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Title: SU-E-T-57: A Novel Method to Improve Dose Heterogeneity of Target and Organs at Risk Sparing in the Intensity-Modulated Radiotherapy for Stage III Lung Cancer

Abstract

Purpose: Intensity-modulated radiotherapy (IMRT) treatment for lung cancer is difficult due to the heterogeneous dose distribution and excessive dose to the organs at risk (OARs). We introduce a simple method based on the base dose function (BDF) in Eclipse treatment planning system to overcome the difficulties. Methods: Thirteen patients suffered from stage III non-small cell lung cancer (NSCLC) were enrolled in the study. Three kinds of approaches were applied to obtain clinically acceptable treatment plans: 1) conventionally optimizing method with hot and cold spots re-optimization (CO); 2) target-divided optimizing method (TDO) in which the optimization objective in the lung density of planning target volume (PTV) was set to 2 to 4 Gy higher than in the soft tissue density; 3) base dose function (BDF) in which the treatment plan was produced based on the original plan for re-optimization. CO, TDO and BDF methods were then compared in terms of conformity index (CI), homogeneity index (HI), OARs sparing and monitor units (MUs). Additionally, delta4, portal dosimetry and IMSure were used to measure the dose delivering accuracy. Results: The BDF technique provided more superior CI and HI than the other two methods. Moreover, the new method also reduced the lung, esophagus, heartmore » and spinal cord dose. However, the BDF plans needed extra 15% and 10% MUs than the CO and TDO methods. Dose verification results demonstrated good and comparable γ pass rates among the three methods. Conclusion: The proposed BDF method greatly improves the dose homogeneity and OARs sparing in the IMRT treatment for lung cancer.« less

Authors:
;  [1]
  1. Cancer Hospital of Shantou University Medical College, Shantou (China)
Publication Date:
OSTI Identifier:
22545187
Resource Type:
Journal Article
Resource Relation:
Journal Name: Medical Physics; Journal Volume: 42; Journal Issue: 6; Other Information: (c) 2015 American Association of Physicists in Medicine; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; ACCURACY; DOSIMETRY; ESOPHAGUS; HAZARDS; HEART; LUNGS; NEOPLASMS; OPTIMIZATION; PLANNING; RADIATION DOSE DISTRIBUTIONS; RADIATION DOSES; RADIOTHERAPY; SPINAL CORD

Citation Formats

Huang, B-T, and Lu, J-Y. SU-E-T-57: A Novel Method to Improve Dose Heterogeneity of Target and Organs at Risk Sparing in the Intensity-Modulated Radiotherapy for Stage III Lung Cancer. United States: N. p., 2015. Web. doi:10.1118/1.4924418.
Huang, B-T, & Lu, J-Y. SU-E-T-57: A Novel Method to Improve Dose Heterogeneity of Target and Organs at Risk Sparing in the Intensity-Modulated Radiotherapy for Stage III Lung Cancer. United States. doi:10.1118/1.4924418.
Huang, B-T, and Lu, J-Y. Mon . "SU-E-T-57: A Novel Method to Improve Dose Heterogeneity of Target and Organs at Risk Sparing in the Intensity-Modulated Radiotherapy for Stage III Lung Cancer". United States. doi:10.1118/1.4924418.
@article{osti_22545187,
title = {SU-E-T-57: A Novel Method to Improve Dose Heterogeneity of Target and Organs at Risk Sparing in the Intensity-Modulated Radiotherapy for Stage III Lung Cancer},
author = {Huang, B-T and Lu, J-Y},
abstractNote = {Purpose: Intensity-modulated radiotherapy (IMRT) treatment for lung cancer is difficult due to the heterogeneous dose distribution and excessive dose to the organs at risk (OARs). We introduce a simple method based on the base dose function (BDF) in Eclipse treatment planning system to overcome the difficulties. Methods: Thirteen patients suffered from stage III non-small cell lung cancer (NSCLC) were enrolled in the study. Three kinds of approaches were applied to obtain clinically acceptable treatment plans: 1) conventionally optimizing method with hot and cold spots re-optimization (CO); 2) target-divided optimizing method (TDO) in which the optimization objective in the lung density of planning target volume (PTV) was set to 2 to 4 Gy higher than in the soft tissue density; 3) base dose function (BDF) in which the treatment plan was produced based on the original plan for re-optimization. CO, TDO and BDF methods were then compared in terms of conformity index (CI), homogeneity index (HI), OARs sparing and monitor units (MUs). Additionally, delta4, portal dosimetry and IMSure were used to measure the dose delivering accuracy. Results: The BDF technique provided more superior CI and HI than the other two methods. Moreover, the new method also reduced the lung, esophagus, heart and spinal cord dose. However, the BDF plans needed extra 15% and 10% MUs than the CO and TDO methods. Dose verification results demonstrated good and comparable γ pass rates among the three methods. Conclusion: The proposed BDF method greatly improves the dose homogeneity and OARs sparing in the IMRT treatment for lung cancer.},
doi = {10.1118/1.4924418},
journal = {Medical Physics},
number = 6,
volume = 42,
place = {United States},
year = {Mon Jun 15 00:00:00 EDT 2015},
month = {Mon Jun 15 00:00:00 EDT 2015}
}