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Title: Ion therapy for uveal melanoma in new human eye phantom based on GEANT4 toolkit

Abstract

Radiotherapy with ion beams like proton and carbon has been used for treatment of eye uveal melanoma for many years. In this research, we have developed a new phantom of human eye for Monte Carlo simulation of tumors treatment to use in GEANT4 toolkit. Total depth−dose profiles for the proton, alpha, and carbon incident beams with the same ranges have been calculated in the phantom. Moreover, the deposited energy of the secondary particles for each of the primary beams is calculated. The dose curves are compared for 47.8 MeV proton, 190.1 MeV alpha, and 1060 MeV carbon ions that have the same range in the target region reaching to the center of tumor. The passively scattered spread-out Bragg peak (SOBP) for each incident beam as well as the flux curves of the secondary particles including neutron, gamma, and positron has been calculated and compared for the primary beams. The high sharpness of carbon beam's Bragg peak with low lateral broadening is the benefit of this beam in hadrontherapy but it has disadvantages of dose leakage in the tail after its Bragg peak and high intensity of neutron production. However, proton beam, which has a good conformation with tumor shape owingmore » to the beam broadening caused by scattering, can be a good choice for the large-size tumors.« less

Authors:
 [1];  [1];  [2]
  1. Physics Department, Hakim Sabzevari University, Sabzevar (Iran, Islamic Republic of)
  2. (Italy)
Publication Date:
OSTI Identifier:
22577871
Resource Type:
Journal Article
Resource Relation:
Journal Name: Medical Dosimetry; Journal Volume: 41; Journal Issue: 2; Other Information: Copyright (c) 2016 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
61 RADIATION PROTECTION AND DOSIMETRY; 62 RADIOLOGY AND NUCLEAR MEDICINE; BRAGG CURVE; CARBON IONS; COMPUTERIZED SIMULATION; ION BEAMS; MELANOMAS; MONTE CARLO METHOD; PHANTOMS; PROTON BEAMS; RADIOTHERAPY

Citation Formats

Mahdipour, Seyed Ali, Mowlavi, Ali Asghar, E-mail: amowlavi@hsu.ac.ir, and ICTP, Associate Federation Scheme, Medical Physics Field, Trieste. Ion therapy for uveal melanoma in new human eye phantom based on GEANT4 toolkit. United States: N. p., 2016. Web. doi:10.1016/J.MEDDOS.2015.10.005.
Mahdipour, Seyed Ali, Mowlavi, Ali Asghar, E-mail: amowlavi@hsu.ac.ir, & ICTP, Associate Federation Scheme, Medical Physics Field, Trieste. Ion therapy for uveal melanoma in new human eye phantom based on GEANT4 toolkit. United States. doi:10.1016/J.MEDDOS.2015.10.005.
Mahdipour, Seyed Ali, Mowlavi, Ali Asghar, E-mail: amowlavi@hsu.ac.ir, and ICTP, Associate Federation Scheme, Medical Physics Field, Trieste. Fri . "Ion therapy for uveal melanoma in new human eye phantom based on GEANT4 toolkit". United States. doi:10.1016/J.MEDDOS.2015.10.005.
@article{osti_22577871,
title = {Ion therapy for uveal melanoma in new human eye phantom based on GEANT4 toolkit},
author = {Mahdipour, Seyed Ali and Mowlavi, Ali Asghar, E-mail: amowlavi@hsu.ac.ir and ICTP, Associate Federation Scheme, Medical Physics Field, Trieste},
abstractNote = {Radiotherapy with ion beams like proton and carbon has been used for treatment of eye uveal melanoma for many years. In this research, we have developed a new phantom of human eye for Monte Carlo simulation of tumors treatment to use in GEANT4 toolkit. Total depth−dose profiles for the proton, alpha, and carbon incident beams with the same ranges have been calculated in the phantom. Moreover, the deposited energy of the secondary particles for each of the primary beams is calculated. The dose curves are compared for 47.8 MeV proton, 190.1 MeV alpha, and 1060 MeV carbon ions that have the same range in the target region reaching to the center of tumor. The passively scattered spread-out Bragg peak (SOBP) for each incident beam as well as the flux curves of the secondary particles including neutron, gamma, and positron has been calculated and compared for the primary beams. The high sharpness of carbon beam's Bragg peak with low lateral broadening is the benefit of this beam in hadrontherapy but it has disadvantages of dose leakage in the tail after its Bragg peak and high intensity of neutron production. However, proton beam, which has a good conformation with tumor shape owing to the beam broadening caused by scattering, can be a good choice for the large-size tumors.},
doi = {10.1016/J.MEDDOS.2015.10.005},
journal = {Medical Dosimetry},
number = 2,
volume = 41,
place = {United States},
year = {Fri Jul 01 00:00:00 EDT 2016},
month = {Fri Jul 01 00:00:00 EDT 2016}
}