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Title: Multiple stimulated emission fluorescence photoacoustic sensing and spectroscopy

Abstract

Multiple stimulated emission fluorescence photoacoustic (MSEF-PA) phenomenon is demonstrated in this letter. Under simultaneous illumination of pumping light and stimulated emission light, the fluorescence emission process is speeded up by the stimulated emission effect. This leads to nonlinear enhancement of photoacoustic signal while the quantity of absorbed photons is more than that of fluorescent molecules illuminated by pumping light. The electronic states' specificity of fluorescent molecular can also be labelled by the MSEF-PA signals, which can potentially be used to obtain fluorescence excitation spectrum in deep scattering tissue with nonlinearly enhanced photoacoustic detection. In this preliminary study, the fluorescence excitation spectrum is reconstructed by MSEF-PA signals through sweeping the wavelength of exciting light, which confirms the theoretical derivation well.

Authors:
 [1];  [2]; ; ;  [1];  [3]
  1. School of Electrical and Electronic Engineering, Nanyang Technological University, Singapore 639798 (Singapore)
  2. (China)
  3. Key Laboratory of OptoElectronic Science and Technology for Medicine, Ministry of Education, Fujian Normal University, Fuzhou 350007 (China)
Publication Date:
OSTI Identifier:
22590637
Resource Type:
Journal Article
Resource Relation:
Journal Name: Applied Physics Letters; Journal Volume: 109; Journal Issue: 1; Other Information: (c) 2016 Author(s); Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSICS; EXCITATION; FLUORESCENCE; MOLECULES; NONLINEAR PROBLEMS; PHOTONS; PUMPING; SCATTERING; SIGNALS; SPECTROSCOPY; STIMULATED EMISSION; VISIBLE RADIATION; WAVELENGTHS

Citation Formats

Li, Gaoming, Key Laboratory of OptoElectronic Science and Technology for Medicine, Ministry of Education, Fujian Normal University, Fuzhou 350007, Gao, Fei, Feng, Xiaohua, Zheng, Yuanjin, E-mail: yjzheng@ntu.edu.sg, and Qiu, Yishen. Multiple stimulated emission fluorescence photoacoustic sensing and spectroscopy. United States: N. p., 2016. Web. doi:10.1063/1.4955096.
Li, Gaoming, Key Laboratory of OptoElectronic Science and Technology for Medicine, Ministry of Education, Fujian Normal University, Fuzhou 350007, Gao, Fei, Feng, Xiaohua, Zheng, Yuanjin, E-mail: yjzheng@ntu.edu.sg, & Qiu, Yishen. Multiple stimulated emission fluorescence photoacoustic sensing and spectroscopy. United States. doi:10.1063/1.4955096.
Li, Gaoming, Key Laboratory of OptoElectronic Science and Technology for Medicine, Ministry of Education, Fujian Normal University, Fuzhou 350007, Gao, Fei, Feng, Xiaohua, Zheng, Yuanjin, E-mail: yjzheng@ntu.edu.sg, and Qiu, Yishen. Mon . "Multiple stimulated emission fluorescence photoacoustic sensing and spectroscopy". United States. doi:10.1063/1.4955096.
@article{osti_22590637,
title = {Multiple stimulated emission fluorescence photoacoustic sensing and spectroscopy},
author = {Li, Gaoming and Key Laboratory of OptoElectronic Science and Technology for Medicine, Ministry of Education, Fujian Normal University, Fuzhou 350007 and Gao, Fei and Feng, Xiaohua and Zheng, Yuanjin, E-mail: yjzheng@ntu.edu.sg and Qiu, Yishen},
abstractNote = {Multiple stimulated emission fluorescence photoacoustic (MSEF-PA) phenomenon is demonstrated in this letter. Under simultaneous illumination of pumping light and stimulated emission light, the fluorescence emission process is speeded up by the stimulated emission effect. This leads to nonlinear enhancement of photoacoustic signal while the quantity of absorbed photons is more than that of fluorescent molecules illuminated by pumping light. The electronic states' specificity of fluorescent molecular can also be labelled by the MSEF-PA signals, which can potentially be used to obtain fluorescence excitation spectrum in deep scattering tissue with nonlinearly enhanced photoacoustic detection. In this preliminary study, the fluorescence excitation spectrum is reconstructed by MSEF-PA signals through sweeping the wavelength of exciting light, which confirms the theoretical derivation well.},
doi = {10.1063/1.4955096},
journal = {Applied Physics Letters},
number = 1,
volume = 109,
place = {United States},
year = {Mon Jul 04 00:00:00 EDT 2016},
month = {Mon Jul 04 00:00:00 EDT 2016}
}