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Title: Angle-resolved diffraction grating biosensor based on porous silicon

Abstract

In this study, an optical biosensor based on a porous silicon composite structure was fabricated using a simple method. This structure consists of a thin, porous silicon surface diffraction grating and a one-dimensional porous silicon photonic crystal. An angle-resolved diffraction efficiency spectrum was obtained by measuring the diffraction efficiency at a range of incident angles. The angle-resolved diffraction efficiency of the 2nd and 3rd orders was studied experimentally and theoretically. The device was sensitive to the change of refractive index in the presence of a biomolecule indicated by the shift of the diffraction efficiency spectrum. The sensitivity of this sensor was investigated through use of an 8 base pair antifreeze protein DNA hybridization. The shifts of the angle-resolved diffraction efficiency spectrum showed a relationship with the change of the refractive index, and the detection limit of the biosensor reached 41.7 nM. This optical device is highly sensitive, inexpensive, and simple to fabricate. Using shifts in diffraction efficiency spectrum to detect biological molecules has not yet been explored, so this study establishes a foundation for future work.

Authors:
;  [1]; ; ; ;  [2]
  1. School of Physical Science and Technology, Xinjiang University, Urumqi 830046 (China)
  2. College of Information Science and Engineering, Xinjiang University, Urumqi 830046 (China)
Publication Date:
OSTI Identifier:
22597014
Resource Type:
Journal Article
Resource Relation:
Journal Name: Journal of Applied Physics; Journal Volume: 119; Journal Issue: 9; Other Information: (c) 2016 AIP Publishing LLC; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSICS; 75 CONDENSED MATTER PHYSICS, SUPERCONDUCTIVITY AND SUPERFLUIDITY; ANTIFREEZE; CRYSTALS; DIFFRACTION; DIFFRACTION GRATINGS; DNA; DNA HYBRIDIZATION; EFFICIENCY; ONE-DIMENSIONAL CALCULATIONS; POROUS MATERIALS; PROTEINS; REFRACTIVE INDEX; SENSITIVITY; SENSORS; SILICON; SPECTRA; SURFACES

Citation Formats

Lv, Changwu, Li, Peng, Jia, Zhenhong, E-mail: jzhh@xju.edu.cn, Liu, Yajun, Mo, Jiaqing, and Lv, Xiaoyi. Angle-resolved diffraction grating biosensor based on porous silicon. United States: N. p., 2016. Web. doi:10.1063/1.4943072.
Lv, Changwu, Li, Peng, Jia, Zhenhong, E-mail: jzhh@xju.edu.cn, Liu, Yajun, Mo, Jiaqing, & Lv, Xiaoyi. Angle-resolved diffraction grating biosensor based on porous silicon. United States. doi:10.1063/1.4943072.
Lv, Changwu, Li, Peng, Jia, Zhenhong, E-mail: jzhh@xju.edu.cn, Liu, Yajun, Mo, Jiaqing, and Lv, Xiaoyi. Mon . "Angle-resolved diffraction grating biosensor based on porous silicon". United States. doi:10.1063/1.4943072.
@article{osti_22597014,
title = {Angle-resolved diffraction grating biosensor based on porous silicon},
author = {Lv, Changwu and Li, Peng and Jia, Zhenhong, E-mail: jzhh@xju.edu.cn and Liu, Yajun and Mo, Jiaqing and Lv, Xiaoyi},
abstractNote = {In this study, an optical biosensor based on a porous silicon composite structure was fabricated using a simple method. This structure consists of a thin, porous silicon surface diffraction grating and a one-dimensional porous silicon photonic crystal. An angle-resolved diffraction efficiency spectrum was obtained by measuring the diffraction efficiency at a range of incident angles. The angle-resolved diffraction efficiency of the 2nd and 3rd orders was studied experimentally and theoretically. The device was sensitive to the change of refractive index in the presence of a biomolecule indicated by the shift of the diffraction efficiency spectrum. The sensitivity of this sensor was investigated through use of an 8 base pair antifreeze protein DNA hybridization. The shifts of the angle-resolved diffraction efficiency spectrum showed a relationship with the change of the refractive index, and the detection limit of the biosensor reached 41.7 nM. This optical device is highly sensitive, inexpensive, and simple to fabricate. Using shifts in diffraction efficiency spectrum to detect biological molecules has not yet been explored, so this study establishes a foundation for future work.},
doi = {10.1063/1.4943072},
journal = {Journal of Applied Physics},
number = 9,
volume = 119,
place = {United States},
year = {Mon Mar 07 00:00:00 EST 2016},
month = {Mon Mar 07 00:00:00 EST 2016}
}