Chemo-mechanical modeling of tumor growth in elastic epithelial tissue

Journal Article · Tue Aug 02 00:00:00 EDT 2016 · AIP Conference Proceedings

DOI:https://doi.org/10.1063/1.4960226· OSTI ID:22608267

Zakharov, Andrey P. ^[1]; Pismen, Len ^[1]

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1. Department of Chemical Engineering, Technion-Israel Institute of Technology, Haifa, 32000 Israel (Israel)

We propose a multiscale chemo-mechanical model of the cancer tumor development in the epithelial tissue. The epithelium is represented by an elastic 2D array of polygonal cells with its own gene regulation dynamics. The model allows the simulation of the evolution of multiple cells interacting via the chemical signaling or mechanically induced strain. The algorithm includes the division and intercalation of cells as well as the transformation of normal cells into a cancerous state triggered by a local failure of the spatial synchronization of the cellular rhythms driven by transcription/translation processes. Both deterministic and stochastic descriptions of the system are given for chemical signaling. The transformation of cells means the modification of their respective parameters responsible for chemo-mechanical interactions. The simulations reproduce a distinct behavior of invasive and localized carcinoma. Generally, the model is designed in such a way that it can be readily modified to take account of any newly understood gene regulation processes and feedback mechanisms affecting chemo-mechanical properties of cells.

• OSTI ID: 22608267
• Journal Information: AIP Conference Proceedings, Vol. 1760, Issue 1; Conference: PC'16: International conference on physics of cancer: Interdisciplinary problems and clinical applications 2016, Tomsk (Russian Federation), 22-25 Mar 2016; Other Information: (c) 2016 Author(s); Country of input: International Atomic Energy Agency (IAEA); ISSN 0094-243X
• Country of Publication: United States
• Language: English

Related Subjects

71 CLASSICAL AND QUANTUM MECHANICS
GENERAL PHYSICS
75 CONDENSED MATTER PHYSICS
SUPERCONDUCTIVITY AND SUPERFLUIDITY
ALGORITHMS
BIOPHYSICS
CARCINOMAS
CLATHRATES
COMPUTERIZED SIMULATION
EPITHELIUM
EVOLUTION
FAILURES
FEEDBACK
GENE REGULATION
GENES
INTERACTIONS
MECHANICAL PROPERTIES
MODIFICATIONS
STOCHASTIC PROCESSES
STRAINS
SYNCHRONIZATION
TRANSCRIPTION
TRANSFORMATIONS