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Title: Lanthanum-silicon-substituted hydroxyapatite: Mechanochemical synthesis and prospects for medical applications

Abstract

The paper presents the results of mechanochemical synthesis of hydroxyapatite (HAP) with simultaneous substitutions of lanthanum (La{sup 3+}) for calcium ions and silicate ((SiO{sub 4}){sup 4−}-group) for the phosphate group with the substituent concentrations in the range 0.2–2.0 mol per HAP mol. The use of Si-substituted HAP as a coating material promotes accelerated osteosynthesis and osteointegration of implants into the bone tissue. The replacement of calcium ions by La{sup 3+} in the HAP structure plays an antimicrobial role preventing inflammatory processes. Annealing-induced variations in the lattice parameters of synthesized samples indicate the substituent incorporation into the HAP structure. It is known that complex compounds with lanthanides are used for cancer chemotherapy. In particular, La plays a key role in the course of treatment of injured defects of bone tissue. In addition, La-substituted HAP can be used for filling bone defects and coating implants in postoperational areas affected by bone cancer.

Authors:
; ;  [1]; ;  [2]
  1. Institute of Solid State Chemistry and Mechanochemistry SB RAS, Kutateladze Street 18, Novosibirsk, 630128 (Russian Federation)
  2. Institute of Strength Physics and Materials Science SB RAS, Academicheskii Pr. 2/4, Tomsk, 634055 (Russian Federation)
Publication Date:
OSTI Identifier:
22608269
Resource Type:
Journal Article
Resource Relation:
Journal Name: AIP Conference Proceedings; Journal Volume: 1760; Journal Issue: 1; Conference: PC'16: International conference on physics of cancer: Interdisciplinary problems and clinical applications 2016, Tomsk (Russian Federation), 22-25 Mar 2016; Other Information: (c) 2016 Author(s); Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
37 INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY; APATITES; BONE TISSUES; CALCIUM; CALCIUM IONS; CHEMOTHERAPY; DEFECTS; IMPLANTS; INFLAMMATION; LANTHANUM; LANTHANUM IONS; LATTICE PARAMETERS; NEOPLASMS; PHOSPHATES; SILICATES; SILICON; SILICON OXIDES; SKELETON; SYNTHESIS

Citation Formats

Chaikina, M. V., E-mail: chaikinam@solid.nsc.ru, Bulina, N. V., E-mail: bulina@solid.nsc.ru, Prosanov, I. Yu., E-mail: prosanov@mail.ru, Komarova, E. G., E-mail: katerina@ispms.tsc.ru, and Sharkeev, Yu. P., E-mail: sharkeev@ispms.tsc.ru. Lanthanum-silicon-substituted hydroxyapatite: Mechanochemical synthesis and prospects for medical applications. United States: N. p., 2016. Web. doi:10.1063/1.4960228.
Chaikina, M. V., E-mail: chaikinam@solid.nsc.ru, Bulina, N. V., E-mail: bulina@solid.nsc.ru, Prosanov, I. Yu., E-mail: prosanov@mail.ru, Komarova, E. G., E-mail: katerina@ispms.tsc.ru, & Sharkeev, Yu. P., E-mail: sharkeev@ispms.tsc.ru. Lanthanum-silicon-substituted hydroxyapatite: Mechanochemical synthesis and prospects for medical applications. United States. doi:10.1063/1.4960228.
Chaikina, M. V., E-mail: chaikinam@solid.nsc.ru, Bulina, N. V., E-mail: bulina@solid.nsc.ru, Prosanov, I. Yu., E-mail: prosanov@mail.ru, Komarova, E. G., E-mail: katerina@ispms.tsc.ru, and Sharkeev, Yu. P., E-mail: sharkeev@ispms.tsc.ru. 2016. "Lanthanum-silicon-substituted hydroxyapatite: Mechanochemical synthesis and prospects for medical applications". United States. doi:10.1063/1.4960228.
@article{osti_22608269,
title = {Lanthanum-silicon-substituted hydroxyapatite: Mechanochemical synthesis and prospects for medical applications},
author = {Chaikina, M. V., E-mail: chaikinam@solid.nsc.ru and Bulina, N. V., E-mail: bulina@solid.nsc.ru and Prosanov, I. Yu., E-mail: prosanov@mail.ru and Komarova, E. G., E-mail: katerina@ispms.tsc.ru and Sharkeev, Yu. P., E-mail: sharkeev@ispms.tsc.ru},
abstractNote = {The paper presents the results of mechanochemical synthesis of hydroxyapatite (HAP) with simultaneous substitutions of lanthanum (La{sup 3+}) for calcium ions and silicate ((SiO{sub 4}){sup 4−}-group) for the phosphate group with the substituent concentrations in the range 0.2–2.0 mol per HAP mol. The use of Si-substituted HAP as a coating material promotes accelerated osteosynthesis and osteointegration of implants into the bone tissue. The replacement of calcium ions by La{sup 3+} in the HAP structure plays an antimicrobial role preventing inflammatory processes. Annealing-induced variations in the lattice parameters of synthesized samples indicate the substituent incorporation into the HAP structure. It is known that complex compounds with lanthanides are used for cancer chemotherapy. In particular, La plays a key role in the course of treatment of injured defects of bone tissue. In addition, La-substituted HAP can be used for filling bone defects and coating implants in postoperational areas affected by bone cancer.},
doi = {10.1063/1.4960228},
journal = {AIP Conference Proceedings},
number = 1,
volume = 1760,
place = {United States},
year = 2016,
month = 8
}
  • Fluoridated hydroxyapatite (FHAp) was successfully synthesized from the starting materials of CaCO{sub 3}, CaHPO{sub 4}.2H{sub 2}O, and CaF{sub 2} via a mechanochemical-hydrothermal route. X-ray diffraction, infrared spectroscopy, surface area measurements, and scanning electron microscopy identified the resultant powders as FHAp nanocrystals with the specific surface areas of up to 114.72 m{sup 2}/g. The mechanism study revealed that under such mechanochemical-hydrothermal conditions the formation reactions of FHAp were completed in two stages. The starting materials firstly reacted into a poorly crystallized calcium-deficient apatite and the complete incorporation of fluoride ions into apatite occurred in the second stage.
  • The present paper investigates the preparation of magnesium (Mg) substituted biphasic mixtures of different hydroxyapatite (HAP)/{beta}-tricalcium phosphate ({beta}-TCP) ratios through aqueous precipitation method. The concentrations of added magnesium (Mg) were varied with the calcium in order to obtain constant (Ca+Mg)/P ratios of 1.67 ranging from 1.62+0.05, 1.58+0.09 and 1.54+0.13, respectively. The as prepared powders were calcined at different temperatures to study the phase behaviour and thermal stability. The powders were characterized by the following analytical techniques: TG-DTA, X-ray diffraction and FT-IR. The results have shown that substitution of Mg in the calcium-deficient apatites resulted in the formation of biphasic mixturesmore » of different HAP/{beta}-TCP ratios after heating above 700 deg. C. The ratios of the formation of phase mixtures were dependent on the calcium deficiency in the apatites with the higher deficiency having the strongest impact on the increased formation of {beta}-TCP and the substituted Mg was found to stabilize the {beta}-TCP phase. - Graphical abstract: Role of Mg in the behaviour of calcium-deficient apatites during calcination to form biphasic mixtures.« less
  • Synthetic hydroxyapatites incorporating small amounts of Si have shown improved biological performances in terms of enhanced bone apposition, bone in-growth and cell-mediated degradation. This paper reports a systematic investigation on Si-substituted hydroxyapatite (Si 1.40 wt%) nanopowders produced following two different conventional wet methodologies: (a) precipitation of Ca(NO{sub 3}){sub 2}.4H{sub 2}O and (b) titration of Ca(OH){sub 2}. The influence of the synthesis process on composition, thermal behaviour and sinterability of the resulting nanopowders is studied. Samples were characterised by electron microscopy, induced coupled plasma atomic emission spectroscopy, thermal analysis, infrared spectroscopy, N{sub 2} adsorption measurements, X-ray diffraction and dilatometry. Semicrystalline Si-substitutedmore » hydroxyapatite powders made up of needle-like nanoparticles were obtained, the specific surface area ranged between 84 and 110 m{sup 2}/g. Pure and Si-substituted hydroxyapatite nanopowders derived from Ca(NO{sub 3}){sub 2}.4H{sub 2}O decomposed around 1000 deg. C. Si-substituted hydroxyapatite nanopowders obtained from Ca(OH){sub 2} were thermally stable up to 1200 deg. C and showed a distinct decreased thermal stability with respect to the homologous pure sample. Si-substituted hydroxyapatites exhibited higher sintering temperature and increased total shrinkage with respect to pure powders. Nanostructured dense ceramics were obtained by sintering at 1100 deg. C Si-substituted hydroxyapatites derived from Ca(OH){sub 2}.« less
  • Graphene oxide (GO) and hydroxyapatite (HAp) are frequently used as reinforcements in polymers to improve mechanical and biological properties. In this work, novel porous hybrid nanocomposites consisting of GO, HAp, and sodium alginate (SA) have been prepared by facile solution mixing and freeze drying in an attempt to obtain a scaffold with desirable mechanical and biological properties. The as-prepared porous GO/HAp/SA hybrid nanocomposites were characterized by SEM, XRD, FTIR, TGA, and mechanical testing. In addition, preliminary cell behavior was assessed by CCK8 assay. It is found that the GO/HAp/SA nanocomposites show improved compressive strength and modulus over neat SA andmore » HAp/SA nanocomposites. CCK8 results reveal that the GO/HAp/SA nanocomposites show enhanced cell proliferation over neat SA and GO/SA nanocomposite. It has been demonstrated that GO/HAp20/SA holds promise in bone tissue engineering. - Graphical abstract: Display Omitted - Highlights: • Graphene oxide (GO), hydroxyapatite (HAp), and alginate (SA) nanocomposites were fabricated. • The novel porous composites were prepared by solution mixture and freeze drying. • The GO/HAp/SA had porous structure with porosity > 85% and pore size > 150 μm. • The GO/HAp/SA exhibited improved mechanical properties over HAp/SA counterparts. • The GO/HAp/SA showed enhanced cell proliferation over GO/SA counterparts.« less
  • LaAlO[sub 3] was chemically modified in order to ascertain the effects of substitution of larger cations on the compound's slight rhombohedral distortion from cubic symmetry--a property that often degrades the performance of LaAlO[sub 3] substrates for epitaxial high-temperature superconducting films. La[sub 1[minus]x]Sr[sub x]Al[sub 1[minus]x]Ti[sub x]O[sub 3] (x = 0.05, 0.10, 0.15, 0.25), La[sub 1[minus]x]Sr[sub x]Al[sub 1[minus]x]Zr[sub x]O[sub 3], La[sub 1[minus]x]Sr[sub x]Al[sub 1[minus]x]Mg[sub x]O[sub 3[minus]2x]F[sub 2x] and La[sub 1[minus]x]Sr[sub x]Al[sub 1[minus]x]Sc[sub x]O[sub 3[minus]x]F[sub x] (x = 0.05, 0.10, 0.15) were prepared in polycrystalline form and 1--2 mm single crystals of the Sr, Ti- and Sr,Zr-substituted systems were grown using a PbO-PbF[submore » 2]-B[sub 2]O[sub 3]-PbO[sub 2] flux. Shifts in the peak positions of the X-ray powder diffraction patterns confirmed substitution of the larger cations. The diffraction patterns were also typified by line-broadening and a decrease in the rhombohedral splitting at all doping levels. The dielectric constant of LaAlO[sub 3] was unchanged for all of the fluoride-containing systems and for the 5% Sr,Ti- and Sr,Zr-systems.« less