Stimulated Raman spectroscopy and nanoscopy of molecules using near field photon induced forces without resonant electronic enhancement gain

Tamma, Venkata Ananth; Huang, Fei; Nowak, Derek

doi:10.1063/1.4952738

Title: Stimulated Raman spectroscopy and nanoscopy of molecules using near field photon induced forces without resonant electronic enhancement gain

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Abstract

We report on stimulated Raman spectroscopy and nanoscopy of molecules, excited without resonant electronic enhancement gain, and recorded using near field photon induced forces. Photon-induced interaction forces between the sharp metal coated silicon tip of an Atomic Force Microscope (AFM) and a sample resulting from stimulated Raman excitation were detected. We controlled the tip to sample spacing using the higher order flexural eigenmodes of the AFM cantilever, enabling the tip to come very close to the sample. As a result, the detection sensitivity was increased compared with previous work on Raman force microscopy. Raman vibrational spectra of azobenzene thiol and l-phenylalanine were measured and found to agree well with published results. Near-field force detection eliminates the need for far-field optical spectrometer detection. Recorded images show spatial resolution far below the optical diffraction limit. Further optimization and use of ultrafast pulsed lasers could push the detection sensitivity towards the single molecule limit.

Authors:

Tamma, Venkata Ananth ^[1]; Huang, Fei; Nowak, Derek ^[2]

CaSTL Center, Department of Chemistry, University of California, Irvine, California 92697 (United States)
Molecular Vista, Inc., 6840 Via Del Oro, San Jose, California 95119 (United States)

Publication Date:: Mon Jun 06 00:00:00 EDT 2016

OSTI Identifier:: 22590764

Resource Type:: Journal Article

Journal Name:: Applied Physics Letters

Additional Journal Information:: Journal Volume: 108; Journal Issue: 23; Other Information: (c) 2016 Author(s); Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0003-6951

Country of Publication:: United States

Language:: English

Subject:: 71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSICS; ATOMIC FORCE MICROSCOPY; DETECTION; DIFFRACTION; GAIN; LASERS; METALS; MOLECULES; OPTICAL SPECTROMETERS; OPTIMIZATION; PHENYLALANINE; PHOTONS; RAMAN SPECTROSCOPY; SENSITIVITY; SPATIAL RESOLUTION

Citation Formats


                    Tamma, Venkata Ananth, Huang, Fei, Kumar Wickramasinghe, H., E-mail: hkwick@uci.edu, and Nowak, Derek. Stimulated Raman spectroscopy and nanoscopy of molecules using near field photon induced forces without resonant electronic enhancement gain.  United States: N. p., 2016. 
        Web.  doi:10.1063/1.4952738.

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                    Tamma, Venkata Ananth, Huang, Fei, Kumar Wickramasinghe, H., E-mail: hkwick@uci.edu, & Nowak, Derek. Stimulated Raman spectroscopy and nanoscopy of molecules using near field photon induced forces without resonant electronic enhancement gain.  United States.  https://doi.org/10.1063/1.4952738

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                    Tamma, Venkata Ananth, Huang, Fei, Kumar Wickramasinghe, H., E-mail: hkwick@uci.edu, and Nowak, Derek. 2016.  
        "Stimulated Raman spectroscopy and nanoscopy of molecules using near field photon induced forces without resonant electronic enhancement gain".  United States.  https://doi.org/10.1063/1.4952738.

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@article{osti_22590764,

  title        = {Stimulated Raman spectroscopy and nanoscopy of molecules using near field photon induced forces without resonant electronic enhancement gain},

  author       = {Tamma, Venkata Ananth and Huang, Fei and Kumar Wickramasinghe, H., E-mail: hkwick@uci.edu and Nowak, Derek},

  abstractNote = {We report on stimulated Raman spectroscopy and nanoscopy of molecules, excited without resonant electronic enhancement gain, and recorded using near field photon induced forces. Photon-induced interaction forces between the sharp metal coated silicon tip of an Atomic Force Microscope (AFM) and a sample resulting from stimulated Raman excitation were detected. We controlled the tip to sample spacing using the higher order flexural eigenmodes of the AFM cantilever, enabling the tip to come very close to the sample. As a result, the detection sensitivity was increased compared with previous work on Raman force microscopy. Raman vibrational spectra of azobenzene thiol and l-phenylalanine were measured and found to agree well with published results. Near-field force detection eliminates the need for far-field optical spectrometer detection. Recorded images show spatial resolution far below the optical diffraction limit. Further optimization and use of ultrafast pulsed lasers could push the detection sensitivity towards the single molecule limit.},

  doi          = {10.1063/1.4952738},

  url          = {https://www.osti.gov/biblio/22590764},
  journal      = {Applied Physics Letters},

  issn         = {0003-6951},

  number       = 23,

  volume       = 108,

  place        = {United States},

  year         = {Mon Jun 06 00:00:00 EDT 2016},

  month        = {Mon Jun 06 00:00:00 EDT 2016}

}

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