WE-D-303-05: Dosimetric Accuracy of CBCT Images Estimated by a Motion Modeling and Free-Form Deformation Technique for Radiotherapy of Lung Cancer
- Duke University Medical Center, Durham, NC (United States)
Purpose: To investigate the dosimetric accuracy of CBCTs estimated by a motion modeling and free-form deformation(MM-FD) technique for radiotherapy of lung cancer. Methods: Various inter-fractional variations featuring patient motion pattern change, tumor size change and tumor average position change were simulated from planning-CT to on-board images using both digital and physical motion phantoms. The doses calculated on the planning-CT (planned doses), the on-board CBCT estimated by MM-FD (MM-FD doses) and the on-board CBCT reconstructed by the conventional Feldkamp-Davis-Kress(FDK) algorithm (FDK doses) were compared to the on-board dose calculated on the ‘gold-standard’ on-board images (gold-standard doses). The absolute deviations of minimum dose (dDmin), maximum dose (dDmax), mean dose (dDmean) and dose coverage (dV100%) of PTV were evaluated. In addition, 4D on-board dose accumulations were performed using the 4D-CBCT images estimated by MM-FD. The accumulated doses were compared to measurements using OSL detectors and radiochromic films. Results: Of all the 50 scenarios simulated, the average(± standard deviation) dDmin, dDmax, dDmean and dV100% (values normalized by the prescription dose or the PTV volume) between the planned and the gold-standard PTV doses were 34.8% (± 29.2%), 3.2% (± 3.8%), 3.5% (± 3.5%) and 13.0% (± 11.4%), respectively. The corresponding values of FDK PTV doses were 3.1% (± 3.7%), 1.4% (± 1.1%), 2.1% (± 0.8%) and 14.5% (± 14.2%), respectively. In contrast, the corresponding values of MM-FD PTV doses were 0.4% (± 0.5%), 0.9% (± 0.7%), 0.6% (± 0.4%) and 0.9% (± 0.8%), respectively.For the 4D dose accumulation study, the average(± standard deviation) absolute dose deviation (normalized by local doses) between the accumulated doses and the OSL measured doses was 3.0% (± 2.4%). The average gamma pass-rate(3%/3mm) between the accumulated doses and the radiochromic film measured doses was 96.1%. Conclusion: MM-FD estimated CBCT enables accurate on-board dose calculation and accumulation for lung radiation therapy. The research was funded by the National Institutes of Health Grant No. R01-CA184173 and a grant from Varian Medical Systems.
- OSTI ID:
- 22570164
- Journal Information:
- Medical Physics, Vol. 42, Issue 6; Other Information: (c) 2015 American Association of Physicists in Medicine; Country of input: International Atomic Energy Agency (IAEA); ISSN 0094-2405
- Country of Publication:
- United States
- Language:
- English
Similar Records
SU-G-JeP3-04: Estimating 4D CBCT from Prior Information and Extremely Limited Angle Projections Using Structural PCA and Weighted Free-Form Deformation
SU-D-17A-01: Geometric and Dosimetric Evaluation of a 4D-CBCT Reconstruction Technique Using Prior Knowledge