Hyperthermia with rotating magnetic nanowires inducing heat into tumor by fluid friction
- Institute of Thermal Sciences and Engineering, University of Applied Sciences of Western Switzerland, CH 1401 Yverdon-les-Bains (Switzerland)
- Multi-Scale Robotics Lab, Institute of Robotics and Intelligent Systems, ETH Zurich, CH 8092 Zurich (Switzerland)
- Ecole Polytechnique Fédérale de Lausanne (EPFL), EPFL Fribourg, CH 1701 Fribourg (Switzerland)
A magnetic hyperthermia cancer treatment strategy that does not operate by means of conventional heating mechanisms is presented. The proposed approach consists of injecting a gel with homogeneously distributed magnetic nanowires into a tumor. Upon the application of a low-frequency rotating or circularly polarized magnetic field, nanowires spin around their center of viscous drag due to torque generated by shape anisotropy. As a result of external rotational forcing and fluid friction in the nanoparticle's boundary layer, heating occurs. The nanowire dynamics is theoretically and experimentally investigated, and different feasibility proofs of the principle by physical modeling, which adhere to medical guidelines, are presented. The magnetic nanorotors exhibit rotations and oscillations with quite a steady center of gravity, which proves an immobile behavior and guarantees a time-independent homogeneity of the spatial particle distribution in the tumor. Furthermore, a fluid dynamic and thermodynamic heating model is briefly introduced. This model is a generalization of Penne's model that for this method reveals theoretic heating rates that are sufficiently high, and fits well into medical limits defined by present standards.
- OSTI ID:
- 22597701
- Journal Information:
- Journal of Applied Physics, Vol. 120, Issue 6; Other Information: (c) 2016 Author(s); Country of input: International Atomic Energy Agency (IAEA); ISSN 0021-8979
- Country of Publication:
- United States
- Language:
- English
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