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Title: Lanthanum-silicon-substituted hydroxyapatite: Mechanochemical synthesis and prospects for medical applications

Abstract

The paper presents the results of mechanochemical synthesis of hydroxyapatite (HAP) with simultaneous substitutions of lanthanum (La{sup 3+}) for calcium ions and silicate ((SiO{sub 4}){sup 4−}-group) for the phosphate group with the substituent concentrations in the range 0.2–2.0 mol per HAP mol. The use of Si-substituted HAP as a coating material promotes accelerated osteosynthesis and osteointegration of implants into the bone tissue. The replacement of calcium ions by La{sup 3+} in the HAP structure plays an antimicrobial role preventing inflammatory processes. Annealing-induced variations in the lattice parameters of synthesized samples indicate the substituent incorporation into the HAP structure. It is known that complex compounds with lanthanides are used for cancer chemotherapy. In particular, La plays a key role in the course of treatment of injured defects of bone tissue. In addition, La-substituted HAP can be used for filling bone defects and coating implants in postoperational areas affected by bone cancer.

Authors:
; ;  [1]; ;  [2]
  1. Institute of Solid State Chemistry and Mechanochemistry SB RAS, Kutateladze Street 18, Novosibirsk, 630128 (Russian Federation)
  2. Institute of Strength Physics and Materials Science SB RAS, Academicheskii Pr. 2/4, Tomsk, 634055 (Russian Federation)
Publication Date:
OSTI Identifier:
22608269
Resource Type:
Journal Article
Resource Relation:
Journal Name: AIP Conference Proceedings; Journal Volume: 1760; Journal Issue: 1; Conference: PC'16: International conference on physics of cancer: Interdisciplinary problems and clinical applications 2016, Tomsk (Russian Federation), 22-25 Mar 2016; Other Information: (c) 2016 Author(s); Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
37 INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY; APATITES; BONE TISSUES; CALCIUM; CALCIUM IONS; CHEMOTHERAPY; DEFECTS; IMPLANTS; INFLAMMATION; LANTHANUM; LANTHANUM IONS; LATTICE PARAMETERS; NEOPLASMS; PHOSPHATES; SILICATES; SILICON; SILICON OXIDES; SKELETON; SYNTHESIS

Citation Formats

Chaikina, M. V., E-mail: chaikinam@solid.nsc.ru, Bulina, N. V., E-mail: bulina@solid.nsc.ru, Prosanov, I. Yu., E-mail: prosanov@mail.ru, Komarova, E. G., E-mail: katerina@ispms.tsc.ru, and Sharkeev, Yu. P., E-mail: sharkeev@ispms.tsc.ru. Lanthanum-silicon-substituted hydroxyapatite: Mechanochemical synthesis and prospects for medical applications. United States: N. p., 2016. Web. doi:10.1063/1.4960228.
Chaikina, M. V., E-mail: chaikinam@solid.nsc.ru, Bulina, N. V., E-mail: bulina@solid.nsc.ru, Prosanov, I. Yu., E-mail: prosanov@mail.ru, Komarova, E. G., E-mail: katerina@ispms.tsc.ru, & Sharkeev, Yu. P., E-mail: sharkeev@ispms.tsc.ru. Lanthanum-silicon-substituted hydroxyapatite: Mechanochemical synthesis and prospects for medical applications. United States. doi:10.1063/1.4960228.
Chaikina, M. V., E-mail: chaikinam@solid.nsc.ru, Bulina, N. V., E-mail: bulina@solid.nsc.ru, Prosanov, I. Yu., E-mail: prosanov@mail.ru, Komarova, E. G., E-mail: katerina@ispms.tsc.ru, and Sharkeev, Yu. P., E-mail: sharkeev@ispms.tsc.ru. Tue . "Lanthanum-silicon-substituted hydroxyapatite: Mechanochemical synthesis and prospects for medical applications". United States. doi:10.1063/1.4960228.
@article{osti_22608269,
title = {Lanthanum-silicon-substituted hydroxyapatite: Mechanochemical synthesis and prospects for medical applications},
author = {Chaikina, M. V., E-mail: chaikinam@solid.nsc.ru and Bulina, N. V., E-mail: bulina@solid.nsc.ru and Prosanov, I. Yu., E-mail: prosanov@mail.ru and Komarova, E. G., E-mail: katerina@ispms.tsc.ru and Sharkeev, Yu. P., E-mail: sharkeev@ispms.tsc.ru},
abstractNote = {The paper presents the results of mechanochemical synthesis of hydroxyapatite (HAP) with simultaneous substitutions of lanthanum (La{sup 3+}) for calcium ions and silicate ((SiO{sub 4}){sup 4−}-group) for the phosphate group with the substituent concentrations in the range 0.2–2.0 mol per HAP mol. The use of Si-substituted HAP as a coating material promotes accelerated osteosynthesis and osteointegration of implants into the bone tissue. The replacement of calcium ions by La{sup 3+} in the HAP structure plays an antimicrobial role preventing inflammatory processes. Annealing-induced variations in the lattice parameters of synthesized samples indicate the substituent incorporation into the HAP structure. It is known that complex compounds with lanthanides are used for cancer chemotherapy. In particular, La plays a key role in the course of treatment of injured defects of bone tissue. In addition, La-substituted HAP can be used for filling bone defects and coating implants in postoperational areas affected by bone cancer.},
doi = {10.1063/1.4960228},
journal = {AIP Conference Proceedings},
number = 1,
volume = 1760,
place = {United States},
year = {Tue Aug 02 00:00:00 EDT 2016},
month = {Tue Aug 02 00:00:00 EDT 2016}
}