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Title: Application of nitrogen plasma immersion ion implantation to titanium nasal implants with nanonetwork surface structure

Abstract

In nasal reconstruction, the response of cells to titanium (Ti) implants is mainly determined by surface features of the implant. In a pilot study, the authors applied electrochemical anodization to Ti surfaces in an alkaline solution to create a network of nanoscale surface structures. This nanonetwork was intended to enhance the responses of primary human nasal epithelial cell (HNEpC) to the Ti surface. In this study, the authors then treated the anodized, nanonetwork-structured Ti surface using nitrogen plasma immersion ion implantation (NPIII) in order to further improve the HNEpC response to the Ti surface. Subsequently, surface characterization was performed to elucidate morphology, roughness, wettability, and chemistry of specimens. Cytotoxicity, blood, and HNEpC responses were also evaluated. Our results demonstrate that NPIII treatment led to the formation of a noncytotoxic TiN-containing thin film (thickness <100 nm) on the electrochemically anodized Ti surface with a nanonetwork-structure. NPIII treatment was shown to improve blood clotting and the adhesion of platelets to the anodized Ti surface as well as the adhesion and proliferation of hNEpC. This research spreads our understanding of the fact that a TiN-containing thin film, produced using NPIII treatment, could be used to improve blood and HNEpC responses to anodized, nanonetwork-structured Ti surfacesmore » in nasal implant applications.« less

Authors:
;  [1];  [2];  [3];  [4];  [5];  [1];  [6];  [6];  [6];  [6];  [6]
  1. Department of Dentistry, National Yang-Ming University, Taipei 112, Taiwan (China)
  2. State Key Laboratory for Mechanical Behavior of Materials, Xi'an Jiaotong University, Xi'an 710049 (China)
  3. State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050 (China)
  4. Division of Rhinology, Department of Otolaryngology Head and Neck Surgery, Taipei Veterans General Hospital, Taipei 112, Taiwan and School of Medicine, National Yang-Ming University, Taipei 112, Taiwan (China)
  5. Institute of Materials Science and Engineering, National Central University, Taoyuan 320, Taiwan (China)
  6. (China)
Publication Date:
OSTI Identifier:
22592869
Resource Type:
Journal Article
Resource Relation:
Journal Name: Journal of Vacuum Science and Technology. A, Vacuum, Surfaces and Films; Journal Volume: 34; Journal Issue: 4; Other Information: (c) 2016 American Vacuum Society; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; 42 ENGINEERING; ANODIZATION; BLOOD; ELECTROCHEMISTRY; HUMAN POPULATIONS; IMPLANTS; ION IMPLANTATION; MORPHOLOGY; NANOSTRUCTURES; NITROGEN; NOSE; PLASMA; ROUGHNESS; SURFACES; THICKNESS; THIN FILMS; TITANIUM; TITANIUM NITRIDES; WETTABILITY

Citation Formats

Sun, Ying-Sui, Yang, Wei-En, Zhang, Lan, Zhu, Hongqin, Lan, Ming-Ying, Lee, Sheng-Wei, Huang, Her-Hsiung, E-mail: hhhuang@ym.edu.tw, Institute of Oral Biology, National Yang-Ming University, Taipei 112, Taiwan, Graduate Institute of Basic Medical Science, China Medical University, Taichung 404, Taiwan, Department of Medical Research, China Medical University Hospital, Taichung 407, Taiwan, Department of Bioinformatics and Medical Engineering, Asia University, Taichung 413, Taiwan, and Department of Stomatology, Taipei Veterans General Hospital, Taipei 112, Taiwan. Application of nitrogen plasma immersion ion implantation to titanium nasal implants with nanonetwork surface structure. United States: N. p., 2016. Web. doi:10.1116/1.4953409.
Sun, Ying-Sui, Yang, Wei-En, Zhang, Lan, Zhu, Hongqin, Lan, Ming-Ying, Lee, Sheng-Wei, Huang, Her-Hsiung, E-mail: hhhuang@ym.edu.tw, Institute of Oral Biology, National Yang-Ming University, Taipei 112, Taiwan, Graduate Institute of Basic Medical Science, China Medical University, Taichung 404, Taiwan, Department of Medical Research, China Medical University Hospital, Taichung 407, Taiwan, Department of Bioinformatics and Medical Engineering, Asia University, Taichung 413, Taiwan, & Department of Stomatology, Taipei Veterans General Hospital, Taipei 112, Taiwan. Application of nitrogen plasma immersion ion implantation to titanium nasal implants with nanonetwork surface structure. United States. doi:10.1116/1.4953409.
Sun, Ying-Sui, Yang, Wei-En, Zhang, Lan, Zhu, Hongqin, Lan, Ming-Ying, Lee, Sheng-Wei, Huang, Her-Hsiung, E-mail: hhhuang@ym.edu.tw, Institute of Oral Biology, National Yang-Ming University, Taipei 112, Taiwan, Graduate Institute of Basic Medical Science, China Medical University, Taichung 404, Taiwan, Department of Medical Research, China Medical University Hospital, Taichung 407, Taiwan, Department of Bioinformatics and Medical Engineering, Asia University, Taichung 413, Taiwan, and Department of Stomatology, Taipei Veterans General Hospital, Taipei 112, Taiwan. Fri . "Application of nitrogen plasma immersion ion implantation to titanium nasal implants with nanonetwork surface structure". United States. doi:10.1116/1.4953409.
@article{osti_22592869,
title = {Application of nitrogen plasma immersion ion implantation to titanium nasal implants with nanonetwork surface structure},
author = {Sun, Ying-Sui and Yang, Wei-En and Zhang, Lan and Zhu, Hongqin and Lan, Ming-Ying and Lee, Sheng-Wei and Huang, Her-Hsiung, E-mail: hhhuang@ym.edu.tw and Institute of Oral Biology, National Yang-Ming University, Taipei 112, Taiwan and Graduate Institute of Basic Medical Science, China Medical University, Taichung 404, Taiwan and Department of Medical Research, China Medical University Hospital, Taichung 407, Taiwan and Department of Bioinformatics and Medical Engineering, Asia University, Taichung 413, Taiwan and Department of Stomatology, Taipei Veterans General Hospital, Taipei 112, Taiwan},
abstractNote = {In nasal reconstruction, the response of cells to titanium (Ti) implants is mainly determined by surface features of the implant. In a pilot study, the authors applied electrochemical anodization to Ti surfaces in an alkaline solution to create a network of nanoscale surface structures. This nanonetwork was intended to enhance the responses of primary human nasal epithelial cell (HNEpC) to the Ti surface. In this study, the authors then treated the anodized, nanonetwork-structured Ti surface using nitrogen plasma immersion ion implantation (NPIII) in order to further improve the HNEpC response to the Ti surface. Subsequently, surface characterization was performed to elucidate morphology, roughness, wettability, and chemistry of specimens. Cytotoxicity, blood, and HNEpC responses were also evaluated. Our results demonstrate that NPIII treatment led to the formation of a noncytotoxic TiN-containing thin film (thickness <100 nm) on the electrochemically anodized Ti surface with a nanonetwork-structure. NPIII treatment was shown to improve blood clotting and the adhesion of platelets to the anodized Ti surface as well as the adhesion and proliferation of hNEpC. This research spreads our understanding of the fact that a TiN-containing thin film, produced using NPIII treatment, could be used to improve blood and HNEpC responses to anodized, nanonetwork-structured Ti surfaces in nasal implant applications.},
doi = {10.1116/1.4953409},
journal = {Journal of Vacuum Science and Technology. A, Vacuum, Surfaces and Films},
number = 4,
volume = 34,
place = {United States},
year = {Fri Jul 15 00:00:00 EDT 2016},
month = {Fri Jul 15 00:00:00 EDT 2016}
}