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Title: Measurement of laser power for photo-triggered drug delivery in vivo

Abstract

Thus far, despite many investigations have been carried out for photo-triggered drug delivery systems, most of them suffer from an intrinsic drawback of without real-time monitoring mechanism. Incident intensity of light is a feasible parameter to monitor the drug release profiles. However, it is difficult to measure the incident laser power irradiated onto the photo-triggered carriers in drug delivery systems during in vivo therapy. We design an online measurement method based on the fluorescence intensity ratio (FIR) technique through upconversion nanoparticles. FIR value varies with temperature of sample due to the thermal effect induced by the incident laser, which validates the laser power measurement. Effects of rare earth doping concentration, as well as experimental conditions including laser spots and wavelengths on the measurement behavior were also investigated.

Authors:
; ; ; ; ; ;  [1];  [2]
  1. Key Lab of In-Fiber Integrated Optics, Ministry Education of China, Harbin Engineering University, Harbin 150001 (China)
  2. (China)
Publication Date:
OSTI Identifier:
22597865
Resource Type:
Journal Article
Journal Name:
Journal of Applied Physics
Additional Journal Information:
Journal Volume: 120; Journal Issue: 2; Other Information: (c) 2016 Author(s); Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0021-8979
Country of Publication:
United States
Language:
English
Subject:
75 CONDENSED MATTER PHYSICS, SUPERCONDUCTIVITY AND SUPERFLUIDITY; 71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSICS; DELIVERY; DRUGS; FLUORESCENCE; IN VIVO; IRRADIATION; LASERS; MONITORING; NANOPARTICLES; RARE EARTHS; REAL TIME SYSTEMS; THERAPY; WAVELENGTHS

Citation Formats

Wang, R., Zhang, X. L., Liu, F., Zhang, Z. L., Chen, Y. J., Zhao, E. M., Liu, L., E-mail: liulu@hrbeu.edu.cn, and School of Science, Harbin Engineering University, Harbin 150001. Measurement of laser power for photo-triggered drug delivery in vivo. United States: N. p., 2016. Web. doi:10.1063/1.4958865.
Wang, R., Zhang, X. L., Liu, F., Zhang, Z. L., Chen, Y. J., Zhao, E. M., Liu, L., E-mail: liulu@hrbeu.edu.cn, & School of Science, Harbin Engineering University, Harbin 150001. Measurement of laser power for photo-triggered drug delivery in vivo. United States. doi:10.1063/1.4958865.
Wang, R., Zhang, X. L., Liu, F., Zhang, Z. L., Chen, Y. J., Zhao, E. M., Liu, L., E-mail: liulu@hrbeu.edu.cn, and School of Science, Harbin Engineering University, Harbin 150001. Thu . "Measurement of laser power for photo-triggered drug delivery in vivo". United States. doi:10.1063/1.4958865.
@article{osti_22597865,
title = {Measurement of laser power for photo-triggered drug delivery in vivo},
author = {Wang, R. and Zhang, X. L. and Liu, F. and Zhang, Z. L. and Chen, Y. J. and Zhao, E. M. and Liu, L., E-mail: liulu@hrbeu.edu.cn and School of Science, Harbin Engineering University, Harbin 150001},
abstractNote = {Thus far, despite many investigations have been carried out for photo-triggered drug delivery systems, most of them suffer from an intrinsic drawback of without real-time monitoring mechanism. Incident intensity of light is a feasible parameter to monitor the drug release profiles. However, it is difficult to measure the incident laser power irradiated onto the photo-triggered carriers in drug delivery systems during in vivo therapy. We design an online measurement method based on the fluorescence intensity ratio (FIR) technique through upconversion nanoparticles. FIR value varies with temperature of sample due to the thermal effect induced by the incident laser, which validates the laser power measurement. Effects of rare earth doping concentration, as well as experimental conditions including laser spots and wavelengths on the measurement behavior were also investigated.},
doi = {10.1063/1.4958865},
journal = {Journal of Applied Physics},
issn = {0021-8979},
number = 2,
volume = 120,
place = {United States},
year = {2016},
month = {7}
}