. By using {sup 99m}Tc-Al{sub 2}O{sub 3} inguinal lymph node was determined in 5 minutes after injection and clearly visualized in all the animals in the 15th minute, when the accumulation became more than 1% of the administered dose. Further observation indicated that the {sup 99m}Tc-Al{sub 2}O{sub 3} accumulation reached a plateau in a lymph node (average 10.5%) during 2-hour study and then its accumulation remained practically at the same level, slightly increasing to 12% in 24 hours. In case of {sup 99m}Tc-Nanocis inguinal lymph node was visualized in all animals for 15 min when it was accumulated on the average 1.03% of the administered dose. Plateau of {sup 99m}Tc-Nanocis accumulation in the lymph node (average 2.05%) occurred after 2 hours of the study and remained almost on the same level (in average 2.3%) for 24 hours. Thus, the experimental study of a new domestic radiopharmaceutical showed that the {sup 99m}Tc-Al{sub 2}O{sub 3} accumulates actively in the lymph nodes several times as compared to the imported analogue and its practical application will facilitate intraoperative identification of sentinel lymph nodes.},
doi = {10.1063/1.4960231},
journal = {AIP Conference Proceedings},
number = 1,
volume = 1760,
place = {United States},
year = {Tue Aug 02 00:00:00 EDT 2016},
month = {Tue Aug 02 00:00:00 EDT 2016}
}