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Title: Chemo-mechanical modeling of tumor growth in elastic epithelial tissue

Abstract

We propose a multiscale chemo-mechanical model of the cancer tumor development in the epithelial tissue. The epithelium is represented by an elastic 2D array of polygonal cells with its own gene regulation dynamics. The model allows the simulation of the evolution of multiple cells interacting via the chemical signaling or mechanically induced strain. The algorithm includes the division and intercalation of cells as well as the transformation of normal cells into a cancerous state triggered by a local failure of the spatial synchronization of the cellular rhythms driven by transcription/translation processes. Both deterministic and stochastic descriptions of the system are given for chemical signaling. The transformation of cells means the modification of their respective parameters responsible for chemo-mechanical interactions. The simulations reproduce a distinct behavior of invasive and localized carcinoma. Generally, the model is designed in such a way that it can be readily modified to take account of any newly understood gene regulation processes and feedback mechanisms affecting chemo-mechanical properties of cells.

Authors:
 [1];  [2];  [3];  [2]
  1. Department of Applied Physics, Perm National Research Polytechnical University, Perm, 614990 (Russian Federation)
  2. Department of Chemical Engineering, Technion-Israel Institute of Technology, Haifa, 32000 Israel (Israel)
  3. (Russian Federation)
Publication Date:
OSTI Identifier:
22608267
Resource Type:
Journal Article
Resource Relation:
Journal Name: AIP Conference Proceedings; Journal Volume: 1760; Journal Issue: 1; Conference: PC'16: International conference on physics of cancer: Interdisciplinary problems and clinical applications 2016, Tomsk (Russian Federation), 22-25 Mar 2016; Other Information: (c) 2016 Author(s); Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSICS; 75 CONDENSED MATTER PHYSICS, SUPERCONDUCTIVITY AND SUPERFLUIDITY; ALGORITHMS; BIOPHYSICS; CARCINOMAS; CLATHRATES; COMPUTERIZED SIMULATION; EPITHELIUM; EVOLUTION; FAILURES; FEEDBACK; GENE REGULATION; GENES; INTERACTIONS; MECHANICAL PROPERTIES; MODIFICATIONS; STOCHASTIC PROCESSES; STRAINS; SYNCHRONIZATION; TRANSCRIPTION; TRANSFORMATIONS

Citation Formats

Bratsun, Dmitry A., E-mail: bratsun@pspu.ru, Zakharov, Andrey P., Theoretical Physics Department, Perm State Humanitarian Pedagogical University, Perm, 614990, and Pismen, Len. Chemo-mechanical modeling of tumor growth in elastic epithelial tissue. United States: N. p., 2016. Web. doi:10.1063/1.4960226.
Bratsun, Dmitry A., E-mail: bratsun@pspu.ru, Zakharov, Andrey P., Theoretical Physics Department, Perm State Humanitarian Pedagogical University, Perm, 614990, & Pismen, Len. Chemo-mechanical modeling of tumor growth in elastic epithelial tissue. United States. doi:10.1063/1.4960226.
Bratsun, Dmitry A., E-mail: bratsun@pspu.ru, Zakharov, Andrey P., Theoretical Physics Department, Perm State Humanitarian Pedagogical University, Perm, 614990, and Pismen, Len. Tue . "Chemo-mechanical modeling of tumor growth in elastic epithelial tissue". United States. doi:10.1063/1.4960226.
@article{osti_22608267,
title = {Chemo-mechanical modeling of tumor growth in elastic epithelial tissue},
author = {Bratsun, Dmitry A., E-mail: bratsun@pspu.ru and Zakharov, Andrey P. and Theoretical Physics Department, Perm State Humanitarian Pedagogical University, Perm, 614990 and Pismen, Len},
abstractNote = {We propose a multiscale chemo-mechanical model of the cancer tumor development in the epithelial tissue. The epithelium is represented by an elastic 2D array of polygonal cells with its own gene regulation dynamics. The model allows the simulation of the evolution of multiple cells interacting via the chemical signaling or mechanically induced strain. The algorithm includes the division and intercalation of cells as well as the transformation of normal cells into a cancerous state triggered by a local failure of the spatial synchronization of the cellular rhythms driven by transcription/translation processes. Both deterministic and stochastic descriptions of the system are given for chemical signaling. The transformation of cells means the modification of their respective parameters responsible for chemo-mechanical interactions. The simulations reproduce a distinct behavior of invasive and localized carcinoma. Generally, the model is designed in such a way that it can be readily modified to take account of any newly understood gene regulation processes and feedback mechanisms affecting chemo-mechanical properties of cells.},
doi = {10.1063/1.4960226},
journal = {AIP Conference Proceedings},
number = 1,
volume = 1760,
place = {United States},
year = {Tue Aug 02 00:00:00 EDT 2016},
month = {Tue Aug 02 00:00:00 EDT 2016}
}